The Stem Cell Core Facility (STEM) functions as a multi-user shared research facility dedicated to supporting work involving hES and human iPS cells. The STEM core maintains and provides well-characterized human embryonic stem (hES) cell lines and human induced pluripotent stem (iPS) cell lines, and provides the physical space, validated reagents and hands on training for scientist to use these pluripotent cells for their research goals. The Core staff has experience carrying out reprogramming experiments and has dedicated space for working with viral vectors.

In addition to providing all the cells, reagents and equipment necessary for stem cell culture, the Core Director and staff provide Salk researchers with individualized training for the culture, differentiation and reprogramming techniques specific to pluripotent human stem cells. They are available for consultation on experimental design, and can assist in getting projects involving hES (or iPS) cells moving quickly. The facility is centrally located on the Salk campus, making it convenient for Salk researchers to 'drop in' to care for their hES cell cultures while staying within easy reach of their home laboratories. The STEM Core is free of federal funding making it a safe haven for research involving either the NIH registered non-NIH registered human ES cell lines.