{"id":10284,"date":"2016-06-27T11:36:13","date_gmt":"2016-06-27T18:36:13","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=10284"},"modified":"2016-06-27T16:20:42","modified_gmt":"2016-06-27T23:20:42","slug":"cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells\/","title":{"rendered":"Cannabinoids remove plaque-forming Alzheimer\u2019s proteins from brain cells"},"content":{"rendered":"

LA JOLLA\u2013Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer-Krankheit<\/a>.<\/p>\n

While these exploratory studies were conducted in neurons grown in the laboratory, they may offer insight into the role of inflammation in Alzheimer\u2019s disease and could provide clues to developing novel therapeutics for the disorder.<\/p>\n

\u201cAlthough other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer\u2019s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells,\u201d says Salk Professor David Schubert<\/a>, the senior author of the paper.<\/p>\n

Alzheimer\u2019s disease is a progressive brain disorder that leads to memory loss and can seriously impair a person\u2019s ability to carry out daily tasks. It affects more than five million Americans according to the National Institutes of Health, and is a leading cause of death. It is also the most common cause of dementia and its incidence is expected to triple during the next 50 years.<\/p>\n

It has long been known that amyloid beta accumulates within the nerve cells of the aging brain well before the appearance of Alzheimer\u2019s disease symptoms and plaques. Amyloid beta is a major component of the plaque deposits that are a hallmark of the disease. But the precise role of amyloid beta and the plaques it forms in the disease process remains unclear.<\/p>\n

\"David-Schubert\"
David Schubert, Professor of Salk’s Cellular Neurobiology Laboratory <\/p>\n

Klicken Sie hier<\/a> for a high resolution image<\/p>\n

Kredit: Salk Institut<\/figcaption><\/figure>\n

In a manuscript published in June 2016\u2019s Aging and Mechanisms of Disease<\/a><\/em>, the Salk team studied nerve cells altered to produce high levels of amyloid beta to mimic aspects of Alzheimer\u2019s disease.<\/p>\n

The researchers found that high levels of amyloid beta were associated with cellular inflammation and higher rates of neuron death. They demonstrated that exposing the cells to THC reduced amyloid beta protein levels and eliminated the inflammatory response from the nerve cells caused by the protein, thereby allowing the nerve cells to survive.<\/p>\n

\u201cInflammation within the brain is a major component of the damage associated with Alzheimer\u2019s disease, but it has always been assumed that this response was coming from immune-like cells in the brain, not the nerve cells themselves,\u201d says Antonio Currais, a postdoctoral researcher in Schubert\u2019s laboratory and first author of the paper. \u201cWhen we were able to identify the molecular basis of the inflammatory response to amyloid beta, it became clear that THC-like compounds that the nerve cells make themselves may be involved in protecting the cells from dying.\u201d<\/p>\n

Brain cells have switches known as receptors that can be activated by endocannabinoids, a class of lipid molecules made by the body that are used for intercellular signaling in the brain. The psychoactive effects of marijuana are caused by THC, a molecule similar in activity to endocannabinoids that can activate the same receptors. Physical activity results in the production of endocannabinoids and some studies have shown that exercise may slow the progression of Alzheimer\u2019s disease.<\/p>\n

Schubert emphasized that his team\u2019s findings were conducted in exploratory laboratory models, and that the use of THC-like compounds as a therapy would need to be tested in clinical trials.<\/p>\n

In separate but related research, his lab found an Alzheimer\u2019s drug candidate called J147 that also removes amyloid beta from nerve cells and reduces the inflammatory response in both nerve cells and the brain. It was the study of J147 that led the scientists to discover that endocannabinoids are involved in the removal of amyloid beta and the reduction of inflammation.<\/p>\n

Other authors on the paper include Oswald Quehenberger and Aaron Armando at the University of California, San Diego<\/a>; and Pamela Maher and Daniel Daughtery at the Salk Institute.<\/p>\n

The study was supported by the Nationale Gesundheitsinstitute<\/a>, The Burns Foundation and The Bundy Foundation.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[113],"disease-research":[124],"class_list":["post-10284","disclosure","type-disclosure","status-publish","hentry","faculty-dave-schubert","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"\nCannabinoids remove plaque-forming Alzheimer\u2019s proteins from brain cells - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cannabinoids remove plaque-forming Alzheimer\u2019s proteins from brain cells - 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