Sreekanth Chalasani, PhD

Professor

Molecular Neurobiology Laboratory

Salk Institute for Biological Studies - Publications

all Publications


Cowen, M.H., Reddy, K.C., Chalasani, S.H., Hart, M.P. Conserved autism-associated genes tune social feeding behavior in . (2023) bioRxiv. DOI: 10.1101/2023.12.05.570116

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Pribadi, A., Rieger, M.A., Rosales, K., Reddy, K.C., Chalasani, S.H. Dopamine signaling regulates predator-driven changes in egg laying behavior. (2023) Elife. 12. DOI: 10.7554/eLife.83957

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Procko, C., Wong, W.M., Patel, J., Mousavi, S.A.R., Dabi, T., Duque, M., Baird, L., Chalasani, S.H., Chory, J. Mutational analysis of mechanosensitive ion channels in the carnivorous Venus flytrap plant. (2023) Current Biology. DOI: 10.1016/j.cub.2023.06.048

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Magaram, U., Weiss, C., Vasan, A., Reddy, K.C., Friend, J., Chalasani, S.H. Two pathways are required for ultrasound-evoked behavioral changes in Caenorhabditis elegans. (2022) PLOS One. 17(5):e0267698. DOI: 10.1371/journal.pone.0267698

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Matty, M.A., Lau, H.E., Haley, J.A., Singh, A., Chakraborty, A., Kono, K., Reddy, K.C., Hansen, M., Chalasani, S.H. Intestine-to-neuronal signaling alters risk-taking behaviors in food-deprived Caenorhabditis elegans. (2022) PLOS Genetics. 18(5):e1010178. DOI: 10.1371/journal.pgen.1010178

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Mei, J., Vasan, A., Magaram, U., Takemura, K., Chalasani, S.H., Friend, J. Well-free agglomeration and on-demand three-dimensional cell cluster formation using guided surface acoustic waves through a couplant layer. (2022) Biomed Microdevices. 24(2):18. DOI: 10.1007/s10544-022-00617-z

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Vasan, A., Allein, F., Duque, M., Magaram, U., Boechler, N., Chalasani, S.H., Friend, J. Microscale concert hall acoustics to produce uniform ultrasound stimulation for targeted sonogenetics in hsTRPA1-transfected cells. (2022) Adv Nanobiomed Res. 2(5). DOI: 10.1002/anbr.202100135

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Quach, K.T., Chalasani, S.H. Flexible reprogramming of Pristionchus pacificus motivation for attacking Caenorhabditis elegans in predator-prey competition. (2022) Current Biology. DOI: 10.1016/j.cub.2022.02.033

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Duque, M., Lee-Kubli, C.A., Tufail, Y., Magaram, U., Patel, J., Chakraborty, A., Mendoza Lopez, J., Edsinger, E., Vasan, A., Shiao, Weiss, C., Friends, J., Chalasani, S.H. Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels (2022) Nature Communications. 13. DOI: https://doi.org/10.1038/s41467-022-28205-y

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Vasan, A., Orosco, J., Magaram, U., Duque, M., Weiss, C., Tufail, Y., Chalasani, S.H., Friend, J. Ultrasound Mediated Cellular Deflection Results in Cellular Depolarization. (2021) Advanced Science .:e2101950 DOI: 10.1002/advs.202101950

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How, J.J., Navlakha, S., Chalasani, S.H. Neural network features distinguish chemosensory stimuli in Caenorhabditis elegans. (2021) PLOS Computational Biology. 17(11):e1009591. DOI: 10.1371/journal.pcbi.1009591

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Prakash, D., Ms, A., Radhika, B., Venkatesan, R., Chalasani, S.H., Singh, V. 1-Undecene from Pseudomonas aeruginosa is an olfactory signal for flight-or-fight response in Caenorhabditis elegans. (2021) EMBO Journal.:e106938 DOI: 10.15252/embj.2020106938

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Quach, K.T., Chalasani, S.H. Intraguild predation between and : a complex interaction with the potential for aggressive behaviour. (2020) Journal of Neurogenetics.:1-16 DOI: 10.1080/01677063.2020.1833004

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Matty, M.A., Chalasani, S.H. Microbial Mind Control. (2020) Cell Host & Microbe. 28(2):147-149. DOI: 10.1016/j.chom.2020.07.016

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Liu, Z., Kariya, M.J., Chute, C.D., Pribadi, A.K., Leinwand, S.G., Tong, A., Curran, K.P., Bose, N., Schroeder, F.C., Srinivasan, J., Chalasani, S.H. Predator-secreted sulfolipids induce defensive responses in C. elegans. (2018) Nature Communications. 9(1):1128. DOI: 10.1038/s41467-018-03333-6

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Hale, L.A., Lee, E.S., Pantazis, A.K., Chronis, N., Chalasani, S.H. Altered Sensory Code Drives Juvenile-to-Adult Behavioral Maturation in Caenorhabditis elegans. (2017) eNeuro. 3(6). DOI: 10.1523/ENEURO.0175-16.2016

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Leinwand, S.G., Yang, C.J., Bazopoulou, D., Chronis, N., Srinivasan, J., Chalasani, S.H. Circuit mechanisms encoding odors and driving aging-associated behavioral declines in Caenorhabditis elegans. (2015) Elife. 4:e10181. DOI: 10.7554/eLife.10181

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Ibsen, S., Tong, A., Schutt, C., Esener, S., Chalasani, S.H. Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans. (2015) Nature Communications. 6:8264. DOI: 10.1038/ncomms9264

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Calhoun, A.J., Tong, A., Pokala, N., Fitzpatrick, J.A., Sharpee, T.O., Chalasani, S.H. Neural Mechanisms for Evaluating Environmental Variability in Caenorhabditis elegans. (2015) Neuron. 86(2):428-41. DOI: 10.1016/j.neuron.2015.03.026

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Erickstad, M., Hale, L.A., Chalasani, S.H., Groisman, A. A microfluidic system for studying the behavior of zebrafish larvae under acute hypoxia. (2015) Lab on a Chip. 15(3):857-66. DOI: 10.1039/c4lc00717d

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Calhoun, A.J., Chalasani, S.H., Sharpee, T.O. Maximally informative foraging by Caenorhabditis elegans. (2014) Elife. 3. DOI: 10.7554/eLife.04220

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Lau, H.E., Chalasani, S.H. Divergent and convergent roles for insulin-like peptides in the worm, fly and mammalian nervous systems. (2014) Invertebrate Neuroscience. 14(2):71-8. DOI: 10.1007/s10158-013-0166-9

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Sharpee, T.O., Calhoun, A.J., Chalasani, S.H. Information theory of adaptation in neurons, behavior, and mood. (2014) Current Opinion in Neurobiology. 25:47-53. DOI: 10.1016/j.conb.2013.11.007

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Leinwand, S.G., Chalasani, S.H. From genes to circuits and behaviors: Neuropeptides expand the coding potential of the nervous system. (2014) Worm. 3:e27730. DOI: 10.4161/worm.27730

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Joens, M.S., Huynh, C., Kasuboski, J.M., Ferranti, D., Sigal, Y.J., Zeitvogel, F., Obst, M., Burkhardt, C.J., Curran, K.P., Chalasani, S.H., Stern, L.A., Goetze, B., Fitzpatrick, J.A. Helium Ion Microscopy (HIM) for the imaging of biological samples at sub-nanometer resolution. (2013) Scientific Reports. 3:3514. DOI: 10.1038/srep03514

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Leinwand, S.G., Chalasani, S.H. Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans. (2013) Nature Neuroscience. 16(10):1461-7. DOI: 10.1038/nn.3511

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Curran, K.P., Chalasani, S.H. Serotonin circuits and anxiety: what can invertebrates teach us? (2012) Invertebrate Neuroscience. 12(2):81-92. DOI: 10.1007/s10158-012-0140-y

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Leinwand, S.G., Chalasani, S.H. Olfactory networks: from sensation to perception. (2011) Current Opinion in Genetics & Development. 21(6):806-11. DOI: 10.1016/j.gde.2011.07.006

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Chalasani, S.H., Kato, S., Albrecht, D.R., Nakagawa, T., Abbott, L.F., Bargmann, C.I. Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans olfactory neurons. (2010) Nature Neuroscience. 13(5):615-21. DOI: 10.1038/nn.2526

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Tian, L., Hires, S.A., Mao, T., Huber, D., Chiappe, M.E., Chalasani, S.H., Petreanu, L., Akerboom, J., McKinney, S.A., Schreiter, E.R., Bargmann, C.I., Jayaraman, V., Svoboda, K., Looger, L.L. Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. (2009) Nature Methods. 6(12):875-81. DOI: 10.1038/nmeth.1398

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Macosko, E.Z., Pokala, N., Feinberg, E.H., Chalasani, S.H., Butcher, R.A., Clardy, J., Bargmann, C.I. A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans. (2009) Nature. 458(7242):1171-5. DOI: 10.1038/nature07886

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Tsunozaki, M., Chalasani, S.H., Bargmann, C.I. A behavioral switch: cGMP and PKC signaling in olfactory neurons reverses odor preference in C. elegans. (2008) Neuron. 59(6):959-71. DOI: 10.1016/j.neuron.2008.07.038

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Chalasani, S.H., Chronis, N., Tsunozaki, M., Gray, J.M., Ramot, D., Goodman, M.B., Bargmann, C.I. Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans. (2007) Nature. 450(7166):63-70. DOI: 10.1038/nature06292

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Chalasani, S.H., Feinberg, E.H., Hilliard, M.A. Global 'worming'. (2007) Genome Biology. 8(9):314. DOI: 10.1186/gb-2007-8-9-314


Chalasani, S.H., Sabol, A., Xu, H., Gyda, M.A., Rasband, K., Granato, M., Chien, C.B., Raper, J.A. Stromal cell-derived factor-1 antagonizes slit/robo signaling in vivo. (2007) Journal of Neuroscience. 27(5):973-80. DOI: 10.1523/JNEUROSCI.4132-06.2007

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Kreibich, T.A., Chalasani, S.H., Raper, J.A. The neurotransmitter glutamate reduces axonal responsiveness to multiple repellents through the activation of metabotropic glutamate receptor 1. (2004) Journal of Neuroscience. 24(32):7085-95. DOI: 10.1523/JNEUROSCI.0349-04.2004

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Vatamaniuk, O.K., Mari, S., Lang, A., Chalasani, S., Demkiv, L.O., Rea, P.A. Phytochelatin synthase, a dipeptidyltransferase that undergoes multisite acylation with gamma-glutamylcysteine during catalysis: stoichiometric and site-directed mutagenic analysis of arabidopsis thal (2004) Journal of Biological Chemistry. 279(21):22449-60. DOI: 10.1074/jbc.M313142200

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Chalasani, S.H., Baribaud, F., Coughlan, C.M., Sunshine, M.J., Lee, V.M., Doms, R.W., Littman, D.R., Raper, J.A. The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells. (2003) Journal of Neuroscience. 23(11):4601-12. DOI: https://doi.org/10.1523/JNEUROSCI.23-11-04601.2003

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Chalasani, S.H., Sabelko, K.A., Sunshine, M.J., Littman, D.R., Raper, J.A. A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding. (2003) Journal of Neuroscience. 23(4):1360-71. DOI: https://doi.org/10.1523/JNEUROSCI.23-04-01360.2003

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Pribadi, A.K., Chalasani, S.H. Fear conditioning in invertebrates. (n.d.) Front Behav Neurosci. 16:1008818. DOI: 10.3389/fnbeh.2022.1008818

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Education

BS, Genetics, Zoology, and Chemistry, Osmania University, India
ADV DIP, Computer Science, National Institute of Information Technology
PhD, Biology, University of Pennsylvania
Postdoctoral Fellow, Rockefeller University (lab moved from UCSF)


Affiliations


Awards & Honors

  • National Postdoctoral Association (NPA) Gallagher Mentor Award, 2021
  • National Institutes of Health Brain Initiative Awardee, 2016
  • Glenn Award for Research in Biological Mechanisms of Aging, 2015
  • W.M. Keck Foundation Award, 2013
  • Rita Allen Foundation Scholar, 2012
  • The March of Dimes Basil O’connor Award, 2010
  • Searle Scholar, 2010