{"id":11250,"date":"2016-10-17T11:18:53","date_gmt":"2016-10-17T18:18:53","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=11250"},"modified":"2016-10-18T10:21:29","modified_gmt":"2016-10-18T17:21:29","slug":"salk-professor-awarded-multimillion-nih-pioneer-award-innovations-cell-biology","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/salk-professor-awarded-multimillion-nih-pioneer-award-innovations-cell-biology\/","title":{"rendered":"Salk professor awarded multimillion dollar NIH Pioneer Award for innovations in cell biology"},"content":{"rendered":"

LA JOLLA\u2014Salk Professor Juan Carlos Izpisua Belmonte<\/a> has been awarded a 2016 National Institutes of Health Pioneer Award, a highly coveted grant that supports the most innovative biomedical research, for his work in stem cell biology and regeneration.<\/p>\n

\"Belmonte-Web\"
Juan Carlos Izpisua Belmonte<\/p>\n

Click here for a high-resolution image<\/a><\/p>\n

Kredit: Salk Institut<\/figcaption><\/figure>\n

This grant, which will award at least $2.5 million in direct costs over 5 years, supports “individual scientists of exceptional creativity who propose pioneering and highly innovative approaches with the potential to produce an unusually high impact on biomedical or behavioral research.\u201d The grant will fund Izpisua Belmonte\u2019s lab in attempting to generate functional primate organs and tissues in vivo in a large animal host, the pig, using novel stem cell technologies his team has developed and recently discovered gene-editing technologies.<\/p>\n

\u201cThis research promises to shed important light on early development and could one day lead to new methods for growing transplantable human tissues,\u201d says Salk President Elizabeth Blackburn<\/a>.<\/p>\n

Izpisua Belmonte and colleagues published work in the journal Natur<\/em> last year reporting that they had been able to integrate human stem cells into early-stage mouse embryos so that the human stem cells began the first stages of differentiation\u2014they appeared to begin the process of generating precursors of the body\u2019s various tissues and organs. If their technique pans out, it could help overcome a major hurdle to organ transplants: the risk that the recipient\u2019s body will reject the new organ. He believes they may be able to get around this obstacle with advances in generating stem cells from patient cells that have already developed into a specific type of tissue, such as skin. Researchers can now take a person\u2019s skin cells, use chemicals to revert them back into what\u2019s called induced pluripotent stem cells (iPSCs), and then coax those reprogrammed stem cells to turn into desired tissue-specific cells, such as those of the brain, muscle or pancreas. If a person\u2019s iPSCs were used to grow an organ in an animal, the organ might pose less risk for rejection because the cells have the same DNA as the original patient skin cell.<\/p>\n

\u201cIf we can tell the human iPSCs in an animal host to develop into a kidney or other organ, for example, it could provide an entirely new source for transplant tissues,\u201d says Izpisua Belmonte. \u201cWe\u2019re still in the early stage of determining if this is possible and whether human cells can participate in the early formation of tissues in the host animal and become part of their development. Additionally, this technology could provide a novel research model by which we transplant cells in vivo to study a disease and its progression from the onset, as well as directly test how effective new therapies are.\u201d<\/p>\n

Izpisua Belmonte graduated from the University of Valencia, Spain<\/a>, with a bachelor\u2019s degree in pharmacy and science, and he earned a master\u2019s degree in pharmacology from the same university before completing his PhD in biochemistry and pharmacology at the University of Bologna, Italy<\/a>, and the University of Valencia. He then was a postdoctoral fellow at the European Molecular Biology Laboratory<\/a> (EMBL) in Heidelberg, Germany, and the University of California, Los Angeles<\/a>, prior to moving to the Salk Institute in 1993 where he has been since. From 2005-14 he was also director of the Center of Regenerative Medicine<\/a> in Barcelona.<\/p>","protected":false},"featured_media":5314,"template":"","faculty":[85],"disease-research":[],"class_list":["post-11250","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-juan-carlos-izpisua-belmonte"],"acf":[],"yoast_head":"\nSalk professor awarded multimillion dollar NIH Pioneer Award for innovations in cell biology - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/salk-professor-awarded-multimillion-nih-pioneer-award-innovations-cell-biology\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk professor awarded multimillion dollar NIH Pioneer Award for innovations in cell biology - 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