{"id":12210,"date":"2017-01-26T00:00:30","date_gmt":"2017-01-26T08:00:30","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=12210"},"modified":"2024-01-30T15:31:44","modified_gmt":"2024-01-30T23:31:44","slug":"feed-cold-starve-fever-not-fast-according-salk-research","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/","title":{"rendered":"Feed a cold, starve a fever? Not so fast, according to Salk research"},"content":{"rendered":"<p>LA JOLLA\u2014The last time you had a stomach bug, you probably didn\u2019t feel much like eating. This loss of appetite is part of your body\u2019s normal response to an illness but is not well understood. Sometimes eating less during illness promotes a faster recovery, but other times\u2014such as when cancer patients experience wasting\u2014the loss of appetite can be deadly.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-10 col-md-push-1\"><div class=\"video-anchor\" id=\"video-PjDVB7COQu4\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/PjDVB7COQu4?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>Now, research from the Salk Institute shows how bacteria block the appetite loss response in their host to both make the host healthier and also promote the bacteria\u2019s transmission to other hosts. This surprising discovery, published in the journal <a href=\"http:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(17)30054-5\" target=\"_blank\" rel=\"noopener\"><em>Zelle<\/em><\/a> on January 26, 2017, reveals a link between appetite and infection and could have implications in treating infectious diseases, infection transmission and appetite loss associated with illness, aging, inflammation or medical interventions (like chemotherapy).<\/p>\n<p>\u201cIt\u2019s long been known that infections cause loss of appetite but the function of that, if any, is only beginning to be understood,\u201d says <a href=\"https:\/\/www.salk.edu\/de\/scientist\/janelle-ayres\/\" target=\"_blank\" rel=\"noopener\">Janelle Ayres<\/a>, assistant professor at Salk Institute\u2019s <a href=\"https:\/\/www.salk.edu\/de\/science\/research-centers\/nomis-center\/\">Nomis Foundation Laboratorien f\u00fcr Immunbiologie und mikrobielle Pathogenese<\/a>.<\/p>\n<figure id=\"attachment_12232\"  class=\"wp-caption alignright\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"458\" class=\"wp-image-12232 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-458x458.jpg\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-768x768.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-1024x1024.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-767x767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-945x945.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium.jpg 2048w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/a><figcaption class=\"wp-caption-text\">A Salk Institute study shows how <em>Salmonellen<\/em> blocks the appetite loss response in hosts to both make the host healthier and promote the bacteria\u2019s survival and transmission. <\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium.jpg\" target=\"_blank\" rel=\"noopener\">Klicken Sie hier<\/a> for a high-resolution image <\/p>\n<p>Kredit: Salk Institut<\/figcaption><\/figure>\n<p>Mice orally infected with the bacteria <em>Salmonellen<\/em> Typhimurium typically experience appetite loss and eventually become much sicker as the bacteria become more virulent\u2014spreading from the intestines to other tissues in the body. Ayres\u2019 team tested different conditions in the infected mice and found that sick mice that consumed extra calories despite their appetite loss actually survived longer. It turns out this survival wasn\u2019t due to a more active immune response by well-fed animals (as measured by levels of the bacteria in the host). Instead, it was because the <em>Salmonellen<\/em> weren\u2019t spreading outside of the intestines and throughout the body when the mice ate more, which enabled the animals to stay healthy despite infection. Even more surprising, the <em>Salmonellen<\/em> were acting on the intestine to try to suppress the appetite loss in the host.<\/p>\n<p>The finding was initially puzzling: why would the bacteria become less virulent and not spread to other areas in the body when nutrients were more plentiful? And why would <em>Salmonellen<\/em> actively promote this condition? It turns out the bacteria were making a tradeoff between virulence, which is the ability of a microbe to cause disease within one host, and transmission, which is its ability to spread and establish infections between multiple hosts.<\/p>\n<p>\u201cWhat we found was that appetite loss makes the <em>Salmonellen<\/em> more virulent, perhaps because it needs to go beyond the intestines to find nutrients for itself. This increased virulence kills its host too fast, which compromises the bacteria\u2019s ability to spread to new hosts,\u201d explains Sheila Rao, a Salk research associate and the first author on the study. \u201cThe tradeoff between transmission and virulence has not been appreciated before\u2014it was previously thought that virulence and transmission were coupled.\u201d<\/p>\n<p>When the host ate more and survived longer during infection, the <em>Salmonellen<\/em> benefitted: bacteria in those mice were able to spread via feces to other animals and increase its transmission between hosts, as compared to bacteria in mice who didn\u2019t eat and died sooner due to heightened bacterial virulence.<\/p>\n<figure id=\"attachment_12217\"  class=\"wp-caption alignleft\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Janelle-Ayres-and-Sheila-Rao_IMG_7720.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"305\" class=\"img-responsive wp-image-12217 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Janelle-Ayres-and-Sheila-Rao_IMG_7720-458x305.jpg\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Janelle-Ayres-and-Sheila-Rao_IMG_7720-458x305.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Janelle-Ayres-and-Sheila-Rao_IMG_7720-300x200.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Janelle-Ayres-and-Sheila-Rao_IMG_7720-768x512.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Janelle-Ayres-and-Sheila-Rao_IMG_7720-1024x683.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Janelle-Ayres-and-Sheila-Rao_IMG_7720-147x98.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Janelle-Ayres-and-Sheila-Rao_IMG_7720-585x390.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Janelle-Ayres-and-Sheila-Rao_IMG_7720-553x369.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Janelle-Ayres-and-Sheila-Rao_IMG_7720-750x500.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Janelle-Ayres-and-Sheila-Rao_IMG_7720-945x630.jpg 945w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/a><figcaption class=\"wp-caption-text\">From left: Janelle Ayres and Sheila Rao <\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Janelle-Ayres-and-Sheila-Rao_IMG_7720.jpg\" target=\"_blank\" rel=\"noopener\">Klicken Sie hier<\/a> for a high-resolution image <\/p>\n<p>Kredit: Salk Institut<\/figcaption><\/figure>\n<p>The researchers discovered that, to halt the appetite-loss response and boost transmission between hosts, <em>Salmonellen<\/em> produces a molecule called SlrP, which blocks activation of an immune protein (cytokine) in the intestines. This cytokine typically communicates with the brain\u2019s appetite center, called the hypothalamus, to prompt the host to lose its appetite during infection. The team found that mice infected with <em>Salmonellen<\/em> that couldn\u2019t make SlrP ate less food while infected, lost more weight and died faster than control mice.<\/p>\n<p>Though the same gut-brain pathway tied to appetite loss exists in the human as in mice, Ayres cautions that infection responses are dependent on many factors and that whether eating\u2014or fasting\u2014during illness can improve one\u2019s health will depend in large part on what the causative agent of the infection is. Her team is planning to search the human microbiome (the collection of bacteria that live in people\u2019s bodies) to find other microbes that might have a similar effect on this pathway and explore those for new therapies tied to appetite loss and treating disease. The lab also wants to investigate whether drugs could be used to turn up or down the sickness-induced appetite-loss pathway that SlrP targets.<\/p>\n<p>\u201cNow that we\u2019d identified this mechanism that regulates appetite, we want to turn it on the flip side and see if we can decrease appetite via this mechanism to help in cases of metabolic disease,\u201d says Ayres.<\/p>\n<p>The discovery also points to the tantalizing possibility of treating infectious diseases with approaches other than antibiotics, such as nutritional intervention. \u201cFinding alternatives to antibiotics is incredibly important as these drugs have already encouraged the evolution of deadly antibiotic-resistant strains,\u201d says Ayres. In the United States alone, two million people annually become infected with bacteria that are resistant to antibiotics and at least 23,000 people die each year as a direct result of these infections, according to the U.S. <a href=\"https:\/\/www.cdc.gov\/\" target=\"_blank\" rel=\"noopener\">Centers for Disease Control<\/a>.<\/p>\n<p>Other researchers on the study were Alexandria M. Palaferri Schieber, Carolyn P. O\u2019Connor, Mathias Leblanc and Daniela Michel of the Salk Institute.<\/p>\n<p>The work and the researchers involved were supported by grants from the <a href=\"https:\/\/www.nih.gov\/\" target=\"_blank\" rel=\"noopener\">Nationale Gesundheitsinstitute<\/a>, der <a href=\"http:\/\/nomisfoundation.ch\/\" target=\"_blank\" rel=\"noopener\">Nomis Foundation<\/a>, der <a href=\"http:\/\/www.searlescholars.net\/\" target=\"_blank\" rel=\"noopener\">Searle-Stipendiaten-Stiftung<\/a> und die <a href=\"http:\/\/www.edwardsfoundation.org\/\" target=\"_blank\" rel=\"noopener\">Ray Thomas Edward Stiftung<\/a>.<\/p>","protected":false},"featured_media":12229,"template":"","faculty":[79],"disease-research":[122,366],"class_list":["post-12210","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-janelle-ayres","disease-research-immune-system-biology","disease-research-infectious-disease"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Feed a cold, starve a fever? Not so fast, according to Salk research - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Feed a cold, starve a fever? Not so fast, according to Salk research - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014The last time you had a stomach bug, you probably didn\u2019t feel much like eating. This loss of appetite is part of your body\u2019s normal response to an illness but is not well understood. Sometimes eating less during illness promotes a faster recovery, but other times\u2014such as when cancer patients experience wasting\u2014the loss of appetite can be deadly.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/de\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-30T23:31:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-featured.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"767\" \/>\n\t<meta property=\"og:image:height\" content=\"767\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/feed-cold-starve-fever-not-fast-according-salk-research\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/feed-cold-starve-fever-not-fast-according-salk-research\\\/\",\"name\":\"Feed a cold, starve a fever? Not so fast, according to Salk research - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/feed-cold-starve-fever-not-fast-according-salk-research\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/feed-cold-starve-fever-not-fast-according-salk-research\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2017\\\/01\\\/salmonella-typhimurium-featured.jpg\",\"datePublished\":\"2017-01-26T08:00:30+00:00\",\"dateModified\":\"2024-01-30T23:31:44+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/feed-cold-starve-fever-not-fast-according-salk-research\\\/#breadcrumb\"},\"inLanguage\":\"de-DE\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/feed-cold-starve-fever-not-fast-according-salk-research\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de-DE\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/feed-cold-starve-fever-not-fast-according-salk-research\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2017\\\/01\\\/salmonella-typhimurium-featured.jpg\",\"contentUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2017\\\/01\\\/salmonella-typhimurium-featured.jpg\",\"width\":767,\"height\":767},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/feed-cold-starve-fever-not-fast-according-salk-research\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Feed a cold, starve a fever? Not so fast, according to Salk research\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de-DE\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de-DE\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Feed a cold, starve a fever? Not so fast, according to Salk research - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/de\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/","og_locale":"de_DE","og_type":"article","og_title":"Feed a cold, starve a fever? Not so fast, according to Salk research - Salk Institute for Biological Studies","og_description":"LA JOLLA\u2014The last time you had a stomach bug, you probably didn\u2019t feel much like eating. This loss of appetite is part of your body\u2019s normal response to an illness but is not well understood. Sometimes eating less during illness promotes a faster recovery, but other times\u2014such as when cancer patients experience wasting\u2014the loss of appetite can be deadly.","og_url":"https:\/\/www.salk.edu\/de\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/","og_site_name":"Salk Institute for Biological Studies","article_modified_time":"2024-01-30T23:31:44+00:00","og_image":[{"width":767,"height":767,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-featured.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/","url":"https:\/\/www.salk.edu\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/","name":"Feed a cold, starve a fever? Not so fast, according to Salk research - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.salk.edu\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/#primaryimage"},"image":{"@id":"https:\/\/www.salk.edu\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/#primaryimage"},"thumbnailUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-featured.jpg","datePublished":"2017-01-26T08:00:30+00:00","dateModified":"2024-01-30T23:31:44+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/#breadcrumb"},"inLanguage":"de-DE","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/"]}]},{"@type":"ImageObject","inLanguage":"de-DE","@id":"https:\/\/www.salk.edu\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/#primaryimage","url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-featured.jpg","contentUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-featured.jpg","width":767,"height":767},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/feed-cold-starve-fever-not-fast-according-salk-research\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"Feed a cold, starve a fever? Not so fast, according to Salk research"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"Salk-Institut f\u00fcr biologische Studien","description":"Die Macht der Wissenschaft","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"de-DE"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"Salk-Institut f\u00fcr biologische Studien","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"de-DE","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"hero":"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/salmonella-typhimurium-header.jpg","line_1":"Feed a cold, starve a fever? Not so fast, according to Salk research","line_2":"Discovery into how bacteria control a host\u2019s hunger points to new ways to treat infections and appetite loss","gallery":false,"paper_url":"http:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(17)30054-5","journal_title":"Cell","paper_author_list":"Sheila Rao, Alexandria M. Palaferri Schieber, Carolyn P. O\u2019Connor, Mathias Leblanc, Daniela Michel, Janelle S. Ayres","paper_title":"Pathogen-mediated inhibition of anorexia promotes host survival and transmission","subhead":"Discovery into how bacteria control a host\u2019s hunger points to new ways to treat infections and appetite loss","home_photo":"","listing_photo":"","legacy_boilerplate":[],"hide_boilerplate":[],"disable_date":false,"listing_excerpt":"","descriptive_blurb":"","poster_quote":"","doi":"","has_journal_cover":false,"og_image_override":false},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure\/12210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":14,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure\/12210\/revisions"}],"predecessor-version":[{"id":47070,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure\/12210\/revisions\/47070"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/media\/12229"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/media?parent=12210"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/faculty?post=12210"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disease-research?post=12210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}