{"id":15117,"date":"2017-10-11T10:42:02","date_gmt":"2017-10-11T17:42:02","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=15117"},"modified":"2024-01-30T15:27:59","modified_gmt":"2024-01-30T23:27:59","slug":"can-hear-now-ensuring-good-cellular-connections-brain","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/can-hear-now-ensuring-good-cellular-connections-brain\/","title":{"rendered":"Can you hear me now? Ensuring good cellular connections in the brain"},"content":{"rendered":"<p>LA JOLLA\u2014To have a good phone conversation, you need a good cellular connection. What's true for mobile phones also turns out to be true for neurons.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-eO-93_ThrQ4\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/eO-93_ThrQ4?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>Salk Institute scientists have discovered that brain cells called astrocytes initiate communication between pairs of neurons early in development by inducing specific changes in both members of the pair. The work, published in <a href=\"http:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(17)30922-4\"><em>Neuron<\/em><\/a> on October 11, 2017, has important implications for <a href=\"https:\/\/www.salk.edu\/de\/science\/research\/neuroscience-and-neurological-disorders\/\">neurodevelopmental disorders<\/a> such as autism, ADHD and schizophrenia that are thought to result at least partly from faulty communication between neurons.<\/p>\n<p>\"When the brain is forming, all the neurons have to make the right connections with each other to function properly,\" says <a href=\"https:\/\/www.salk.edu\/de\/scientist\/nicola-allen\/\">Nicola Allen<\/a>, an assistant professor in Salk's Molecular Neurobiology Laboratory and senior author of the paper. \"But how that happens, and what the molecular signals are in the process, is still something we don\u2019t fully understand.\"<\/p>\n<p>Although neurons are the most well known cells in the brain, they make up just half the total number of cells. The other half includes various types of cells, the most abundant of which are astrocytes. In recent years, scientists have learned that astrocytes are necessary for neurons to form active connections with each other across tiny gaps called synapses. But the exact mechanism behind the process has been a mystery\u2014until now.<\/p>\n<figure id=\"attachment_15120\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"244\" height=\"322\" class=\"wp-image-15120 size-full\" title=\"img-responsive\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Fluorescently-labeled-astrocytes.jpg\" alt=\"Fluorescently labeled astrocytes (large green structures) and neuronal postsynaptic receptors (red).\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Fluorescently-labeled-astrocytes.jpg 244w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Fluorescently-labeled-astrocytes-227x300.jpg 227w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Fluorescently-labeled-astrocytes-147x194.jpg 147w\" sizes=\"auto, (max-width: 244px) 100vw, 244px\" \/><figcaption class=\"wp-caption-text\">Fluorescently labeled astrocytes (large green structures) and neuronal postsynaptic receptors (red).<\/p>\n<p> Kredit: Salk Institut<\/figcaption><\/figure>\n<p>Over the years, various labs identified different proteins that astrocytes secrete which seem to influence neuronal development. But none of the proteins they discovered resulted in functional synapses that promote active communication between neurons. The synapses were essentially silent.<\/p>\n<p>Then, as a postdoctoral researcher, Allen discovered that a protein secreted by astrocytes called glypican 4 somehow induced communication between nearby neurons. With glypican 4 present, neurons sending information (termed \"presynaptic\") were partnering effectively with neurons receiving it (\"postsynaptic\"). The neurons exchange messages in the form of chemicals that travel across the gap, and are received by molecular docking stations on the receiving end, known as \u201creceptors.\u201d What Allen didn't know was how. Once she established her own lab at Salk, she set out to uncover the details.<\/p>\n<p>Isabella Farhy-Tselnicker, a Salk research associate and the paper's first author, adds, \"Following up on Nicola's work on glypican 4, I wanted to figure out what happens in the neurons and the synapse to make the synaptic connection. What are the processes? Who are the cells talking to?\"<\/p>\n<p>Allen and Farhy-Tselnicker began by treating cultures of neurons with either glypican 4 or another astrocyte-secreted protein called thrombospondin, which induces changes in neurons but doesn't result in any synaptic communication. The idea was to compare the two sets of cultures and see what was different in the ones treated with glypican 4 that made those neurons able to communicate.<\/p>\n<figure id=\"attachment_15121\"  class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"200\" class=\"img-responsive wp-image-15121 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Nicola-Allen_Isabella-FarhyY49A0630-1-300x200.jpg\" alt=\"Nicola Allen and Isabella Farhy-Tselnicker\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Nicola-Allen_Isabella-FarhyY49A0630-1-300x200.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Nicola-Allen_Isabella-FarhyY49A0630-1-768x512.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Nicola-Allen_Isabella-FarhyY49A0630-1-1024x683.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Nicola-Allen_Isabella-FarhyY49A0630-1-147x98.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Nicola-Allen_Isabella-FarhyY49A0630-1-458x305.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Nicola-Allen_Isabella-FarhyY49A0630-1-585x390.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Nicola-Allen_Isabella-FarhyY49A0630-1-553x369.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Nicola-Allen_Isabella-FarhyY49A0630-1-750x500.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Nicola-Allen_Isabella-FarhyY49A0630-1-945x630.jpg 945w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-caption-text\">From left: Nicola Allen and Isabella Farhy-Tselnicker<\/p>\n<p> <a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Nicola-Allen_Isabella-FarhyY49A0630-1.jpg\">Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.<\/p>\n<p> Kredit: Salk Institut<\/figcaption><\/figure>\n<p>The duo found that 49 genes were activated in response to treatment with glypican 4, but only 3 were activated in response to thrombospondin. The fact that there was no overlap between the genes suggested that the two proteins are involved in very different cellular systems, and that glypican 4 is critical to making synapses active.<\/p>\n<p>Further experiments revealed that glypican 4 increases the numbers of specific kinds of receptors on the receiving neurons (postsynaptic). Glypican 4 recruits the receptors to the cell surface by inducing the release of a \u00ad\u00ad\u00ad\u00ad\u00ad\u00ad\u00adprotein called neuronal pentraxin 1 (NP1) that directly binds to the receptors. Without NP1 binding to the receptors, Allen and Farhy-Tselnicker found, synapses remained silent. Thus, glypican 4 is needed to make postsynaptic neurons receptive to input, the researchers say.<\/p>\n<p>Other studies have found that NP1 is released by the neurons sending information. So the Salk team also looked into what might be happening on the presynaptic side of the connection. They found that the presynaptic neurons released NP1 specifically in response to glypican 4, meaning that a single protein released by astrocytes is responsible for enabling meaningful connections by acting on both sending and receiving neurons.<\/p>\n<p>\"We did not expect to find that a protein secreted by astrocytes would impact neurons on both sides of the synapse,\" adds Allen, who holds the Hearst Foundation Development Chair. \"Not only does this reveal a more complex role for astrocytes as organizers of active synaptic connections, it also offers an exciting therapeutic target for synaptic dysfunction.<\/p>\n<p>The lab's future work will explore ways of targeting astrocytes to come up with novel therapies for neurological disorders.<\/p>\n<p>Other authors included Adriana C. M. van Casteren of Salk, Aletheia Lee of the University of Oxford, Veronica T. Chang of the MRC Laboratory of Molecular Biology, and A. Radu Aricescu of the University of Oxford and the MRC Laboratory of Molecular Biology.<\/p>\n<p>The work was funded by the National Institutes of Health\u2013National Institutes of Neurological Disorders and Stroke; the Hearst, Pew, Ellison, Dana, and Whitehall Foundations; Larry and Carol Greenfield; the Catarina Foundation; the Wellcome Trust; the UK Medical Research Council; and the Wellcome Trust Centre for Human Genetics.<\/p>","protected":false},"featured_media":15119,"template":"","faculty":[81],"disease-research":[459,124],"class_list":["post-15117","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-nicola-allen","disease-research-glial-biology","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Can you hear me now? Ensuring good cellular connections in the brain - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/can-hear-now-ensuring-good-cellular-connections-brain\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can you hear me now? Ensuring good cellular connections in the brain - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014To have a good phone conversation, you need a good cellular connection. 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