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Salk/Fondation Ipsen/Nature 2013
Meeting Program

Salk/Fondation Ipsen/Nature Symposium on Biological Complexity

January 16-­‐18, 2013

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Time Session
Wednesday 01/16/2013
Noon Registration
3:45 PM Welcome: Inder Verma
4:00 PM
Sydney Brenner Nobel Lecture
Nora Volkow
Network instability in Addiction
5:00 PM Reception
6:00 PM Session I: CLINICAL Ray DePaulo, Chair
Cathy Lord, Judith Rapoport, Eric Courchesne
9:00 PM Social Hour
Thursday 01/17/2013
8:00 AM Breakfast
9:00 AM Session II: GENETICS I (AUTISM) Daniel Geschwind, Chair
Evan Eichler, Michael Miller, Thomas Bourgeron, Jasmine Plummer, Matt State
12:30 PM Poster Session and Lunch
5:30 PM Dinner
6:30 PM Session III: GENETICS II
David Porteous, Chair
Pamela Sklar, Xianjin Zhou, Kathleen Merikangas, John Kelsoe, Bruno Conti
9:00 PM Social Hour
Friday 01/18/2013
8:00 AM Breakfast
9:00 AM Session IV: MECHANISMS Helen Mayberg, Chair
Karl Deisseroth, Michael J. McCarthy, Eric Nestler, Ricardo Gil-da-Costa, Ron Duman
12:30 PM Poster Session and Lunch
Mark Bear, Chair
David Goldstein, J. Tiago Goncalves, Ben Philpot
6:00 PM Gala Dinner & Lecture: Steven E. Hyman



SESSION I: CLINICAL Wednesday, January 16 - 6:00 pm
Ray DePaulo The Johns Hopkins University School of Medicine - Complexity Squared: The Modern Disease Model in a Post-Modern Clinic
Catherine Lord Weill Cornell Medical College - What Does a Biologist Need to Know About Autism?
Judith L. Rapoport National Institute of Mental Health, NIH - Childhood Onset Schizophrenia: Rare but Worth Studying
Eric Courchesne University of California, San Diego
Neural Developmental Genomic, Cellular and Cortical Organization Defects that Lead to Autism

SESSION II: GENETICS I (AUTISM) Thursday, January 17 - 9:00 am
Daniel Geschwind University of California, Los Angeles - Transcriptional Networks in Autism
Evan E. Eichler University of Washington - Autism: New Mutations, Genes and Genetic Models
*Michael J. Miller University of California, San Diego - Do The Eyes Have It? Apraxia and Oculomotor Control in Autism
Thomas Bourgeron Institut Pasteur, France - Genetic Buffering and Synaptic Homeostasis in Autism Spectrum Disorders
*Jasmine Plummer University of Southern California - Transcriptional Regulation of the MET Receptor Tyrosine Kinase Gene by MeCP2 and Sex-specific Brain Expression in Autism Spectrum Disorders
Matthew State Yale University - De Novo Mutation and the Emerging Biology of Autism Spectrum Disorders

David Porteous University of Edinburg, United Kingdom Insights into Major Mental Illness from the Genetics and Biology of the DISC1 Pathway
Pamela Sklar The Mount Sinai Hospital - Population and Family-based Exome Sequencing Studies of Schizophrenia
*Xianjin Zhou University of California, San Diego DISC1-Boymaw Fusion Proteins may Contribute to Pathogenesis of Major Psychiatric Disorders in the Scottish Schizophrenia Family
Kathleen R. Merikangas National Institute of Mental Health, NIH - Independence of Familial Transmission of Mania and Depression: Results of the NIMH Community Family Study of Affective Spectrum Disorders
John R. Kelsoe University of California, San Diego - Unraveling the Complexity of Bipolar Genetics
*Bruno Conti The Scripps Research Institute - IL-13Ra1 as Novel Immunomodulator of Dopaminergic Function

SESSION IV: MECHANISMS Friday, January 18 - 9:00 am
Helen Mayberg Emory University - Multimodal Assessment of Deep Brain Stimulation Effects in Treatment-Resistant Depression
Karl Deisseroth Stanford University - Optical Deconstruction of Fully-assembled Biological Systems
*Michael J. McCarthy University of California, San Diego - Circadian Clock Gene Expression Rhythms in Cells from Patients with Bipolar Disorder Differ by Genotype and Clinical Features in Response to Lithium
Eric J. Nestler Mount Sinai School of Medicine - New Insight into the Neurobiology of Depression
*Ricardo Gil-da-Costa Salk Institute for Biological Studies Support for a Non-Human Primate Model of Schizophrenia: Acute Subanesthetic Ketamine Reduces Mismatch Negativity and P3 ERPs
Ronald S. Duman Yale University Role of mTOR Signaling and Synaptogenesis in the Response to Rapid Acting Antidepressants and Pathophysiology of Depression

Friday, January 18 - 2:00 pm
Mark Bear Massachusetts Institute of Technology - Pathophysiology and Treatment of Fragile X and Related Disorders
David Goldstein Duke University - Genome-wide Identification of Pathogenic Mutations in Patients with Neuropsychiatric Disease
*J. Tiago Goncalves Salk Institute for Biological Studies - Early Network Activity is Disrupted in the Neocortex of Fragile X Mice
Ben Philpot University of North Carolina, Chapel Hill - A New Angle on Angelman Syndrome Therapeutics

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