Professor and Director
Gene Expression Laboratory
March of Dimes Chair in Molecular and Developmental Biology
Home - Science - Directory - Faculty - Ronald Evans, PhD - Publications
Hong, S.H., Castro, G., Wang, D., Nofsinger, R., Kane, M., Folias, A., Atkins, A.R., Yu, R.T., Napoli, J.L., Sassone-Corsi, P., de Rooij, D.G., Liddle, C., Downes, M., Evans, R.M. Targeting nuclear receptor corepressors for reversible male contraception. (2024) Proceedings of the National Academy of Sciences of the United States of America. 121(9):e2320129121. DOI: 10.1073/pnas.2320129121
Abe, Y., Kofman, E.R., Ouyang, Z., Cruz-Becerra, G., Spann, N.J., Seidman, J.S., Troutman, T.D., Stender, J.D., Taylor, H., Fan, W., Link, V.M., Shen, Z., Sakai, J., Downes, M., Evans, R.M., Kadonaga, J.T., Rosenfeld, M.G., Glass, C.K. A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation. (2024) Proceedings of the National Academy of Sciences of the United States of America. 121(2):e2316104121. DOI: 10.1073/pnas.2316104121
Xia, W., Veeragandham, P., Cao, Y., Xu, Y., Rhyne, T.E., Qian, J., Hung, C.W., Zhao, P., Jones, Y., Gao, H., Liddle, C., Yu, R.T., Downes, M., Evans, R.M., Rydén, M., Wabitsch, M., Wang, Z., Hakozaki, H., Schöneberg, J., Reilly, S.M., Huang, J., Saltiel, A.R. Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. (2024) Nat Metab. DOI: 10.1038/s42255-024-00978-0
Liang, G., Oh, T.G., Hah, N., Tiriac, H., Shi, Y., Truitt, M.L., Antal, C.E., Atkins, A.R., Li, Y., Fraser, C., Ng, S., Pinto, A.F.M., Nelson, D.C., Estepa, G., Bashi, S., Banayo, E., Dai, Y., Liddle, C., Yu, R.T., Hunter, T., Engle, D.D., Han, H., Von Hoff, D.D., Downes, M., Evans, R.M. Inhibiting stromal Class I HDACs curbs pancreatic cancer progression. (2023) Nature Communications. 14(1):7791. DOI: 10.1038/s41467-023-42178-6
Xu, W., Billon, C., Li, H., Wilderman, A., Qi, L., Graves, A., Rideb, J.R.D.C., Zhao, Y., Hayes, M., Yu, K., Losby, M., Hampton, C.S., Adeyemi, C.M., Hong, S.J., Nasiotis, E., Fu, C., Oh, T.G., Fan, W., Downes, M., Welch, R.D., Evans, R.M., Milosavljevic, A., Walker, J.K., Jensen, B.C., Pei, L., Burris, T., Zhang, L. Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function. (2023) Circulation. DOI: 10.1161/CIRCULATIONAHA.123.066542
Antal, C.E., Oh, T.G., Aigner, S., Luo, E.C., Yee, B.A., Campos, T., Tiriac, H., Rothamel, K.L., Cheng, Z., Jiao, H., Wang, A., Hah, N., Lenkiewicz, E., Lumibao, J.C., Truitt, M.L., Estepa, G., Banayo, E., Bashi, S., Esparza, E., Munoz, R.M., Diedrich, J.K., Sodir, N.M., Mueller, J.R., Fraser, C.R., Borazanci, E., Propper, D., Von Hoff, D.D., Liddle, C., Yu, R.T., Atkins, A.R., Han, H., Lowy, A.M., Barrett, M.T., Engle, D.D., Evan, G.I., Yeo, G.W., Downes, M., Evans, R.M. A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. (2023) Nature Communications. 14(1):5195. DOI: 10.1038/s41467-023-40798-6
Abe, Y., Kofman, E.R., Almeida, M., Ouyang, Z., Ponte, F., Mueller, J.R., Cruz-Becerra, G., Sakai, M., Prohaska, T.A., Spann, N.J., Resende-Coelho, A., Seidman, J.S., Stender, J.D., Taylor, H., Fan, W., Link, V.M., Cobo, I., Schlachetzki, J.C.M., Hamakubo, T., Jepsen, K., Sakai, J., Downes, M., Evans, R.M., Yeo, G.W., Kadonaga, J.T., Manolagas, S.C., Rosenfeld, M.G., Glass, C.K. RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression. (2023) Molecular Cell. DOI: 10.1016/j.molcel.2023.08.029
Kim, M.Y., Shin, H.Y., Cho, S.C., Yang, S., Intisar, A., Woo, H.J., Choi, Y.S., You, C.L., Kang, J.S., Lee, Y.I., Park, S.C., Yea, K., Oh, T.G., Downes, M., Evans, R.M., Kim, M.S. Silver electroceutical technology to treat sarcopenia. (2023) Proceedings of the National Academy of Sciences of the United States of America. 120(33):e2300036120. DOI: 10.1073/pnas.2300036120
Fu, T., Huan, T., Rahman, G., Zhi, H., Xu, Z., Oh, T.G., Guo, J., Coulter, S., Tripathi, A., Martino, C., McCarville, J.L., Zhu, Q., Cayabyab, F., Low, B., He, M., Xing, S., Vargas, F., Yu, R.T., Atkins, A., Liddle, C., Ayres, J., Raffatellu, M., Dorrestein, P.C., Downes, M., Knight, R., Evans, R.M. Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression. (2023) Cell Reports.:112997 DOI: 10.1016/j.celrep.2023.112997
Kushwaha, P., Tran, A., Quintero, D., Song, M., Yu, Q., Yu, R., Downes, M., Evans, R.M., Babst-Kostecka, A., Schroeder, J.I., Maier, R.M. Zinc accumulation in Atriplex lentiformis is driven by plant genes and the soil microbiome. (2023) Science of the Total Environment.:165667 DOI: 10.1016/j.scitotenv.2023.165667
Xia, W., Veeragandham, P., Cao, Y., Xu, Y., Rhyne, T., Qian, J., Hung, C.W., Zhao, P., Jones, Y., Gao, H., Liddle, C., Yu, R., Downes, M., Evans, R., Ryden, M., Wabitsch, M., Reilly, S., Huang, J., Saltiel, A. Obesity-dependent increase in RalA activity disrupts mitochondrial dynamics in white adipocytes. (2023) Res Sq. DOI: 10.21203/rs.3.rs-2923510/v1
Yoon, B.K., Kim, H., Oh, T.G., Oh, S.K., Jo, S., Kim, M., Chun, K.H., Hwang, N., Lee, S., Jin, S., Atkins, A.R., Yu, R.T., Downes, M., Kim, J.W., Kim, H., Evans, R.M., Cheong, J.H., Fang, S. PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress. (2023) Proceedings of the National Academy of Sciences of the United States of America. 120(21):e2217826120. DOI: 10.1073/pnas.2217826120
Billon, C., Sitaula, S., Banerjee, S., Welch, R., Elgendy, B., Hegazy, L., Oh, T.G., Kazantzis, M., Chatterjee, A., Chrivia, J., Hayes, M.E., Xu, W., Hamilton, A., Huss, J.M., Zhang, L., Walker, J.K., Downes, M., Evans, R.M., Burris, T.P. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. (2023) ACS Chemical Biology. DOI: 10.1021/acschembio.2c00720
Fu, T., Li, Y., Oh, T.G., Cayabyab, F., He, N., Tang, Q., Coulter, S., Truitt, M., Medina, P., He, M., Yu, R.T., Atkins, A., Zheng, Y., Liddle, C., Downes, M., Evans, R.M. FXR mediates ILC-intrinsic responses to intestinal inflammation. (2022) Proceedings of the National Academy of Sciences of the United States of America. 119(51):e2213041119. DOI: 10.1073/pnas.2213041119
Nies, V.J.M., Struik, D., Liu, S., Liu, W., Kruit, J.K., Downes, M., van Zutphen, T., Verkade, H.J., Evans, R.M., Jonker, J.W. Autocrine FGF1 signaling promotes glucose uptake in adipocytes. (2022) Proceedings of the National Academy of Sciences of the United States of America. 119(40):e2122382119. DOI: 10.1073/pnas.2122382119
Sharpton, S.R., Oh, T.G., Madamba, E., Wang, C., Yu, R.T., Atkins, A.R., Huan, T., Downes, M., Evans, M.R., Loomba, R. Gut metagenome-derived signature predicts hepatic decompensation and mortality in NAFLD-related cirrhosis. (2022) Aliment Pharmacol Ther. DOI: 10.1111/apt.17236
Huang, D., Downes, M., Evans, R., Witztum, J., Glass, C., Loomba, R. Shared mechanisms between cardiovascular disease and NAFLD. (2022) Semin Liver Dis. DOI: 10.1055/a-1930-6658
Kim, J.Y., Wang, L.Q., Sladky, V.C., Oh, T.G., Liu, J., Trinh, K., Eichin, F., Downes, M., Hosseini, M., Jacotot, E.D., Evans, R.M., Villunger, A., Karin, M. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. (2022) Cell Metabolism. DOI: 10.1016/j.cmet.2022.08.005
Giguere, V., Evans, R.M. Chronicle of a discovery: the retinoic acid receptor. (2022) Journal of Molecular Endocrinology. DOI: 10.1530/JME-22-0117
Gasser, E., Sancar, G., Downes, M., Evans, R.M. Metabolic Messengers: fibroblast growth factor 1. (2022) Nat Metab. DOI: 10.1038/s42255-022-00580-2
Shi, Y., Evans, R.M., Gage, F.H. Oleic acid regulates hippocampal neurogenesis as a TLX ligand. (2022) Proceedings of the National Academy of Sciences of the United States of America. 119(15):e2203038119. DOI: 10.1073/pnas.2203038119
Choi, J., Oh, T.G., Jung, H., Park, K.Y., Shin, H., Jo, T., Kang, D.S., Chanda, D., Hong, S., Kim, J., Hwang, H., Ji, M., Jung, M., Takashihoji, Matsushima, A., Kim, P., Mun, J.Y., Paik, M.J., Cho, S.J., Lee, I.K., Whitcomb, D.C., Greer, P., Blobner, B., Goodarzi, M.O., Pandol, S.J., Rotter, J.I., Fan, W., Bapat, S.P., Zheng, Y., Liddle, C., Yu, R.T., Atkins, A.R., Downes, M., Yoshihara, E., Evans, R.M., Suh, J.M. Estrogen-Related Receptor γ maintains pancreatic acinar cell function and identity by regulating cellular metabolism. (2022) Gastroenterology. DOI: 10.1053/j.gastro.2022.04.013
Casanova-Vallve, N., Duglan, D., Vaughan, M.E., Pariollaud, M., Handzlik, M.K., Fan, W., Yu, R.T., Liddle, C., Downes, M., Delezie, J., Mello, R., Chan, A.B., Westermark, P.O., Metallo, C.M., Evans, R.M., Lamia, K.A. Daily running enhances molecular and physiological circadian rhythms in skeletal muscle. (2022) Molecular Metabolism.:101504 DOI: 10.1016/j.molmet.2022.101504
Bapat, S.P., Whitty, C., Mowery, C.T., Liang, Y., Yoo, A., Jiang, Z., Peters, M.C., Zhang, L.J., Vogel, I., Zhou, C., Nguyen, V.Q., Li, Z., Chang, C., Zhu, W.S., Hastie, A.T., He, H., Ren, X., Qiu, W., Gayer, S.G., Liu, C., Choi, E.J., Fassett, M., Cohen, J.N., Sturgill, J.L., Crotty Alexander, L.E., Suh, J.M., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Liu, S., Nikolajczyk, B.S., Lee, I.K., Guttman-Yassky, E., Ansel, K.M., Woodruff, P.G., Fahy, J.V., Sheppard, D., Gallo, R.L., Ye, C.J., Evans, R.M., Zheng, Y., Marson, A. Obesity alters pathology and treatment response in inflammatory disease. (2022) Nature. 604(7905):337-342. DOI: 10.1038/s41586-022-04536-0
Yang, L., TeSlaa, T., Ng, S., Nofal, M., Wang, L., Lan, T., Zeng, X., Cowan, A., McBride, M., Lu, W., Davidson, S., Liang, G., Oh, T.G., Downes, M., Evans, R., Von Hoff, D., Guo, J.Y., Han, H., Rabinowitz, J.D. Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth. (2022) Med (N Y). 3(2):119-136. DOI: 10.1016/j.medj.2021.12.008
Ahmed, N.S., Gatchalian, J., Ho, J., Burns, M.J., Hah, N., Wei, Z., Downes, M., Evans, R.M., Hargreaves, D.C. BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4. (2022) Proceedings of the National Academy of Sciences of the United States of America. 119(1). DOI: 10.1073/pnas.2110812119
Sancar, G., Liu, S., Gasser, E., Alvarez, J.G., Moutos, C., Kim, K., van Zutphen, T., Wang, Y., Huddy, T.F., Ross, B., Dai, Y., Zepeda, D., Collins, B., Tilley, E., Kolar, M.J., Yu, R.T., Atkins, A.R., van Dijk, T.H., Saghatelian, A., Jonker, J.W., Downes, M., Evans, R.M. FGF1 and insulin control lipolysis by convergent pathways. (2022) Cell Metabolism. 34(1):171-183.e6. DOI: 10.1016/j.cmet.2021.12.004
Evans, R.M., Wei, Z. Inter-organ Crosstalk in Pancreatic Islet Function and Pathology. (2022) FEBS Lett. DOI: 10.1002/1873-3468.14282
Valentine, J.M., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M.P., Gao, H., Yu, R.T., Liddle, C., Downes, M., Zhang, J., Lusis, A.J., Attie, A.D., Evans, R.M., Rydén, M., Saltiel, A.R. β3-adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. (2021) Journal of Clinical Investigation. DOI: 10.1172/JCI153357
Keinan, O., Valentine, J.M., Xiao, H., Mahata, S.K., Reilly, S.M., Abu-Odeh, M., Deluca, J.H., Dadpey, B., Cho, L., Pan, A., Yu, R.T., Dai, Y., Liddle, C., Downes, M., Evans, R.M., Lusis, A.J., Laakso, M., Chouchani, E.T., Ryde'n, M., Saltiel, A.R. Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes. (2021) Nature. DOI: 10.1038/s41586-021-04019-8
Iwamoto, M., Masuya, T., Hosose, M., Tagawa, K., Ishibashi, T., Yoshihara, E., Downes, M., Evans, R.M., Matsushima, A. Bisphenol A derivatives act as novel coactivator binding inhibitors for estrogen receptor β. (2021) Journal of Biological Chemistry.:101173 DOI: 10.1016/j.jbc.2021.101173
Tang, Q., Evans, R.M. Colon cancer checks in when bile acids check out: the bile acid-nuclear receptor axis in colon cancer. (2021) Essays Biochem. DOI: 10.1042/EBC20210038
Wang, L., Oh, T.G., Magida, J., Estepa, G., Obayomi, S.M.B., Chong, L.W., Gatchalian, J., Yu, R.T., Atkins, A.R., Hargreaves, D., Downes, M., Wei, Z., Evans, R.M. Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(35). DOI: 10.1073/pnas.2109517118
Liu, S., Kim, D.I., Oh, T.G., Pao, G.M., Kim, J.H., Palmiter, R.D., Banghart, M.R., Lee, K.F., Evans, R.M., Han, S. Neural basis of opioid-induced respiratory depression and its rescue. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(23). DOI: 10.1073/pnas.2022134118
Abu-Odeh, M., Zhang, Y., Reilly, S.M., Ebadat, N., Keinan, O., Valentine, J.M., Hafezi-Bakhtiari, M., Ashayer, H., Mamoun, L., Zhou, X., Zhang, J., Yu, R.T., Dai, Y., Liddle, C., Downes, M., Evans, R.M., Kliewer, S.A., Mangelsdorf, D.J., Saltiel, A.R. FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. (2021) Cell Reports. 35(13):109331. DOI: 10.1016/j.celrep.2021.109331
Xu, S., Chaudhary, O., Rodríguez-Morales, P., Sun, X., Chen, D., Zappasodi, R., Xu, Z., Pinto, A.F.M., Williams, A., Schulze, I., Farsakoglu, Y., Varanasi, S.K., Low, J.S., Tang, W., Wang, H., McDonald, B., Tripple, V., Downes, M., Evans, R.M., Abumrad, N.A., Merghoub, T., Wolchok, J.D., Shokhirev, M.N., Ho, P.C., Witztum, J.L., Emu, B., Cui, G., Kaech, S.M. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8 T cells in tumors. (2021) Immunity. DOI: 10.1016/j.immuni.2021.05.003
Oh, T.G., Kim, S.M., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M. Proton pump inhibitor use status does not modify the microbiome signature for cirrhosis. (2021) Cell Metabolism. 33(3):457. DOI: 10.1016/j.cmet.2021.02.013
Zhou, R., Llorente, C., Cao, J., Zaramela, L.S., Zeng, S., Gao, B., Li, S.Z., Welch, R.D., Huang, F.Q., Qi, L.W., Pan, C., Huang, Y., Zhou, P., Beussen, I., Zhang, Y., Bryam, G., Fiehn, O., Wang, L., Liu, E.H., Yu, R.T., Downes, M., Evans, R.M., Goglin, K., Fouts, D.E., Brenner, D.A., Bode, L., Fan, X., Zengler, K., Schnabl, B. Intestinal α1-2-fucosylation contributes to obesity and steatohepatitis in mice. (2021) Cell Mol Gastroenterol Hepatol. DOI: 10.1016/j.jcmgh.2021.02.009
Noel, P., Hussein, S., Ng, S., Antal, C.E., Lin, W., Rodela, E., Delgado, P., Naveed, S., Downes, M., Lin, Y., Evans, R.M., Von Hoff, D.D., Han, H. Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts. (2020) Oncogenesis. 9(11):100. DOI: 10.1038/s41389-020-00285-9
Evans, R.M., Lippman, S.M. Shining Light on the COVID-19 Pandemic: A Vitamin D Receptor Checkpoint in Defense of Unregulated Wound Healing. (2020) Cell Metabolism. DOI: 10.1016/j.cmet.2020.09.007
Lenkiewicz, E., Malasi, S., Hogenson, T.L., Flores, L.F., Barham, W., Phillips, W.J., Roesler, A.S., Chambers, K.R., Rajbhandari, N., Hayashi, A., Antal, C.E., Downes, M., Grandgenett, P.M., Hollingsworth, M.A., Cridebring, D., Xiong, Y., Lee, J.H., Ye, Z., Yan, H., Hernandez, M.C., Leiting, J.L., Evans, R.M., Ordog, T., Truty, M.J., Borad, M.J., Reya, T., Von Hoff, D.D., Fernandez-Zapico, M.E., Barrett, M.T. Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas. (2020) Cancer Research. DOI: 10.1158/0008-5472.CAN-20-0078
Yoshihara, E., O'Connor, C., Gasser, E., Wei, Z., Oh, T.G., Tseng, T.W., Wang, D., Cayabyab, F., Dai, Y., Yu, R.T., Liddle, C., Atkins, A.R., Downes, M., Evans, R.M. Immune-evasive human islet-like organoids ameliorate diabetes. (2020) Nature. DOI: 10.1038/s41586-020-2631-z
Oh, T.G., Kim, S.M., Caussy, C., Fu, T., Guo, J., Bassirian, S., Singh, S., Madamba, E.V., Bettencourt, R., Richards, L., Raffatellu, M., Dorrestein, P.C., Yu, R.T., Atkins, A.R., Huan, T., Brenner, D.A., Sirlin, C.B., Knight, R., Downes, M., Evans, R.M., Loomba, R. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. (2020) Cell Metabolism. DOI: 10.1016/j.cmet.2020.06.005
Paschoal, V.A., Walenta, E., Talukdar, S., Pessentheiner, A.R., Osborn, O., Hah, N., Chi, T.J., Tye, G.L., Armando, A.M., Evans, R.M., Chi, N.W., Quehenberger, O., Olefsky, J.M., Oh, D.Y. Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity. (2020) Cell Metabolism. DOI: 10.1016/j.cmet.2020.04.020
Seidman, J.S., Troutman, T.D., Sakai, M., Gola, A., Spann, N.J., Bennett, H., Bruni, C.M., Ouyang, Z., Li, R.Z., Sun, X., Vu, B.T., Pasillas, M.P., Ego, K.M., Gosselin, D., Link, V.M., Chong, L.W., Evans, R.M., Thompson, B.M., McDonald, J.G., Hosseini, M., Witztum, J.L., Germain, R.N., Glass, C.K. Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. (2020) Immunity. DOI: 10.1016/j.immuni.2020.04.001
Quinn, R.A., Melnik, A.V., Vrbanac, A., Fu, T., Patras, K.A., Christy, M.P., Bodai, Z., Belda-Ferre, P., Tripathi, A., Chung, L.K., Downes, M., Welch, R.D., Quinn, M., Humphrey, G., Panitchpakdi, M., Weldon, K.C., Aksenov, A., da Silva, R., Avila-Pacheco, J., Clish, C., Bae, S., Mallick, H., Franzosa, E.A., Lloyd-Price, J., Bussell, R., Thron, T., Nelson, A.T., Wang, M., Leszczynski, E., Vargas, F., Gauglitz, J.M., Meehan, M.J., Gentry, E., Arthur, T.D., Komor, A.C., Poulsen, O., Boland, B.S., Chang, J.T., Sandborn, W.J., Lim, M., Garg, N., Lumeng, J.C., Xavier, R.J., Kazmierczak, B.I., Jain, R., Egan, M., Rhee, K.E., Ferguson, D., Raffatellu, M., Vlamakis, H., Haddad, G.G., Siegel, D., Huttenhower, C., Mazmanian, S.K., Evans, R.M., Nizet, V., Knight, R., Dorrestein, P.C. Global chemical effects of the microbiome include new bile-acid conjugations. (2020) Nature. DOI: 10.1038/s41586-020-2047-9
Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D.G., Egeblad, M., Evans, R.M., Fearon, D., Greten, F.R., Hingorani, S.R., Hunter, T., Hynes, R.O., Jain, R.K., Janowitz, T., Jorgensen, C., Kimmelman, A.C., Kolonin, M.G., Maki, R.G., Powers, R.S., Puré, E., Ramirez, D.C., Scherz-Shouval, R., Sherman, M.H., Stewart, S., Tlsty, T.D., Tuveson, D.A., Watt, F.M., Weaver, V., Weeraratna, A.T., Werb, Z. A framework for advancing our understanding of cancer-associated fibroblasts. (2020) Nature Reviews Cancer. DOI: 10.1038/s41568-019-0238-1
Sun, X., Seidman, J.S., Zhao, P., Troutman, T.D., Spann, N.J., Que, X., Zhou, F., Liao, Z., Pasillas, M., Yang, X., Magida, J.A., Kisseleva, T., Brenner, D.A., Downes, M., Evans, R.M., Saltiel, A.R., Tsimikas, S., Glass, C.K., Witztum, J.L. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. (2019) Cell Metabolism. 31:189–206. DOI: 10.1016/j.cmet.2019.10.014
Cai, D., Wang, J., Gao, B., Li, J., Wu, F., Zou, J.X., Xu, J., Jiang, Y., Zou, H., Huang, Z., Borowsky, A.D., Bold, R.J., Lara, P.N., Li, J.J., Chen, X., Lam, K.S., To, K.F., Kung, H.J., Fiehn, O., Zhao, R., Evans, R.M., Chen, H.W. RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. (2019) Nature Communications. 10(1):4621. DOI: 10.1038/s41467-019-12529-3
Chang, C., Loo, C.S., Zhao, X., Solt, L.A., Liang, Y., Bapat, S.P., Cho, H., Kamenecka, T.M., Leblanc, M., Atkins, A.R., Yu, R.T., Downes, M., Burris, T.P., Evans, R.M., Zheng, Y. The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease. (2019) Proceedings of the National Academy of Sciences of the United States of America. 116(37):18528-18536. DOI: 10.1073/pnas.1907563116
Wang, L., Mazagova, M., Pan, C., Yang, S., Brandl, K., Liu, J., Reilly, S.M., Wang, Y., Miao, Z., Loomba, R., Lu, N., Guo, Q., Liu, J., Yu, R.T., Downes, M., Evans, R.M., Brenner, D.A., Saltiel, A.R., Beutler, B., Schnabl, B. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. (2019) Proceedings of the National Academy of Sciences of the United States of America. 116(30):15184-15193. DOI: 10.1073/pnas.1904360116
Shi, Y., Gao, W., Lytle, N.K., Huang, P., Yuan, X., Dann, A.M., Ridinger-Saison, M., DelGiorno, K.E., Antal, C.E., Liang, G., Atkins, A.R., Erikson, G., Sun, H., Meisenhelder, J., Terenziani, E., Woo, G., Fang, L., Santisakultarm, T.P., Manor, U., Xu, R., Becerra, C.R., Borazanci, E., Von Hoff, D.D., Grandgenett, P.M., Hollingsworth, M.A., Leblanc, M., Umetsu, S.E., Collisson, E.A., Scadeng, M., Lowy, A.M., Donahue, T.R., Reya, T., Downes, M., Evans, R.M., Wahl, G.M., Pawson, T., Tian, R., Hunter, T. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. (2019) Nature. 569(7754):131-135. DOI: 10.1038/s41586-019-1130-6
Auciello, F.R., Bulusu, V., Oon, C., Tait-Mulder, J., Berry, M., Bhattacharyya, S., Tumanov, S., Allen-Petersen, B.L., Link, J., Kendsersky, N.D., Vringer, E., Schug, M., Novo, D., Hwang, R.F., Evans, R.M., Nixon, C., Dorrell, C., Morton, J.P., Norman, J.C., Sears, R.C., Kamphorst, J.J., Sherman, M.H. A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. (2019) Cancer Discovery. 9(5):617-627. DOI: 10.1158/2159-8290.CD-18-1212
Caussy, C., Tripathi, A., Humphrey, G., Bassirian, S., Singh, S., Faulkner, C., Bettencourt, R., Rizo, E., Richards, L., Xu, Z.Z., Downes, M.R., Evans, R.M., Brenner, D.A., Sirlin, C.B., Knight, R., Loomba, R. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. (2019) Nature Communications. 10(1):1406. DOI: 10.1038/s41467-019-09455-9
Fu, F., Coulter, S., Yoshihara, E., Oh, T.G., Fang, S., Cayabyab, F., Zhu, Q., Zhang, T., Leblanc, M., Liu, He, M., Waizenegger, W., Gasser, E., Schnabl, B., Atkins, A.R., Yu, R.T., Knight, B., Liddle, C., Downes, Evans, M. FXR Regulates Intestinal Cancer Stem Cell Proliferation. (2019) Cell. 176(5):1098-1112. DOI: 10.1016/j.cell.2019.01.036
Hemmer, M.C., Wierer, M., Schachtrup, K., Downes, M., Hübner, N., Evans, R.M., Uhlenhaut, N.H. E47 modulates hepatic glucocorticoid action. (2019) Nature Communications. 10(1):306. DOI: 10.1038/s41467-018-08196-5
Cui, S., Li, L., Yu, R.T., Downes, M., Evans, R.M., Hulin, J.A., Makarenkova, H.P., Meech, R. β-catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin. (2019) Development. 146(6). DOI: 10.1242/dev.167080
Ward, J.M., Stoyas, C.A., Switonski, P.M., Ichou, F., Fan, W., Collins, B., Wall, C.E., Adanyeguh, I., Niu, C., Sopher, B.L., Kinoshita, C., Morrison, R.S., Durr, A., Muotri, A.R., Evans, R.M., Mochel, F., La Spada, A.R. Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease. (2019) Cell Reports. 26(5):1189-1202.e6. DOI: 10.1016/j.celrep.2019.01.028
Senagolage, M.D., Sommars, M.A., Ramachandran, K., Futtner, C.R., Omura, Y., Allred, A.L., Wang, J., Yang, C., Procissi, D., Evans, R.M., Han, X., Bederman, I.R., Barish, G.D. Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity. (2018) Cell Reports. 25(12):3283-3298.e6. DOI: 10.1016/j.celrep.2018.11.074
Elbel, E.E., Lavine, J.E., Downes, M., Van Natta, M., Yu, R., Schwimmer, J.B., Behling, C., Brunt, E.M., Tonascia, J., Evans, R. Hepatic Nuclear Receptor Expression Associates with Features of Histology in Pediatric Nonalcoholic Fatty Liver Disease. (2018) Hepatology Communications. 2(10):1213-1226. DOI: 10.1002/hep4.1232
Hong, S.H., Fang, S., Lu, B.C., Nofsinger, R., Kawakami, Y., Castro, G.L., Yin, Y., Lin, C., Yu, R.T., Downes, M., Izpisúa Belmonte, J.C., Shilatifard, A., Evans, R.M. Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. (2018) Proceedings of the National Academy of Sciences of the United States of America. 115(41):10381-10386. DOI: 10.1073/pnas.1809480115
Wei, Z., Yoshihara, E., He, N., Hah, N., Fan, W., Pinto, A.F.M., Huddy, T., Wang, Y., Ross, B., Estepa, G., Dai, Y., Ding, N., Sherman, M.H., Fang, S., Zhao, X., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M. Vitamin D Switches BAF Complexes to Protect β Cells. (2018) Cell. 173(5):1135-1149. DOI: 10.1016/j.cell.2018.04.013
Magida, J.A., Evans, R.M. Rational application of macrophage-specific LXR agonists avoids the pitfalls of SREBP-induced lipogenesis. (2018) Proceedings of the National Academy of Sciences of the United States of America. 115(20):5051-5053. DOI: 10.1073/pnas.1805128115
De Magalhaes Filho, C.D., Henriquez, B., Seah, N.E., Evans, R.M., Lapierre, L.R., Dillin, A. Visible light reduces C. elegans longevity. (2018) Nature Communications. 9(1):927. DOI: 10.1038/s41467-018-02934-5
Fan, W., He, N., Lin, C.S., Wei, Z., Hah, N., Waizenegger, W., He, M.X., Liddle, C., Yu, R.T., Atkins, A.R., Downes, M., Evans, R.M. ERRγ Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1α/β-Deficient Muscle. (2018) Cell Reports. 22(10):2521-2529. DOI: 10.1016/j.celrep.2018.02.047
Ahmadian, M., Liu, S., Reilly, S.M., Hah, N., Fan, W., Yoshihara, E., Jha, P., De Magalhaes Filho, C.D., Jacinto, S., Gomez, A.V., Dai, Y., Yu, R.T., Liddle, C., Atkins, A.R., Auwerx, J., Saltiel, A.R., Downes, M., Evans, R.M. ERRγ Preserves Brown Fat Innate Thermogenic Activity. (2018) Cell Reports. 22(11):2849-2859. DOI: 10.1016/j.celrep.2018.02.061
Shalom-Barak, T., Liersemann, J., Memari, B., Flechner, L., Devor, C., Bernardo, T.M., Kim, S., Matsumoto, N., Friedman, S.L., Evans, R.M., White, J.H., Barak, Y. Ligand-Dependent Corepressor (LCoR) Is A Rexinoid-Inhibited PPARγ-RXRα Coactivator. (2018) Molecular and Cellular Biology. 38(9). DOI: 10.1128/MCB.00107-17
Saison-Ridinger, M., DelGiorno, K.E., Zhang, T., Kraus, A., French, R., Jaquish, D., Tsui, C., Erikson, G., Spike, B.T., Shokhirev, M.N., Liddle, C., Yu, R.T., Downes, M., Evans, R.M., Saghatelian, A., Lowy, A.M., Wahl, G.M. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. (2017) PLOS One. 12(12):e0189051. DOI: 10.1371/journal.pone.0189051
Dickey, A.S., Sanchez, D.N., Arreola, M., Sampat, K.R., Fan, W., Arbez, N., Akimov, S., Van Kanegan, M.J., Ohnishi, K., Gilmore-Hall, S.K., Flores, A.L., Nguyen, J.M., Lomas, N., Hsu, C.L., Lo, D.C., Ross, C.A., Masliah, E., Evans, R.M., La Spada, A.R. PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. (2017) Science Translational Medicine. 9(419). DOI: 10.1126/scitranslmed.aal2332
Cao, Q., Zhao, X., Bai, J., Gery, S., Sun, H., Lin, D.C., Chen, Q., Chen, Z., Mack, L., Yang, H., Deng, R., Shi, X., Chong, L.W., Cho, H., Xie, J., Li, Q.Z., Müschen, M., Atkins, A.R., Liddle, C., Yu, R.T., Alkan, S., Said, J.W., Zheng, Y., Downes, M., Evans, R.M., Koeffler, H.P. Circadian clock cryptochrome proteins regulate autoimmunity. (2017) Proceedings of the National Academy of Sciences of the United States of America. 114(47):12548-12553. DOI: 10.1073/pnas.1619119114
He, N., Fan, W., Henriquez, B., Yu, R.T., Atkins, A.R., Liddle, C., Zheng, Y., Downes, M., Evans, R.M. Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. (2017) Proc. Natl. Acad. Sci. U.S.A. 114(47):12542-12547. DOI: 10.1073/pnas.1715363114
Shalapour, S., Lin, X.J., Bastian, I.N., Brain, J., Burt, A.D., Aksenov, A.A., Vrbanac, A.F., Li, W., Perkins, A., Matsutani, T., Zhong, Z., Dhar, D., Navas-Molina, J.A., Xu, J., Loomba, R., Downes, M., Yu, R.T., Evans, R.M., Dorrestein, P.C., Knight, R., Benner, C., Anstee, Q.M., Karin, M. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. (2017) Nature. 551(7680):340-345. DOI: 10.1038/nature24302
Hartmann, P., Hochrath, K., Horvath, A., Chen, P., Seebauer, C.T., Llorente, C., Wang, L., Alnouti, Y., Fouts, D.E., Stärkel, P., Loomba, R., Coulter, S., Liddle, C., Yu, R.T., Ling, L., Rossi, S.J., DePaoli, A.M., Downes, M., Evans, R.M., Brenner, D.A., Schnabl, B. Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice. (2017) Hepatology. 67(6):2150-2166. DOI: 10.1002/hep.29676
Shalapour, S., Lin, X.J., Bastian, I.N., Brain, J., Burt, A.D., Aksenov, A.A., Vrbanac, A.F., Li, W., Perkins, A., Matsutani, T., Zhong, Z., Dhar, D., Navas-Molina, J.A., Xu, J., Loomba, R., Downes, M., Yu, R.T., Evans, R.M., Dorrestein, P.C., Knight, R., Benner, C., Anstee, Q.M., Karin, M. Erratum: Inflammation-induced IgA(+) cells dismantle anti-liver cancer immunity. (2017) Nature. DOI: 10.1038/nature25028
Wang, J., He, N., Zhang, N., Quan, D., Zhang, S., Zhang, C., Yu, R.T., Atkins, A.R., Zhu, R., Yang, C., Cui, Y., Liddle, C., Downes, M., Xiao, H., Zheng, Y., Auwerx, J., Evans, R.M., Leng, Q. NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. (2017) Nature Communications. 8(1):959. DOI: 10.1038/s41467-017-00931-8
Kriebs, A., Jordan, S.D., Soto, E., Henriksson, E., Sandate, C.R., Vaughan, M.E., Chan, A.B., Duglan, D., Papp, S.J., Huber, A.L., Afetian, M.E., Yu, R.T., Zhao, X., Downes, M., Evans, R.M., Lamia, K.A. Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. (2017) Proceedings of the National Academy of Sciences of the United States of America. 114(33):8776-8781. DOI: 10.1073/pnas.1704955114
Jordan, S.D., Kriebs, A., Vaughan, M., Duglan, D., Fan, W., Henriksson, E., Huber, A.L., Papp, S.J., Nguyen, M., Afetian, M., Downes, M., Yu, R.T., Kralli, A., Evans, R.M., Lamia, K.A. CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity. (2017) Cell Metabolism. 26(1):243-255.e6. DOI: 10.1016/j.cmet.2017.06.002
Oral, E.A., Reilly, S.M., Gomez, A.V., Meral, R., Butz, L., Ajluni, N., Chenevert, T.L., Korytnaya, E., Neidert, A.H., Hench, R., Rus, D., Horowitz, J.F., Poirier, B., Zhao, P., Lehmann, K., Jain, M., Yu, R., Liddle, C., Ahmadian, M., Downes, M., Evans, R.M., Saltiel, A.R. Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. (2017) Cell Metabolism. 26(1):157-170.e7. DOI: 10.1016/j.cmet.2017.06.006
Evans, R.M. 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Short reflections on the discovery of the mineralocorticoid receptor. (2017) Journal of Endocrinology. 234(1):E1-E2. DOI: 10.1530/JOE-17-0287
Gasser, E., Moutos, C.P., Downes, M., Evans, R.M. FGF1 - a new weapon to control type 2 diabetes mellitus. (2017) Nature Reviews Endocrinology. 13(10):599-609. DOI: 10.1038/nrendo.2017.78
Liu, H., Naxerova, K., Pinter, M., Incio, J., Lee, H., Shigeta, K., Ho, W.W., Crain, J.A., Jacobson, A., Michelakos, T., Dias-Santos, D., Zanconato, A., Hong, T.S., Clark, J.W., Murphy, J.E., Ryan, D.P., Deshpande, V., Lillemoe, K.D., Fernandez-Del Castillo, C., Downes, M., Evans, R.M., Michaelson, J., Ferrone, C.R., Boucher, Y., Jain, R.K. Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma. (2017) Clinical Cancer Research. 23(19):5959-5969. DOI: 10.1158/1078-0432.CCR-17-0256
Fan, W., Waizenegger, W., Lin, C.S., Sorrentino, V., He, M.X., Wall, C.E., Li, H., Liddle, C., Yu, R.T., Atkins, A.R., Auwerx, J., Downes, M., Evans, R.M. PPARδ Promotes Running Endurance by Preserving Glucose. (2017) Cell Metabolism. 25(5):1186-1193.e4. DOI: 10.1016/j.cmet.2017.04.006
Doktorova, M., Zwarts, I., Zutphen, T.V., Dijk, T.H., Bloks, V.W., Harkema, L., Bruin, A., Downes, M., Evans, R.M., Verkade, H.J., Jonker, J.W. Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia. (2017) Scientific Reports. 7(1):846. DOI: 10.1038/s41598-017-00889-z
Evan, G.I., Hah, N., Littlewood, T.D., Sodir, N.M., Campos, T., Downes, M., Evans, R.M. Re-engineering the Pancreas Tumor Microenvironment: A "Regenerative Program" Hacked. (2017) Clinical Cancer Research. 23(7):1647-1655. DOI: 10.1158/1078-0432.CCR-16-3275
Wu, C.C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Fan, W., Stockley-Noel, T.A., Bowman, M.E., Noel, J.P., Evans, R.M. Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ. (2017) Proceedings of the National Academy of Sciences of the United States of America. 114(13):E2563-E2570. DOI: 10.1073/pnas.1621513114
De Magalhaes Filho, C.D., Downes, M., Evans, R.M. Farnesoid X Receptor an Emerging Target to Combat Obesity. (2017) Digestive Diseases. 35(3):185-190. DOI: 10.1159/000450909
Chen, S., Lu, W., Yueh, M.F., Rettenmeier, E., Liu, M., Auwerx, J., Yu, R.T., Evans, R.M., Wang, K., Karin, M., Tukey, R.H. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. (2017) Proceedings of the National Academy of Sciences of the United States of America. 114(8):E1432-E1440. DOI: 10.1073/pnas.1700232114
Fan, W., Evans, R.M. Exercise Mimetics: Impact on Health and Performance. (2017) Cell Metabolism. 25(2):242-247. DOI: 10.1016/j.cmet.2016.10.022
Sherman, M.H., Yu, R.T., Tseng, T.W., Sousa, C.M., Liu, S., Truitt, M.L., He, N., Ding, N., Liddle, C., Atkins, A.R., Leblanc, M., Collisson, E.A., Asara, J.M., Kimmelman, A.C., Downes, M., Evans, R.M. Stromal cues regulate the pancreatic cancer epigenome and metabolome. (2017) Proceedings of the National Academy of Sciences of the United States of America. 114(5):1129-1134. DOI: 10.1073/pnas.1620164114
Chung, H.K., Ryu, D., Kim, K.S., Chang, J.Y., Kim, Y.K., Yi, H.S., Kang, S.G., Choi, M.J., Lee, S.E., Jung, S.B., Ryu, M.J., Kim, S.J., Kweon, G.R., Kim, H., Hwang, J.H., Lee, C.H., Lee, S.J., Wall, C.E., Downes, M., Evans, R.M., Auwerx, J., Shong, M. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. (2017) Journal of Cell Biology. 216(1):149-165. DOI: 10.1083/jcb.201607110
Fu, T., Zhao, X., Evans, R.M. Liver Cancer Checks in When Bile Acid Clocks Out. (2016) Cancer Cell. 30(6):827-828. DOI: 10.1016/j.ccell.2016.11.012
Xia, X., Kumru, O.S., Blaber, S.I., Middaugh, C.R., Li, L., Ornitz, D.M., Suh, J.M., Atkins, A.R., Downes, M., Evans, R.M., Tenorio, C.A., Bienkiewicz, E., Blaber, M. An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities. (2016) Journal of Pharmaceutical Sciences. 105(12):3507-3519. DOI: 10.1016/j.xphs.2016.09.005
Evans, R.M., Wan, Y. Reply to "PPAR-γ regulates pharmacological but not physiological or pathological osteoclast formation". (2016) Nature Medicine. 22(11):1205. DOI: 10.1038/nm.4207
Fan, W., Evans, R. METABOLISM. The quest to burn fat, effortlessly and safely. (2016) Science. 353(6301):749-50. DOI: 10.1126/science.aah6189
De Magalhaes Filho, C.D., Downes, M., Evans, R. Bile Acid Analog Intercepts Liver Fibrosis. (2016) Cell. 166(4):789. DOI: 10.1016/j.cell.2016.08.001
Hulin, J.A., Nguyen, T.D., Cui, S., Marri, S., Yu, R.T., Downes, M., Evans, R.M., Makarenkova, H., Meech, R. Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with β-Catenin and Chromatin Remodelling. (2016) Stem Cells. 34(8):2169-82. DOI: 10.1002/stem.2396
Sousa, C.M., Biancur, D.E., Wang, X., Halbrook, C.J., Sherman, M.H., Zhang, L., Kremer, D., Hwang, R.F., Witkiewicz, A.K., Ying, H., Asara, J.M., Evans, R.M., Cantley, L.C., Lyssiotis, C.A., Kimmelman, A.C. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. (2016) Nature. 536(7617):479-83. DOI: 10.1038/nature19084
Eichenfield, D.Z., Troutman, T.D., Link, V.M., Lam, M.T., Cho, H., Gosselin, D., Spann, N.J., Lesch, H.P., Tao, J., Muto, J., Gallo, R.L., Evans, R.M., Glass, C.K. Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages. (2016) Elife. 5. DOI: 10.7554/eLife.13024
Wall, C.E., Yu, R.T., Atkins, A.R., Downes, M., Evans, R.M. Nuclear receptors and AMPK: can exercise mimetics cure diabetes? (2016) Journal of Molecular Endocrinology. 57(1):R49-58. DOI: 10.1530/JME-16-0073
Zhao, X., Hirota, T., Han, X., Cho, H., Chong, L.W., Lamia, K., Liu, S., Atkins, A.R., Banayo, E., Liddle, C., Yu, R.T., Yates, J.R., Kay, S.A., Downes, M., Evans, R.M. Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation. (2016) Cell. 165(7):1644-1657. DOI: 10.1016/j.cell.2016.05.012
Booth, D.R., Ding, N., Parnell, G.P., Shahijanian, F., Coulter, S., Schibeci, S.D., Atkins, A.R., Stewart, G.J., Evans, R.M., Downes, M., Liddle, C. Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases. (2016) Genes and Immunity. 17(4):213-9. DOI: 10.1038/gene.2016.12
Wang, J., Zou, J.X., Xue, X., Cai, D., Zhang, Y., Duan, Z., Xiang, Q., Yang, J.C., Louie, M.C., Borowsky, A.D., Gao, A.C., Evans, C.P., Lam, K.S., Xu, J., Kung, H.J., Evans, R.M., Xu, Y., Chen, H.W. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. (2016) Nature Medicine. 22(5):488-96. DOI: 10.1038/nm.4070
Yoshihara, E., Wei, Z., Lin, C.S., Fang, S., Ahmadian, M., Kida, Y., Tseng, T., Dai, Y., Yu, R.T., Liddle, C., Atkins, A.R., Downes, M., Evans, R.M. ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells. (2016) Cell Metabolism. 23(4):622-34. DOI: 10.1016/j.cmet.2016.03.005
Heldin, C.H., Lu, B., Evans, R., Gutkind, J.S. Signals and Receptors. (2016) Cold Spring Harbor Perspectives in Biology. 8(4):a005900. DOI: 10.1101/cshperspect.a005900
Zheng, X., Boyer, L., Jin, M., Kim, Y., Fan, W., Bardy, C., Berggren, T., Evans, R.M., Gage, F.H., Hunter, T. Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration. (2016) Elife. 5. DOI: 10.7554/eLife.13378
Liu, W., Struik, D., Nies, V.J., Jurdzinski, A., Harkema, L., de Bruin, A., Verkade, H.J., Downes, M., Evans, R.M., van Zutphen, T., Jonker, J.W. Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(8):2288-93. DOI: 10.1073/pnas.1525093113
Kim, J.A., Roy, R.R., Zhong, H., Alaynick, W.A., Embler, E., Jang, C., Gomez, G., Sonoda, T., Evans, R.M., Edgerton, V.R. PPARδ preserves a high resistance to fatigue in the mouse medial gastrocnemius after spinal cord transection. (2016) Muscle Nerve. 53(2):287-96. DOI: 10.1002/mus.24723
Nies, V.J., Sancar, G., Liu, W., van Zutphen, T., Struik, D., Yu, R.T., Atkins, A.R., Evans, R.M., Jonker, J.W., Downes, M.R. Fibroblast Growth Factor Signaling in Metabolic Regulation. (2016) Frontiers in Endocrinology. 6:193. DOI: 10.3389/fendo.2015.00193
Hah, N., Sherman, M.H., Yu, R.T., Downes, M., Evans, R.M. Targeting Transcriptional and Epigenetic Reprogramming in Stromal Cells in Fibrosis and Cancer. (2016) Cold Spring Harbor Symposia on Quantitative Biology. 80:249-55. DOI: 10.1101/sqb.2015.80.027185
Ding, N., Hah, N., Yu, R.T., Sherman, M.H., Benner, C., Leblanc, M., He, M., Liddle, C., Downes, M., Evans, R.M. BRD4 is a novel therapeutic target for liver fibrosis. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(51):15713-8. DOI: 10.1073/pnas.1522163112
Bapat, S.P., Myoung Suh, J., Fang, S., Liu, S., Zhang, Y., Cheng, A., Zhou, C., Liang, Y., LeBlanc, M., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M., Zheng, Y. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. (2015) Nature. 528(7580):137-41. DOI: 10.1038/nature16151
Arensman, M.D., Nguyen, P., Kershaw, K.M., Lay, A.R., Ostertag-Hill, C.A., Sherman, M.H., Downes, M., Liddle, C., Evans, R.M., Dawson, D.W. Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer. (2015) Molecular Cancer Research. 13(11):1509-19. DOI: 10.1158/1541-7786.MCR-15-0204
Jo, Y.S., Ryu, D., Maida, A., Wang, X., Evans, R.M., Schoonjans, K., Auwerx, J. Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. (2015) Hepatology. 62(5):1606-18. DOI: 10.1002/hep.27907
Schieber, A.M., Lee, Y.M., Chang, M.W., Leblanc, M., Collins, B., Downes, M., Evans, R.M., Ayres, J.S. Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling. (2015) Science. 350(6260):558-63. DOI: 10.1126/science.aac6468
Ranjit, S., Dvornikov, A., Stakic, M., Hong, S.H., Levi, M., Evans, R.M., Gratton, E. Imaging Fibrosis and Separating Collagens using Second Harmonic Generation and Phasor Approach to Fluorescence Lifetime Imaging. (2015) Scientific Reports. 5:13378. DOI: 10.1038/srep13378
Mounsey, R.B., Martin, H.L., Nelson, M.C., Evans, R.M., Teismann, P. The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson's disease. (2015) Neuroscience. 300:576-84. DOI: 10.1016/j.neuroscience.2015.05.048
Wall, C.E., Whyte, J., Suh, J.M., Fan, W., Collins, B., Liddle, C., Yu, R.T., Atkins, A.R., Naviaux, J.C., Li, K., Bright, A.T., Alaynick, W.A., Downes, M., Naviaux, R.K., Evans, R.M. High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(28):8714-9. DOI: 10.1073/pnas.1509930112
Fan, W., Evans, R.M. Turning up the heat on membrane fluidity. (2015) Cell. 161(5):962-3. DOI: 10.1016/j.cell.2015.04.046
Kida, Y.S., Kawamura, T., Wei, Z., Sogo, T., Jacinto, S., Shigeno, A., Kushige, H., Yoshihara, E., Liddle, C., Ecker, J.R., Yu, R.T., Atkins, A.R., Downes, M., Evans, R.M. ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency. (2015) Cell Stem Cell. 16(5):547-55. DOI: 10.1016/j.stem.2015.03.001
Pei, L., Mu, Y., Leblanc, M., Alaynick, W., Barish, G.D., Pankratz, M., Tseng, T.W., Kaufman, S., Liddle, C., Yu, R.T., Downes, M., Pfaff, S.L., Auwerx, J., Gage, F.H., Evans, R.M. Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism. (2015) Cell Metabolism. 21(4):628-36. DOI: 10.1016/j.cmet.2015.03.004
Wang, T., McDonald, C., Petrenko, N.B., Leblanc, M., Wang, T., Giguere, V., Evans, R.M., Patel, V.V., Pei, L. Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function. (2015) Molecular and Cellular Biology. 35(7):1281-98. DOI: 10.1128/MCB.01156-14
Fan, W., Evans, R. PPARs and ERRs: molecular mediators of mitochondrial metabolism. (2015) Current Opinion in Cell Biology. 33:49-54. DOI: 10.1016/j.ceb.2014.11.002
Morinaga, H., Mayoral, R., Heinrichsdorff, J., Osborn, O., Franck, N., Hah, N., Walenta, E., Bandyopadhyay, G., Pessentheiner, A.R., Chi, T.J., Chung, H., Bogner-Strauss, J.G., Evans, R.M., Olefsky, J.M., Oh, D.Y. Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. (2015) Diabetes. 64(4):1120-30. DOI: 10.2337/db14-1238
Hutchison, A.M., Topliss, C., Beard, D., Evans, R.M., Williams, P. The treatment of a rupture of the Achilles tendon using a dedicated management programme. (2015) Bone Joint J. 97-B(4):510-515. DOI: 10.1302/0301-620X.97B4.35314
Fang, S., Suh, J.M., Reilly, S.M., Yu, E., Osborn, O., Lackey, D., Yoshihara, E., Perino, A., Jacinto, S., Lukasheva, Y., Atkins, A.R., Khvat, A., Schnabl, B., Yu, R.T., Brenner, D.A., Coulter, S., Liddle, C., Schoonjans, K., Olefsky, J.M., Saltiel, A.R., Downes, M., Evans, R.M. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. (2015) Nature Medicine. 21(2):159-65. DOI: 10.1038/nm.3760
Reilly, S.M., Ahmadian, M., Zamarron, B.F., Chang, L., Uhm, M., Poirier, B., Peng, X., Krause, D.M., Korytnaya, E., Neidert, A., Liddle, C., Yu, R.T., Lumeng, C.N., Oral, E.A., Downes, M., Evans, R.M., Saltiel, A.R. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. (2015) Nature Communications. 6:6047. DOI: 10.1038/ncomms7047
Hah, N., Benner, C., Chong, L.W., Yu, R.T., Downes, M., Evans, R.M. Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(3):E297-302. DOI: 10.1073/pnas.1424028112
McKenna, N.J., Evans, R.M., O'Malley, B.W. Nuclear Receptor Signaling: a home for nuclear receptor and coregulator signaling research. (2014) Nuclear Receptor Signaling. 12:e006. DOI: 10.1621/nrs.12006
Yueh, M.F., Taniguchi, K., Chen, S., Evans, R.M., Hammock, B.D., Karin, M., Tukey, R.H. The commonly used antimicrobial additive triclosan is a liver tumor promoter. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(48):17200-5. DOI: 10.1073/pnas.1419119111
Williamson, J.J., Evans, R.M. Measuring local volume fraction, long-wavelength correlations, and fractionation in a phase-separating polydisperse fluid. (2014) J Chem Phys. 141(16):164901. DOI: 10.1063/1.4897560
Sherman, M.H., Yu, R.T., Engle, D.D., Ding, N., Atkins, A.R., Tiriac, H., Collisson, E.A., Connor, F., Van Dyke, T., Kozlov, S., Martin, P., Tseng, T.W., Dawson, D.W., Donahue, T.R., Masamune, A., Shimosegawa, T., Apte, M.V., Wilson, J.S., Ng, B., Lau, S.L., Gunton, J.E., Wahl, G.M., Hunter, T., Drebin, J.A., O'Dwyer, P.J., Liddle, C., Tuveson, D.A., Downes, M., Evans, R.M. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. (2014) Cell. 159(1):80-93. DOI: 10.1016/j.cell.2014.08.007
Takada, H., Saito, Y., Mituyama, T., Wei, Z., Yoshihara, E., Jacinto, S., Downes, M., Evans, R.M., Kida, Y.S. Methylome, transcriptome, and PPAR(γ) cistrome analyses reveal two epigenetic transitions in fat cells. (2014) Epigenetics. 9(9):1195-206. DOI: 10.4161/epi.29856
Suh, J.M., Jonker, J.W., Ahmadian, M., Goetz, R., Lackey, D., Osborn, O., Huang, Z., Liu, W., Yoshihara, E., van Dijk, T.H., Havinga, R., Fan, W., Yin, Y.Q., Yu, R.T., Liddle, C., Atkins, A.R., Olefsky, J.M., Mohammadi, M., Downes, M., Evans, R.M. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. (2014) Nature. 513(7518):436-9. DOI: 10.1038/nature13540
Lu, B., Bridges, D., Yang, Y., Fisher, K., Cheng, A., Chang, L., Meng, Z.X., Lin, J.D., Downes, M., Yu, R.T., Liddle, C., Evans, R.M., Saltiel, A.R. Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity. (2014) Diabetes. 63(9):2935-48. DOI: 10.2337/db13-1531
Korf, K., Wodrich, H., Haschke, A., Ocampo, C., Harder, L., Gieseke, F., Pollmann, A., Dierck, K., Prall, S., Staege, H., Ma, H., Horstmann, M.A., Evans, R.M., Sternsdorf, T. The PML domain of PML-RARα blocks senescence to promote leukemia. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(33):12133-8. DOI: 10.1073/pnas.1412944111
Oh, D.Y., Walenta, E., Akiyama, T.E., Lagakos, W.S., Lackey, D., Pessentheiner, A.R., Sasik, R., Hah, N., Chi, T.J., Cox, J.M., Powels, M.A., Di Salvo, J., Sinz, C., Watkins, S.M., Armando, A.M., Chung, H., Evans, R.M., Quehenberger, O., McNelis, J., Bogner-Strauss, J.G., Olefsky, J.M. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. (2014) Nature Medicine. 20(8):942-7. DOI: 10.1038/nm.3614
Daniel, B., Nagy, G., Hah, N., Horvath, A., Czimmerer, Z., Poliska, S., Gyuris, T., Keirsse, J., Gysemans, C., Van Ginderachter, J.A., Balint, B.L., Evans, R.M., Barta, E., Nagy, L. The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages. (2014) Genes & Development. 28(14):1562-77. DOI: 10.1101/gad.242685.114
Zhuang, L., Hulin, J.A., Gromova, A., Tran Nguyen, T.D., Yu, R.T., Liddle, C., Downes, M., Evans, R.M., Makarenkova, H.P., Meech, R. Barx2 and Pax7 have antagonistic functions in regulation of wnt signaling and satellite cell differentiation. (2014) Stem Cells. 32(6):1661-73. DOI: 10.1002/stem.1674
Zhao, X., Cho, H., Yu, R.T., Atkins, A.R., Downes, M., Evans, R.M. Nuclear receptors rock around the clock. (2014) EMBO Reports. 15(5):518-28. DOI: 10.1002/embr.201338271
Hong, S.H., Ahmadian, M., Yu, R.T., Atkins, A.R., Downes, M., Evans, R.M. Nuclear receptors and metabolism: from feast to famine. (2014) Diabetologia. 57(5):860-7. DOI: 10.1007/s00125-014-3209-9
Liu, S., Evans, R.M. Metabolism: Tick, tock, a high-fat clock. (2014) Nature Reviews Endocrinology. 10(4):191-2. DOI: 10.1038/nrendo.2014.23
d'Uscio, L.V., He, T., Santhanam, A.V., Tai, L.J., Evans, R.M., Katusic, Z.S. Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene. (2014) Am. J. Physiol. Heart Circ. Physiol. 306(7):H1001-10. DOI: 10.1152/ajpheart.00761.2013
Evans, R.M., Mangelsdorf, D.J. Nuclear Receptors, RXR, and the Big Bang. (2014) Cell. 157(1):255-66. DOI: 10.1016/j.cell.2014.03.012
Fan, W., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M. Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. (2013) Journal of Molecular Endocrinology. 51(3):T87-T100. DOI: 10.1530/JME-13-0258
Evans, R.M. Journal of Molecular Endocrinology 25th anniversary special issue. (2013) Journal of Molecular Endocrinology. 51(3):E1-3. DOI: 10.1530/JME-13-0257
Hong, S.H., Dvorak-Ewell, M., Stevens, H.Y., Barish, G.D., Castro, G.L., Nofsinger, R., Frangos, J.A., Shoback, D., Evans, R.M. Rescue of a primary myelofibrosis model by retinoid-antagonist therapy. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(47):18820-5. DOI: 10.1073/pnas.1318974110
Ding, N., Liddle, C., Evans, R.M., Downes, M. Hepatic actions of vitamin D receptor ligands: a sunshine option for chronic liver disease? (2013) Expert Rev Clin Pharmacol. 6(6):597-9. DOI: 10.1586/17512433.2013.841078
Kittayaruksakul, S., Zhao, W., Xu, M., Ren, S., Lu, J., Wang, J., Downes, M., Evans, R.M., Venkataramanan, R., Chatsudthipong, V., Xie, W. Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation. (2013) Pharmaceutical Research. 30(9):2199-208. DOI: 10.1007/s11095-013-1101-9
Fang, S., Evans, R.M. Microbiology: Wealth management in the gut. (2013) Nature. 500(7464):538-9. DOI: 10.1038/500538a
Lam, M.T., Cho, H., Lesch, H.P., Gosselin, D., Heinz, S., Tanaka-Oishi, Y., Benner, C., Kaikkonen, M.U., Kim, A.S., Kosaka, M., Lee, C.Y., Watt, A., Grossman, T.R., Rosenfeld, M.G., Evans, R.M., Glass, C.K. Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. (2013) Nature. 498(7455):511-5. DOI: 10.1038/nature12209
Martin, H.L., Mounsey, R.B., Sathe, K., Mustafa, S., Nelson, M.C., Evans, R.M., Teismann, P. A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. (2013) Neuroscience. 240:191-203. DOI: 10.1016/j.neuroscience.2013.02.058
Ahmadian, M., Suh, J.M., Hah, N., Liddle, C., Atkins, A.R., Downes, M., Evans, R.M. PPARγ signaling and metabolism: the good, the bad and the future. (2013) Nature Medicine. 19(5):557-66. DOI: 10.1038/nm.3159
Du, L., Bergsneider, M., Mirsadraei, L., Young, S.H., Jonker, J.W., Downes, M., Yong, W.H., Evans, R.M., Heaney, A.P. Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(21):8555-60. DOI: 10.1073/pnas.1306182110
Ding, N., Yu, R.T., Subramaniam, N., Sherman, M.H., Wilson, C., Rao, R., Leblanc, M., Coulter, S., He, M., Scott, C., Lau, S.L., Atkins, A.R., Barish, G.D., Gunton, J.E., Liddle, C., Downes, M., Evans, R.M. A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. (2013) Cell. 153(3):601-13. DOI: 10.1016/j.cell.2013.03.028
Reilly, S.M., Chiang, S.H., Decker, S.J., Chang, L., Uhm, M., Larsen, M.J., Rubin, J.R., Mowers, J., White, N.M., Hochberg, I., Downes, M., Yu, R.T., Liddle, C., Evans, R.M., Oh, D., Li, P., Olefsky, J.M., Saltiel, A.R. An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. (2013) Nature Medicine. 19(3):313-21. DOI: 10.1038/nm.3082
Chao, L.C., Soto, E., Hong, C., Ito, A., Pei, L., Chawla, A., Conneely, O.M., Tangirala, R.K., Evans, R.M., Tontonoz, P. Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice. (2013) Journal of Lipid Research. 54(3):806-15. DOI: 10.1194/jlr.M034157
Zhao, X., Cho, H., Evans, R.M. SRF'ing around the clock. (2013) Cell. 152(3):381-2. DOI: 10.1016/j.cell.2013.01.028
Uhlenhaut, N.H., Barish, G.D., Yu, R.T., Downes, M., Karunasiri, M., Liddle, C., Schwalie, P., Hübner, N., Evans, R.M. Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. (2013) Molecular Cell. 49(1):158-71. DOI: 10.1016/j.molcel.2012.10.013
Chao, L.C., Wroblewski, K., Ilkayeva, O.R., Stevens, R.D., Bain, J., Meyer, G.A., Schenk, S., Martinez, L., Vergnes, L., Narkar, V.A., Drew, B.G., Hong, C., Boyadjian, R., Hevener, A.L., Evans, R.M., Reue, K., Spencer, M.J., Newgard, C.B., Tontonoz, P. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. (2012) Journal of Lipid Research. 53(12):2610-9. DOI: 10.1194/jlr.M029355
Li, T., Yu, R.T., Atkins, A.R., Downes, M., Tukey, R.H., Evans, R.M. Targeting the pregnane X receptor in liver injury. (2012) Expert Opinion on Therapeutic Targets. 16(11):1075-83. DOI: 10.1517/14728222.2012.715634
Zhang, Y., Xie, Y., Berglund, E.D., Coate, K.C., He, T.T., Katafuchi, T., Xiao, G., Potthoff, M.J., Wei, W., Wan, Y., Yu, R.T., Evans, R.M., Kliewer, S.A., Mangelsdorf, D.J. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. (2012) Elife. 1:e00065. DOI: 10.7554/eLife.00065
Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D.E., Schafer, Z.T., Evans, R.M., Suda, T., Lee, C.H., Pandolfi, P.P. A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. (2012) Nature Medicine. 18(9):1350-8. DOI: 10.1038/nm.2882
Chen, S., Yueh, M.F., Evans, R.M., Tukey, R.H. Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice. (2012) Hepatology. 56(2):658-67. DOI: 10.1002/hep.25671
Yueh, M.F., Li, T., Evans, R.M., Hammock, B., Tukey, R.H. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. (2012) PLOS One. 7(6):e37705. DOI: 10.1371/journal.pone.0037705
Jonker, J.W., Suh, J.M., Atkins, A.R., Ahmadian, M., Li, P., Whyte, J., He, M., Juguilon, H., Yin, Y.Q., Phillips, C.T., Yu, R.T., Olefsky, J.M., Henry, R.R., Downes, M., Evans, R.M. A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. (2012) Nature. 485(7398):391-4. DOI: 10.1038/nature10998
Iwaisako, K., Haimerl, M., Paik, Y.H., Taura, K., Kodama, Y., Sirlin, C., Yu, E., Yu, R.T., Downes, M., Evans, R.M., Brenner, D.A., Schnabl, B. Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(21):E1369-76. DOI: 10.1073/pnas.1202464109
Barish, G.D., Yu, R.T., Karunasiri, M.S., Becerra, D., Kim, J., Tseng, T.W., Tai, L.J., Leblanc, M., Diehl, C., Cerchietti, L., Miller, Y.I., Witztum, J.L., Melnick, A.M., Dent, A.L., Tangirala, R.K., Evans, R.M. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. (2012) Cell Metabolism. 15(4):554-62. DOI: 10.1016/j.cmet.2012.02.012
Matsakas, A., Yadav, V., Lorca, S., Evans, R.M., Narkar, V.A. Revascularization of ischemic skeletal muscle by estrogen-related receptor-γ. (2012) Circulation research. 110(8):1087-96. DOI: 10.1161/CIRCRESAHA.112.266478
Subramaniam, N., Sherman, M.H., Rao, R., Wilson, C., Coulter, S., Atkins, A.R., Evans, R.M., Liddle, C., Downes, M. Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling. (2012) Cancer Prevention Research. 5(4):553-61. DOI: 10.1158/1940-6207.CAPR-12-0053
Li, M.D., Ruan, H.B., Singh, J.P., Zhao, L., Zhao, T., Azarhoush, S., Wu, J., Evans, R.M., Yang, X. O-GlcNAc transferase is involved in glucocorticoid receptor-mediated transrepression. (2012) Journal of Biological Chemistry. 287(16):12904-12. DOI: 10.1074/jbc.M111.303792
Noreault-Conti, T.L., Fellows, A., Jacobs, J.M., Trask, H.W., Strom, S.C., Evans, R.M., Wrighton, S.A., Sinclair, P.R., Sinclair, J.F., Nichols, R.C. Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes. (2012) International Immunopharmacology. 12(4):651-6. DOI: 10.1016/j.intimp.2012.01.008
Cho, H., Zhao, X., Hatori, M., Yu, R.T., Barish, G.D., Lam, M.T., Chong, L.W., DiTacchio, L., Atkins, A.R., Glass, C.K., Liddle, C., Auwerx, J., Downes, M., Panda, S., Evans, R.M. Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. (2012) Nature. 485(7396):123-7. DOI: 10.1038/nature11048
Evans, R. Wylie Walker Vale Jr (1941-2012). (2012) Nature. 483(7391):542. DOI: 10.1038/483542a
Shimozaki, K., Zhang, C.L., Suh, H., Denli, A.M., Evans, R.M., Gage, F.H. SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cells. (2012) Journal of Biological Chemistry. 287(8):5969-78. DOI: 10.1074/jbc.M111.290403
Panopoulos, A.D., Yanes, O., Ruiz, S., Kida, Y.S., Diep, D., Tautenhahn, R., Herrerías, A., Batchelder, E.M., Plongthongkum, N., Lutz, M., Berggren, W.T., Zhang, K., Evans, R.M., Siuzdak, G., Izpisua Belmonte, J.C. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. (2012) Cell Research. 22(1):168-77. DOI: 10.1038/cr.2011.177
Sherman, M.H., Downes, M., Evans, R.M. Nuclear receptors as modulators of the tumor microenvironment. (2012) Cancer Prevention Research. 5(1):3-10. DOI: 10.1158/1940-6207.CAPR-11-0528
Fan, W., Downes, M., Atkins, A., Yu, R., Evans, R.M. Nuclear receptors and AMPK: resetting metabolism. (2011) Cold Spring Harbor Symposia on Quantitative Biology. 76:17-22. DOI: 10.1101/sqb.2012.76.010470
Lamia, K.A., Papp, S.J., Yu, R.T., Barish, G.D., Uhlenhaut, N.H., Jonker, J.W., Downes, M., Evans, R.M. Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. (2011) Nature. 480(7378):552-6. DOI: 10.1038/nature10700
Krebs, P., Fan, W., Chen, Y.H., Tobita, K., Downes, M.R., Wood, M.R., Sun, L., Li, X., Xia, Y., Ding, N., Spaeth, J.M., Moresco, E.M., Boyer, T.G., Lo, C.W., Yen, J., Evans, R.M., Beutler, B. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. (2011) Proceedings of the National Academy of Sciences of the United States of America. 108(49):19678-82. DOI: 10.1073/pnas.1117835108
Yamamoto, H., Williams, E.G., Mouchiroud, L., Cantó, C., Fan, W., Downes, M., Héligon, C., Barish, G.D., Desvergne, B., Evans, R.M., Schoonjans, K., Auwerx, J. NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. (2011) Cell. 147(4):827-39. DOI: 10.1016/j.cell.2011.10.017
Pei, L., Leblanc, M., Barish, G., Atkins, A., Nofsinger, R., Whyte, J., Gold, D., He, M., Kawamura, K., Li, H.R., Downes, M., Yu, R.T., Powell, H.C., Lingrel, J.B., Evans, R.M. Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. (2011) Nature Medicine. 17(11):1466-72. DOI: 10.1038/nm.2450
Murphy, S.H., Suzuki, K., Downes, M., Welch, G.L., De Jesus, P., Miraglia, L.J., Orth, A.P., Chanda, S.K., Evans, R.M., Verma, I.M. Tumor suppressor protein (p)53, is a regulator of NF-kappaB repression by the glucocorticoid receptor. (2011) Proceedings of the National Academy of Sciences of the United States of America. 108(41):17117-22. DOI: 10.1073/pnas.1114420108
Sugii, S., Evans, R.M. Epigenetic codes of PPARγ in metabolic disease. (2011) FEBS Lett. 585(13):2121-8. DOI: 10.1016/j.febslet.2011.05.007
Mihaylova, M.M., Vasquez, D.S., Ravnskjaer, K., Denechaud, P.D., Yu, R.T., Alvarez, J.G., Downes, M., Evans, R.M., Montminy, M., Shaw, R.J. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. (2011) Cell. 145(4):607-21. DOI: 10.1016/j.cell.2011.03.043
Kacevska, M., Downes, M.R., Sharma, R., Evans, R.M., Clarke, S.J., Liddle, C., Robertson, G.R. Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism. (2011) Clinical Cancer Research. 17(10):3170-80. DOI: 10.1158/1078-0432.CCR-10-3289
Sugii, S., Kida, Y., Berggren, W.T., Evans, R.M. Feeder-dependent and feeder-independent iPS cell derivation from human and mouse adipose stem cells. (2011) Nature Protocols. 6(3):346-58. DOI: 10.1038/nprot.2010.199
Narkar, V.A., Fan, W., Downes, M., Yu, R.T., Jonker, J.W., Alaynick, W.A., Banayo, E., Karunasiri, M.S., Lorca, S., Evans, R.M. Exercise and PGC-1α-independent synchronization of type I muscle metabolism and vasculature by ERRγ. (2011) Cell Metabolism. 13(3):283-93. DOI: 10.1016/j.cmet.2011.01.019
Lister, R., Pelizzola, M., Kida, Y.S., Hawkins, R.D., Nery, J.R., Hon, G., Antosiewicz-Bourget, J., O'Malley, R., Castanon, R., Klugman, S., Downes, M., Yu, R., Stewart, R., Ren, B., Thomson, J.A., Evans, R.M., Ecker, J.R. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. (2011) Nature. 471(7336):68-73. DOI: 10.1038/nature09798
Diehl, C.J., Barish, G.D., Downes, M., Chou, M.Y., Heinz, S., Glass, C.K., Evans, R.M., Witztum, J.L. Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells. (2011) Molecular Endocrinology. 25(3):529-45. DOI: 10.1210/me.2010-0384
Berry, R., Harewood, L., Pei, L., Fisher, M., Brownstein, D., Ross, A., Alaynick, W.A., Moss, J., Hastie, N.D., Hohenstein, P., Davies, J.A., Evans, R.M., FitzPatrick, D.R. Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla. (2011) Human Molecular Genetics. 20(5):917-26. DOI: 10.1093/hmg/ddq530
Fang, S., Suh, J.M., Atkins, A.R., Hong, S.H., Leblanc, M., Nofsinger, R.R., Yu, R.T., Downes, M., Evans, R.M. Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance. (2011) Proceedings of the National Academy of Sciences of the United States of America. 108(8):3412-7. DOI: 10.1073/pnas.1017707108
Barish, G.D., Yu, R.T., Karunasiri, M., Ocampo, C.B., Dixon, J., Benner, C., Dent, A.L., Tangirala, R.K., Evans, R.M. Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response. (2010) Genes & Development. 24(24):2760-5. DOI: 10.1101/gad.1998010
Reilly, S.M., Bhargava, P., Liu, S., Gangl, M.R., Gorgun, C., Nofsinger, R.R., Evans, R.M., Qi, L., Hu, F.B., Lee, C.H. Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. (2010) Cell Metabolism. 12(6):643-53. DOI: 10.1016/j.cmet.2010.11.007
Szanto, A., Balint, B.L., Nagy, Z.S., Barta, E., Dezso, B., Pap, A., Szeles, L., Poliska, S., Oros, M., Evans, R.M., Barak, Y., Schwabe, J., Nagy, L. STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells. (2010) Immunity. 33(5):699-712. DOI: 10.1016/j.immuni.2010.11.009
Lamia, K.A., Evans, R.M. Metabolism: Tick, tock, a beta-cell clock. (2010) Nature. 466(7306):571-2. DOI: 10.1038/466571a
Wei, W., Wang, X., Yang, M., Smith, L.C., Dechow, P.C., Sonoda, J., Evans, R.M., Wan, Y. PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss. (2010) Cell Metabolism. 11(6):503-16. DOI: 10.1016/j.cmet.2010.04.015
Shaw, R.J., Evans, R.M., Simon, M.C. Metabolism and cancer in La Jolla. (2010) Cancer Research. 70(10):3864-9. DOI: 10.1158/0008-5472.CAN-09-4529
Sugii, S., Kida, Y., Kawamura, T., Suzuki, J., Vassena, R., Yin, Y.Q., Lutz, M.K., Berggren, W.T., Izpisúa Belmonte, J.C., Evans, R.M. Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(8):3558-63. DOI: 10.1073/pnas.0910172106
Alaynick, W.A., Way, J.M., Wilson, S.A., Benson, W.G., Pei, L., Downes, M., Yu, R., Jonker, J.W., Holt, J.A., Rajpal, D.K., Li, H., Stuart, J., McPherson, R., Remlinger, K.S., Chang, C.Y., McDonnell, D.P., Evans, R.M., Billin, A.N. ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. (2010) Molecular Endocrinology. 24(2):299-309. DOI: 10.1210/me.2009-0114
Wan, Y., Evans, R.M. Rosiglitazone activation of PPARgamma suppresses fractalkine signaling. (2010) Journal of Molecular Endocrinology. 44(2):135-42. DOI: 10.1677/JME-09-0090
Jiang, Y.J., Barish, G., Lu, B., Evans, R.M., Crumrine, D., Schmuth, M., Elias, P.M., Feingold, K.R. PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation. (2010) Journal of Investigative Dermatology. 130(2):511-9. DOI: 10.1038/jid.2009.245
Qu, Q., Sun, G., Li, W., Yang, S., Ye, P., Zhao, C., Yu, R.T., Gage, F.H., Evans, R.M., Shi, Y. Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. (2010) Nature Cell Biology. 12(1):31-40; sup pp 1-9. DOI: 10.1038/ncb2001
Sugii, S., Olson, P., Sears, D.D., Saberi, M., Atkins, A.R., Barish, G.D., Hong, S.H., Castro, G.L., Yin, Y.Q., Nelson, M.C., Hsiao, G., Greaves, D.R., Downes, M., Yu, R.T., Olefsky, J.M., Evans, R.M. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106(52):22504-9. DOI: 10.1073/pnas.0912487106
Alaynick, W.A., Way, J.M., Wilson, S.A., Benson, W.G., Pei, L., Downes, M., Yu, R., Jonker, J.W., Holt, J.A., Rajpal, D.K., Li, H., Stuart, J., McPherson, R., Remlinger, K.S., Yi-Chang, C., McDonnell, D.P., Evans, R.M., Billin, A.N. ERRγ Regulates Cardiac, Gastric, and Renal Potassium Homeostasis. (2009) Endocrine Reviews. 30(7):931. DOI: 10.1210/edrv.30.7.9988
Lamia, K.A., Sachdeva, U.M., DiTacchio, L., Williams, E.C., Alvarez, J.G., Egan, D.F., Vasquez, D.S., Juguilon, H., Panda, S., Shaw, R.J., Thompson, C.B., Evans, R.M. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. (2009) Science. 326(5951):437-40. DOI: 10.1126/science.1172156
Evans, R.M. Nuclear receptors: past, present, and future. Preface. (2009) Progress in Molecular Biology and Translational Science. 87:xi-xiii. DOI: 10.1016/S1877-1173(09)87015-4
Pei, L., Evans, R.M. Retrofitting fat metabolism. (2009) Cell Metabolism. 9(6):483-4. DOI: 10.1016/j.cmet.2009.05.006
McKenna, N.J., Cooney, A.J., DeMayo, F.J., Downes, M., Glass, C.K., Lanz, R.B., Lazar, M.A., Mangelsdorf, D.J., Moore, D.D., Qin, J., Steffen, D.L., Tsai, M.J., Tsai, S.Y., Yu, R., Margolis, R.N., Evans, R.M., O'Malley, B.W. Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. (2009) Molecular Endocrinology. 23(6):740-6. DOI: 10.1210/me.2009-0135
Nofsinger, R.R., Li, P., Hong, S.H., Jonker, J.W., Barish, G.D., Ying, H., Cheng, S.Y., Leblanc, M., Xu, W., Pei, L., Kang, Y.J., Nelson, M., Downes, M., Yu, R.T., Olefsky, J.M., Lee, C.H., Evans, R.M. SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. (2008) Proceedings of the National Academy of Sciences of the United States of America. 105(50):20021-6. DOI: 10.1073/pnas.0811012105
Davies, B.S., Waki, H., Beigneux, A.P., Farber, E., Weinstein, M.M., Wilpitz, D.C., Tai, L.J., Evans, R.M., Fong, L.G., Tontonoz, P., Young, S.G. The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. (2008) Molecular Endocrinology. 22(11):2496-504. DOI: 10.1210/me.2008-0146
Kleiner, H.E., Xia, X., Sonoda, J., Zhang, J., Pontius, E., Abey, J., Evans, R.M., Moore, D.D., DiGiovanni, J. Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice. (2008) Toxicology and Applied Pharmacology. 232(2):337-50. DOI: 10.1016/j.taap.2008.07.004
Yang, C.S., Ko, S.R., Cho, B.G., Shin, D.M., Yuk, J.M., Li, S., Kim, J.M., Evans, R.M., Jung, J.S., Song, D.K., Jo, E.K. The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock. (2008) J. Cell. Mol. Med. 12(5A):1739-53. DOI: 10.1111/j.1582-4934.2007.00181.x
Narkar, V.A., Downes, M., Yu, R.T., Embler, E., Wang, Y.X., Banayo, E., Mihaylova, M.M., Nelson, M.C., Zou, Y., Juguilon, H., Kang, H., Shaw, R.J., Evans, R.M. AMPK and PPARdelta agonists are exercise mimetics. (2008) Cell. 134(3):405-15. DOI: 10.1016/j.cell.2008.06.051
Barish, G.D., Atkins, A.R., Downes, M., Olson, P., Chong, L.W., Nelson, M., Zou, Y., Hwang, H., Kang, H., Curtiss, L., Evans, R.M., Lee, C.H. PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. (2008) Proceedings of the National Academy of Sciences of the United States of America. 105(11):4271-6. DOI: 10.1073/pnas.0711875105
Downes, M., Evans, R.M. Staying the distance: avoiding the proteasomal trap. (2008) Cancer Cell. 13(3):184-5. DOI: 10.1016/j.ccr.2008.02.014
Takata, Y., Liu, J., Yin, F., Collins, A.R., Lyon, C.J., Lee, C.H., Atkins, A.R., Downes, M., Barish, G.D., Evans, R.M., Hsueh, W.A., Tangirala, R.K. PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis. (2008) Proceedings of the National Academy of Sciences of the United States of America. 105(11):4277-82. DOI: 10.1073/pnas.0708647105
Yang, X., Ongusaha, P.P., Miles, P.D., Havstad, J.C., Zhang, F., So, W.V., Kudlow, J.E., Michell, R.H., Olefsky, J.M., Field, S.J., Evans, R.M. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. (2008) Nature. 451(7181):964-9. DOI: 10.1038/nature06668
Zhang, C.L., Zou, Y., He, W., Gage, F.H., Evans, R.M. A role for adult TLX-positive neural stem cells in learning and behaviour. (2008) Nature. 451(7181):1004-7. DOI: 10.1038/nature06562
Man, M.Q., Barish, G.D., Schmuth, M., Crumrine, D., Barak, Y., Chang, S., Jiang, Y., Evans, R.M., Elias, P.M., Feingold, K.R. Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation. (2008) Journal of Investigative Dermatology. 128(2):370-7. DOI: 10.1038/sj.jid.5701026
Sonoda, J., Pei, L., Evans, R.M. Nuclear receptors: decoding metabolic disease. (2008) FEBS Lett. 582(1):2-9. DOI: 10.1016/j.febslet.2007.11.016
Wan, Y., Chong, L.W., Evans, R.M. PPAR-gamma regulates osteoclastogenesis in mice. (2007) Nature Medicine. 13(12):1496-503. DOI: 10.1038/nm1672
Ding, G., Fu, M., Qin, Q., Lewis, W., Kim, H.W., Fukai, T., Bacanamwo, M., Chen, Y.E., Schneider, M.D., Mangelsdorf, D.J., Evans, R.M., Yang, Q. Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage. (2007) Cardiovascular Research. 76(2):269-79. DOI: 10.1016/j.cardiores.2007.06.027
Sun, G., Yu, R.T., Evans, R.M., Shi, Y. Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(39):15282-7. DOI: 10.1073/pnas.0704089104
Sonoda, J., Laganière, J., Mehl, I.R., Barish, G.D., Chong, L.W., Li, X., Scheffler, I.E., Mock, D.C., Bataille, A.R., Robert, F., Lee, C.H., Giguère, V., Evans, R.M. Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. (2007) Genes & Development. 21(15):1909-20. DOI: 10.1101/gad.1553007
Wan, Y., Saghatelian, A., Chong, L.W., Zhang, C.L., Cravatt, B.F., Evans, R.M. Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. (2007) Genes & Development. 21(15):1895-908. DOI: 10.1101/gad.1567207
Alaynick, W.A., Kondo, R.P., Xie, W., He, W., Dufour, C.R., Downes, M., Jonker, J.W., Giles, W., Naviaux, R.K., Giguère, V., Evans, R.M. ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart. (2007) Cell Metabolism. 6(1):13-24. DOI: 10.1016/j.cmet.2007.06.007
Yang, X., Lamia, K.A., Evans, R.M. Nuclear receptors, metabolism, and the circadian clock. (2007) Cold Spring Harbor Symposia on Quantitative Biology. 72:387-94. DOI: 10.1101/sqb.2007.72.058
Dufour, C.R., Wilson, B.J., Huss, J.M., Kelly, D.P., Alaynick, W.A., Downes, M., Evans, R.M., Blanchette, M., Giguère, V. Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. (2007) Cell Metabolism. 5(5):345-56. DOI: 10.1016/j.cmet.2007.03.007
Sonoda, J., Mehl, I.R., Chong, L.W., Nofsinger, R.R., Evans, R.M. PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(12):5223-8. DOI: 10.1073/pnas.0611623104
Yoh, S.M., Cho, H., Pickle, L., Evans, R.M., Jones, K.A. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. (2007) Genes & Development. 21(2):160-74. DOI: 10.1101/gad.1503107
Germain, P., Chambon, P., Eichele, G., Evans, R.M., Lazar, M.A., Leid, M., De Lera, A.R., Lotan, R., Mangelsdorf, D.J., Gronemeyer, H. International Union of Pharmacology. LXIII. Retinoid X receptors. (2006) Pharmacol. Rev. 58(4):760-72. DOI: 10.1124/pr.58.4.7
Germain, P., Chambon, P., Eichele, G., Evans, R.M., Lazar, M.A., Leid, M., De Lera, A.R., Lotan, R., Mangelsdorf, D.J., Gronemeyer, H. International Union of Pharmacology. LX. Retinoic acid receptors. (2006) Pharmacol. Rev. 58(4):712-25. DOI: 10.1124/pr.58.4.4
Kharroubi, I., Lee, C.H., Hekerman, P., Darville, M.I., Evans, R.M., Eizirik, D.L., Cnop, M. BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells. (2006) Diabetologia. 49(10):2350-8. DOI: 10.1007/s00125-006-0366-5
Yang, X., Downes, M., Yu, R.T., Bookout, A.L., He, W., Straume, M., Mangelsdorf, D.J., Evans, R.M. Nuclear receptor expression links the circadian clock to metabolism. (2006) Cell. 126(4):801-10. DOI: 10.1016/j.cell.2006.06.050
Bookout, A.L., Jeong, Y., Downes, M., Yu, R.T., Evans, R.M., Mangelsdorf, D.J. Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006) Cell. 126(4):789-99. DOI: 10.1016/j.cell.2006.06.049
Stedman, C., Liddle, C., Coulter, S., Sonoda, J., Alvarez, J.G., Evans, R.M., Downes, M. Benefit of farnesoid X receptor inhibition in obstructive cholestasis. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(30):11323-8. DOI: 10.1073/pnas.0604772103
Qi, L., Heredia, J.E., Altarejos, J.Y., Screaton, R., Goebel, N., Niessen, S., Macleod, I.X., Liew, C.W., Kulkarni, R.N., Bain, J., Newgard, C., Nelson, M., Evans, R.M., Yates, J., Montminy, M. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. (2006) Science. 312(5781):1763-6. DOI: 10.1126/science.1123374
Zhang, C.L., Zou, Y., Yu, R.T., Gage, F.H., Evans, R.M. Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. (2006) Genes & Development. 20(10):1308-20. DOI: 10.1101/gad.1413606
Zhou, J., Zhai, Y., Mu, Y., Gong, H., Uppal, H., Toma, D., Ren, S., Evans, R.M., Xie, W. A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. (2006) Journal of Biological Chemistry. 281(21):15013-20. DOI: 10.1074/jbc.M511116200
Barish, G.D., Narkar, V.A., Evans, R.M. PPAR delta: a dagger in the heart of the metabolic syndrome. (2006) Journal of Clinical Investigation. 116(3):590-7. DOI: 10.1172/JCI27955
Jacobs, S., Lie, D.C., DeCicco, K.L., Shi, Y., DeLuca, L.M., Gage, F.H., Evans, R.M. Retinoic acid is required early during adult neurogenesis in the dentate gyrus. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(10):3902-7. DOI: 10.1073/pnas.0511294103
Sternsdorf, T., Phan, V.T., Maunakea, M.L., Ocampo, C.B., Sohal, J., Silletto, A., Galimi, F., Le Beau, M.M., Evans, R.M., Kogan, S.C. Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia. (2006) Cancer Cell. 9(2):81-94. DOI: 10.1016/j.ccr.2005.12.030
Wang, Z., Qi, C., Krones, A., Woodring, P., Zhu, X., Reddy, J.K., Evans, R.M., Rosenfeld, M.G., Hunter, T. Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. (2006) Cell Metabolism. 3(2):111-22. DOI: 10.1016/j.cmet.2006.01.002
Lee, C.H., Olson, P., Hevener, A., Mehl, I., Chong, L.W., Olefsky, J.M., Gonzalez, F.J., Ham, J., Kang, H., Peters, J.M., Evans, R.M. PPARdelta regulates glucose metabolism and insulin sensitivity. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(9):3444-9. DOI: 10.1073/pnas.0511253103
Lee, C.H., Kang, K., Mehl, I.R., Nofsinger, R., Alaynick, W.A., Chong, L.W., Rosenfeld, J.M., Evans, R.M. Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(7):2434-9. DOI: 10.1073/pnas.0510815103
Wolf, K.K., Wood, S.G., Hunt, J.A., Walton-Strong, B.W., Yasuda, K., Lan, L., Duan, S.X., Hao, Q., Wrighton, S.A., Jeffery, E.H., Evans, R.M., Szakacs, J.G., von Moltke, L.L., Greenblatt, D.J., Court, M.H., Schuetz, E.G., Sinclair, P.R., Sinclair, J.F. Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity. (2005) Drug Metab. Dispos. 33(12):1827-36. DOI: 10.1124/dmd.105.005256
Noreault, T.L., Jacobs, J.M., Nichols, R.C., Trask, H.W., Wrighton, S.A., Sinclair, P.R., Evans, R.M., Sinclair, J.F. Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms. (2005) Toxicol. Appl. Pharmacol. 209(2):174-82. DOI: 10.1016/j.taap.2005.04.008
Barish, G.D., Downes, M., Alaynick, W.A., Yu, R.T., Ocampo, C.B., Bookout, A.L., Mangelsdorf, D.J., Evans, R.M. A Nuclear Receptor Atlas: macrophage activation. (2005) Molecular Endocrinology. 19(10):2466-77. DOI: 10.1210/me.2004-0529
Zhao, X., Sternsdorf, T., Bolger, T.A., Evans, R.M., Yao, T.P. Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. (2005) Molecular and Cellular Biology. 25(19):8456-64. DOI: 10.1128/MCB.25.19.8456-8464.2005
Margolis, R.N., Evans, R.M., O'Malley, B.W. The Nuclear Receptor Signaling Atlas: development of a functional atlas of nuclear receptors. (2005) Molecular Endocrinology. 19(10):2433-6. DOI: 10.1210/me.2004-0461
Fu, M., Sun, T., Bookout, A.L., Downes, M., Yu, R.T., Evans, R.M., Mangelsdorf, D.J. A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. (2005) Molecular Endocrinology. 19(10):2437-50. DOI: 10.1210/me.2004-0539
Noreault, T.L., Kostrubsky, V.E., Wood, S.G., Nichols, R.C., Strom, S.C., Trask, H.W., Wrighton, S.A., Evans, R.M., Jacobs, J.M., Sinclair, P.R., Sinclair, J.F. Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes. (2005) Drug Metab. Dispos. 33(7):993-1003. DOI: 10.1124/dmd.105.003954
Evans, R.M. The nuclear receptor superfamily: a rosetta stone for physiology. (2005) Molecular Endocrinology. 19(6):1429-38. DOI: 10.1210/me.2005-0046
Pavri, R., Lewis, B., Kim, T.K., Dilworth, F.J., Erdjument-Bromage, H., Tempst, P., de Murcia, G., Evans, R., Chambon, P., Reinberg, D. PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. (2005) Molecular Cell. 18(1):83-96. DOI: 10.1016/j.molcel.2005.02.034
Sonoda, J., Chong, L.W., Downes, M., Barish, G.D., Coulter, S., Liddle, C., Lee, C.H., Evans, R.M. Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(6):2198-203. DOI: 10.1073/pnas.0409481102
Stedman, C.A., Liddle, C., Coulter, S.A., Sonoda, J., Alvarez, J.G., Moore, D.D., Evans, R.M., Downes, M. Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(6):2063-8. DOI: 10.1073/pnas.0409794102
Galimi, F., Saez, E., Gall, J., Hoong, N., Cho, G., Evans, R.M., Verma, I.M. Development of ecdysone-regulated lentiviral vectors. (2005) Mol. Ther. 11(1):142-8. DOI: 10.1016/j.ymthe.2004.08.021
Shalom-Barak, T., Nicholas, J.M., Wang, Y., Zhang, X., Ong, E.S., Young, T.H., Gendler, S.J., Evans, R.M., Barak, Y. Peroxisome proliferator-activated receptor gamma controls Muc1 transcription in trophoblasts. (2004) Molecular and Cellular Biology. 24(24):10661-9. DOI: 10.1128/MCB.24.24.10661-10669.2004
Cheng, L., Ding, G., Qin, Q., Huang, Y., Lewis, W., He, N., Evans, R.M., Schneider, M.D., Brako, F.A., Xiao, Y., Chen, Y.E., Yang, Q. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. (2004) Nature Medicine. 10(11):1245-50. DOI: 10.1038/nm1116
Zhang, J., Huang, W., Qatanani, M., Evans, R.M., Moore, D.D. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. (2004) Journal of Biological Chemistry. 279(47):49517-22. DOI: 10.1074/jbc.M409041200
Barish, G.D., Evans, R.M. A nuclear strike against Listeria--the evolving life of LXR. (2004) Cell. 119(2):149-51. DOI: 10.1016/j.cell.2004.10.003
Evans, R. A transcriptional basis for physiology. (2004) Nature Medicine. 10(10):1022-6. DOI: 10.1038/nm1004-1022
Wang, Y.X., Zhang, C.L., Yu, R.T., Cho, H.K., Nelson, M.C., Bayuga-Ocampo, C.R., Ham, J., Kang, H., Evans, R.M. Regulation of muscle fiber type and running endurance by PPARdelta. (2004) PLOS Biology. 2(10):e294. DOI: 10.1371/journal.pbio.0020294
Evans, R.M. 2003 Keio Medical Science Prize commemorative lecture. PPARs and the complex journey to obesity. (2004) Keio J Med. 53(2):53-8.
Barish, G.D., Evans, R.M. PPARs and LXRs: atherosclerosis goes nuclear. (2004) Trends in Endocrinology and Metabolism. 15(4):158-65. DOI: 10.1016/j.tem.2004.03.003
Koo, S.H., Satoh, H., Herzig, S., Lee, C.H., Hedrick, S., Kulkarni, R., Evans, R.M., Olefsky, J., Montminy, M. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. (2004) Nature Medicine. 10(5):530-4. DOI: 10.1038/nm1044
Assem, M., Schuetz, E.G., Leggas, M., Sun, D., Yasuda, K., Reid, G., Zelcer, N., Adachi, M., Strom, S., Evans, R.M., Moore, D.D., Borst, P., Schuetz, J.D. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. (2004) Journal of Biological Chemistry. 279(21):22250-7. DOI: 10.1074/jbc.M314111200
Evans, R.M., Barish, G.D., Wang, Y.X. PPARs and the complex journey to obesity. (2004) Nature Medicine. 10(4):355-61. DOI: 10.1038/nm1025
Saez, E., Rosenfeld, J., Livolsi, A., Olson, P., Lombardo, E., Nelson, M., Banayo, E., Cardiff, R.D., Izpisua-Belmonte, J.C., Evans, R.M. PPAR gamma signaling exacerbates mammary gland tumor development. (2004) Genes & Development. 18(5):528-40. DOI: 10.1101/gad.1167804
Tsai, C.C., Kao, H.Y., Mitzutani, A., Banayo, E., Rajan, H., McKeown, M., Evans, R.M. Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(12):4047-52. DOI: 10.1073/pnas.0400615101
Saini, S.P., Sonoda, J., Xu, L., Toma, D., Uppal, H., Mu, Y., Ren, S., Moore, D.D., Evans, R.M., Xie, W. A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. (2004) Molecular Pharmacology. 65(2):292-300. DOI: 10.1124/mol.65.2.292
Xu, W., Cho, H., Kadam, S., Banayo, E.M., Anderson, S., Yates, J.R., Emerson, B.M., Evans, R.M. A methylation-mediator complex in hormone signaling. (2004) Genes & Development. 18(2):144-56. DOI: 10.1101/gad.1141704
Shi, Y., Chichung Lie, D., Taupin, P., Nakashima, K., Ray, J., Yu, R.T., Gage, F.H., Evans, R.M. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. (2004) Nature. 427(6969):78-83. DOI: 10.1038/nature02211
Demarest, S.J., Deechongkit, S., Dyson, H.J., Evans, R.M., Wright, P.E. Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein. (2004) Protein Sci. 13(1):203-10. DOI: 10.1110/ps.03366504
Evans, R.M. An interview with Ronald M. Evans, Ph.D. Investigator, the Salk Institute for Biological Studies. (2003) Assay Drug Dev Technol. 1(6):749-54. DOI: 10.1089/154065803772613381
He, W., Barak, Y., Hevener, A., Olson, P., Liao, D., Le, J., Nelson, M., Ong, E., Olefsky, J.M., Evans, R.M. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. (2003) Proceedings of the National Academy of Sciences of the United States of America. 100(26):15712-7. DOI: 10.1073/pnas.2536828100
Natarajan, C., Muthian, G., Barak, Y., Evans, R.M., Bright, J.J. Peroxisome proliferator-activated receptor-gamma-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis. (2003) Journal of Immunology. 171(11):5743-50.
Hevener, A.L., He, W., Barak, Y., Le, J., Bandyopadhyay, G., Olson, P., Wilkes, J., Evans, R.M., Olefsky, J. Muscle-specific Pparg deletion causes insulin resistance. (2003) Nature Medicine. 9(12):1491-7. DOI: 10.1038/nm956
Lee, C.H., Chawla, A., Urbiztondo, N., Liao, D., Boisvert, W.A., Evans, R.M., Curtiss, L.K. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. (2003) Science. 302(5644):453-7. DOI: 10.1126/science.1087344
Saez, E., Olson, P., Evans, R.M. Genetic deficiency in Pparg does not alter development of experimental prostate cancer. (2003) Nature Medicine. 9(10):1265-6. DOI: 10.1038/nm928
Rosenfeld, J.M., Vargas, R., Xie, W., Evans, R.M. Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. (2003) Molecular Endocrinology. 17(7):1268-82. DOI: 10.1210/me.2002-0421
Xu, W., Cho, H., Evans, R.M. Acetylation and methylation in nuclear receptor gene activation. (2003) Meth. Enzymol. 364:205-23.
Lee, C.H., Olson, P., Evans, R.M. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. (2003) Endocrinology. 144(6):2201-7. DOI: 10.1210/en.2003-0288
Wang, Y.X., Lee, C.H., Tiep, S., Yu, R.T., Ham, J., Kang, H., Evans, R.M. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. (2003) Cell. 113(2):159-70.
Downes, M., Verdecia, M.A., Roecker, A.J., Hughes, R., Hogenesch, J.B., Kast-Woelbern, H.R., Bowman, M.E., Ferrer, J.L., Anisfeld, A.M., Edwards, P.A., Rosenfeld, J.M., Alvarez, J.G., Noel, J.P., Nicolaou, K.C., Evans, R.M. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. (2003) Molecular Cell. 11(4):1079-92.
Gearhart, M.D., Holmbeck, S.M., Evans, R.M., Dyson, H.J., Wright, P.E. Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition. (2003) Journal of Molecular Biology. 327(4):819-32.
Xie, W., Yeuh, M.F., Radominska-Pandya, A., Saini, S.P., Negishi, Y., Bottroff, B.S., Cabrera, G.Y., Tukey, R.H., Evans, R.M. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. (2003) Proceedings of the National Academy of Sciences of the United States of America. 100(7):4150-5. DOI: 10.1073/pnas.0438010100
Nicolaou, K.C., Evans, R.M., Roecker, A.J., Hughes, R., Downes, M., Pfefferkorn, J.A. Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. (2003) Organic & Biomolecular Chemistry. 1(6):908-20.
Stenman, J., Yu, R.T., Evans, R.M., Campbell, K. Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. (2003) Development. 130(6):1113-22.
Miles, P.D., Barak, Y., Evans, R.M., Olefsky, J.M. Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. (2003) Am. J. Physiol. Endocrinol. Metab. 284(3):E618-26. DOI: 10.1152/ajpendo.00312.2002
Chawla, A., Lee, C.H., Barak, Y., He, W., Rosenfeld, J., Liao, D., Han, J., Kang, H., Evans, R.M. PPARdelta is a very low-density lipoprotein sensor in macrophages. (2003) Proceedings of the National Academy of Sciences of the United States of America. 100(3):1268-73. DOI: 10.1073/pnas.0337331100
Kao, H.Y., Han, C.C., Komar, A.A., Evans, R.M. Co-repressor release but not ligand binding is a prerequisite for transcription activation by human retinoid acid receptor alpha ligand-binding domain. (2003) Journal of Biological Chemistry. 278(9):7366-73. DOI: 10.1074/jbc.M207569200
Sonoda, J., Xie, W., Rosenfeld, J.M., Barwick, J.L., Guzelian, P.S., Evans, R.M. Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). (2002) Proceedings of the National Academy of Sciences of the United States of America. 99(21):13801-6. DOI: 10.1073/pnas.212494599
Lee, C.H., Evans, R.M. Peroxisome proliferator-activated receptor-gamma in macrophage lipid homeostasis. (2002) Trends in Endocrinology and Metabolism. 13(8):331-5.
Xie, W., Evans, R.M. Pharmaceutical use of mouse models humanized for the xenobiotic receptor. (2002) Drug Discov. Today. 7(9):509-15.
Makishima, M., Lu, T.T., Xie, W., Whitfield, G.K., Domoto, H., Evans, R.M., Haussler, M.R., Mangelsdorf, D.J. Vitamin D receptor as an intestinal bile acid sensor. (2002) Science. 296(5571):1313-6. DOI: 10.1126/science.1070477
Pitman, J.L., Tsai, C.C., Edeen, P.T., Finley, K.D., Evans, R.M., McKeown, M. DSF nuclear receptor acts as a repressor in culture and in vivo. (2002) Developmental Biology. 245(2):315-28. DOI: 10.1006/dbio.2002.0648
Shi, Y., Hon, M., Evans, R.M. The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. (2002) Proceedings of the National Academy of Sciences of the United States of America. 99(5):2613-8. DOI: 10.1073/pnas.052707099
Love, J.D., Gooch, J.T., Benko, S., Li, C., Nagy, L., Chatterjee, V.K., Evans, R.M., Schwabe, J.W. The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12. (2002) Journal of Biological Chemistry. 277(13):11385-91. DOI: 10.1074/jbc.M110869200
Tini, M., Benecke, A., Um, S.J., Torchia, J., Evans, R.M., Chambon, P. Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. (2002) Molecular Cell. 9(2):265-77.
Barak, Y., Liao, D., He, W., Ong, E.S., Nelson, M.C., Olefsky, J.M., Boland, R., Evans, R.M. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. (2002) Proceedings of the National Academy of Sciences of the United States of America. 99(1):303-8. DOI: 10.1073/pnas.012610299
Demarest, S.J., Martinez-Yamout, M., Chung, J., Chen, H., Xu, W., Dyson, H.J., Evans, R.M., Wright, P.E. Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. (2002) Nature. 415(6871):549-53. DOI: 10.1038/415549a
Kao, H.Y., Lee, C.H., Komarov, A., Han, C.C., Evans, R.M. Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. (2002) Journal of Biological Chemistry. 277(1):187-93. DOI: 10.1074/jbc.M108931200
Xu, W., Chen, H., Du, K., Asahara, H., Tini, M., Emerson, B.M., Montminy, M., Evans, R.M. A transcriptional switch mediated by cofactor methylation. (2001) Science. 294(5551):2507-11. DOI: 10.1126/science.1065961
Chawla, A., Repa, J.J., Evans, R.M., Mangelsdorf, D.J. Nuclear receptors and lipid physiology: opening the X-files. (2001) Science. 294(5548):1866-70. DOI: 10.1126/science.294.5548.1866
Lin, R.J., Sternsdorf, T., Tini, M., Evans, R.M. Transcriptional regulation in acute promyelocytic leukemia. (2001) Oncogene. 20(49):7204-15. DOI: 10.1038/sj.onc.1204853
Xie, W., Evans, R.M. Orphan nuclear receptors: the exotics of xenobiotics. (2001) Journal of Biological Chemistry. 276(41):37739-42. DOI: 10.1074/jbc.R100033200
Misner, D.L., Jacobs, S., Shimizu, Y., de Urquiza, A.M., Solomin, L., Perlmann, T., De Luca, L.M., Stevens, C.F., Evans, R.M. Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity. (2001) Proceedings of the National Academy of Sciences of the United States of America. 98(20):11714-9. DOI: 10.1073/pnas.191369798
Ordentlich, P., Downes, M., Evans, R.M. Corepressors and nuclear hormone receptor function. (2001) Current Topics in Microbiology and Immunology. 254:101-16.
Turelli, P., Doucas, V., Craig, E., Mangeat, B., Klages, N., Evans, R., Kalpana, G., Trono, D. Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication. (2001) Molecular Cell. 7(6):1245-54.
Shi, Y., Downes, M., Xie, W., Kao, H.Y., Ordentlich, P., Tsai, C.C., Hon, M., Evans, R.M. Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. (2001) Genes & Development. 15(9):1140-51. DOI: 10.1101/gad.871201
Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C.M., Nelson, M.C., Ong, E.S., Waxman, D.J., Evans, R.M. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. (2001) Proceedings of the National Academy of Sciences of the United States of America. 98(6):3375-80. DOI: 10.1073/pnas.051014398
Ghbeish, N., Tsai, C.C., Schubiger, M., Zhou, J.Y., Evans, R.M., McKeown, M. The dual role of ultraspiracle, the Drosophila retinoid X receptor, in the ecdysone response. (2001) Proceedings of the National Academy of Sciences of the United States of America. 98(7):3867-72. DOI: 10.1073/pnas.061437798
Clayton, G.M., Peak-Chew, S.Y., Evans, R.M., Schwabe, J.W. The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation. (2001) Proceedings of the National Academy of Sciences of the United States of America. 98(4):1549-54. DOI: 10.1073/pnas.041611298
Chawla, A., Boisvert, W.A., Lee, C.H., Laffitte, B.A., Barak, Y., Joseph, S.B., Liao, D., Nagy, L., Edwards, P.A., Curtiss, L.K., Evans, R.M., Tontonoz, P. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. (2001) Molecular Cell. 7(1):161-71.
Chawla, A., Barak, Y., Nagy, L., Liao, D., Tontonoz, P., Evans, R.M. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. (2001) Nature Medicine. 7(1):48-52. DOI: 10.1038/83336
Xie, W., Barwick, J.L., Simon, C.M., Pierce, A.M., Safe, S., Blumberg, B., Guzelian, P.S., Evans, R.M. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. (2000) Genes & Development. 14(23):3014-23.
Saez, E., Nelson, M.C., Eshelman, B., Banayo, E., Koder, A., Cho, G.J., Evans, R.M. Identification of ligands and coligands for the ecdysone-regulated gene switch. (2000) Proceedings of the National Academy of Sciences of the United States of America. 97(26):14512-7. DOI: 10.1073/pnas.260499497
Chawla, A., Saez, E., Evans, R.M. "Don't know much bile-ology". (2000) Cell. 103(1):1-4.
Downes, M., Ordentlich, P., Kao, H.Y., Alvarez, J.G., Evans, R.M. Identification of a nuclear domain with deacetylase activity. (2000) Proceedings of the National Academy of Sciences of the United States of America. 97(19):10330-5.
Lee, H., Shi, W., Tontonoz, P., Wang, S., Subbanagounder, G., Hedrick, C.C., Hama, S., Borromeo, C., Evans, R.M., Berliner, J.A., Nagy, L. Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. (2000) Circulation research. 87(6):516-21.
Xie, W., Barwick, J.L., Downes, M., Blumberg, B., Simon, C.M., Nelson, M.C., Neuschwander-Tetri, B.A., Brunt, E.M., Guzelian, P.S., Evans, R.M. Humanized xenobiotic response in mice expressing nuclear receptor SXR. (2000) Nature. 406(6794):435-9. DOI: 10.1038/35019116
Lin, R.J., Evans, R.M. Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers. (2000) Molecular Cell. 5(5):821-30.
Takada, I., Yu, R.T., Xu, H.E., Lambert, M.H., Montana, V.G., Kliewer, S.A., Evans, R.M., Umesono, K. Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype. (2000) Molecular Endocrinology. 14(5):733-40. DOI: 10.1210/mend.14.5.0456
Yu, R.T., Chiang, M.Y., Tanabe, T., Kobayashi, M., Yasuda, K., Evans, R.M., Umesono, K. The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision. (2000) Proceedings of the National Academy of Sciences of the United States of America. 97(6):2621-5. DOI: 10.1073/pnas.050566897
Miles, P.D., Barak, Y., He, W., Evans, R.M., Olefsky, J.M. Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. (2000) Journal of Clinical Investigation. 105(3):287-92. DOI: 10.1172/JCI8538
Kao, H.Y., Downes, M., Ordentlich, P., Evans, R.M. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. (2000) Genes & Development. 14(1):55-66.
Nagy, L., Kao, H.Y., Love, J.D., Li, C., Banayo, E., Gooch, J.T., Krishna, V., Chatterjee, K., Evans, R.M., Schwabe, J.W. Mechanism of corepressor binding and release from nuclear hormone receptors. (1999) Genes & Development. 13(24):3209-16.
Xie, W., Hong, H., Yang, N.N., Lin, R.J., Simon, C.M., Stallcup, M.R., Evans, R.M. Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2. (1999) Molecular Endocrinology. 13(12):2151-62. DOI: 10.1210/mend.13.12.0381
Asahara, H., Dutta, S., Kao, H.Y., Evans, R.M., Montminy, M. Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. (1999) Molecular and Cellular Biology. 19(12):8219-25.
Barak, Y., Nelson, M.C., Ong, E.S., Jones, Y.Z., Ruiz-Lozano, P., Chien, K.R., Koder, A., Evans, R.M. PPAR gamma is required for placental, cardiac, and adipose tissue development. (1999) Molecular Cell. 4(4):585-95.
Tsukui, T., Capdevila, J., Tamura, K., Ruiz-Lozano, P., Rodriguez-Esteban, C., Yonei-Tamura, S., Magallón, J., Chandraratna, R.A., Chien, K., Blumberg, B., Evans, R.M., Belmonte, J.C. Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(20):11376-81.
Chen, H., Lin, R.J., Xie, W., Wilpitz, D., Evans, R.M. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. (1999) Cell. 98(5):675-86.
Tsai, C.C., Kao, H.Y., Yao, T.P., McKeown, M., Evans, R.M. SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. (1999) Molecular Cell. 4(2):175-86.
Egan, D.A., Evans, R.M. Target acquisition and acute promyelocytic leukemia. (1999) Journal of Clinical Investigation. 103(10):1367-8. DOI: 10.1172/JCI7118
Lin, R.J., Egan, D.A., Evans, R.M. Molecular genetics of acute promyelocytic leukemia. (1999) Trends in Genetics. 15(5):179-84.
Ordentlich, P., Downes, M., Xie, W., Genin, A., Spinner, N.B., Evans, R.M. Unique forms of human and mouse nuclear receptor corepressor SMRT. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(6):2639-44.
Doucas, V., Tini, M., Egan, D.A., Evans, R.M. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(6):2627-32.
Chakravarti, D., Ogryzko, V., Kao, H.Y., Nash, A., Chen, H., Nakatani, Y., Evans, R.M. A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. (1999) Cell. 96(3):393-403.
Chiang, M.Y., Misner, D., Kempermann, G., Schikorski, T., Giguère, V., Sucov, H.M., Gage, F.H., Stevens, C.F., Evans, R.M. An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression. (1998) Neuron. 21(6):1353-61.
Blumberg, B., Sabbagh, W., Juguilon, H., Bolado, J., van Meter, C.M., Ong, E.S., Evans, R.M. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. (1998) Genes & Development. 12(20):3195-205.
Blumberg, B., Evans, R.M. Orphan nuclear receptors--new ligands and new possibilities. (1998) Genes & Development. 12(20):3149-55.
Dhordain, P., Lin, R.J., Quief, S., Lantoine, D., Kerckaert, J.P., Evans, R.M., Albagli, O. The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression. (1998) Nucleic Acids Research. 26(20):4645-51.
Forman, B.M., Tzameli, I., Choi, H.S., Chen, J., Simha, D., Seol, W., Evans, R.M., Moore, D.D. Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. (1998) Nature. 395(6702):612-5. DOI: 10.1038/26996
Saez, E., Tontonoz, P., Nelson, M.C., Alvarez, J.G., Ming, U.T., Baird, S.M., Thomazy, V.A., Evans, R.M. Activators of the nuclear receptor PPARgamma enhance colon polyp formation. (1998) Nature Medicine. 4(9):1058-61. DOI: 10.1038/2042
Kao, H.Y., Ordentlich, P., Koyano-Nakagawa, N., Tang, Z., Downes, M., Kintner, C.R., Evans, R.M., Kadesch, T. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. (1998) Genes & Development. 12(15):2269-77.
Ryan, A.K., Blumberg, B., Rodriguez-Esteban, C., Yonei-Tamura, S., Tamura, K., Tsukui, T., de la Peña, J., Sabbagh, W., Greenwald, J., Choe, S., Norris, D.P., Robertson, E.J., Evans, R.M., Rosenfeld, M.G., Izpisúa Belmonte, J.C. Pitx2 determines left-right asymmetry of internal organs in vertebrates. (1998) Nature. 394(6693):545-51. DOI: 10.1038/29004
Lin, R.J., Kao, H.Y., Ordentlich, P., Evans, R.M. The transcriptional basis of steroid physiology. (1998) Cold Spring Harbor Symposia on Quantitative Biology. 63:577-85.
Blanco, J.C., Minucci, S., Lu, J., Yang, X.J., Walker, K.K., Chen, H., Evans, R.M., Nakatani, Y., Ozato, K. The histone acetylase PCAF is a nuclear receptor coactivator. (1998) Genes & Development. 12(11):1638-51.
Blumberg, B., Kang, H., Bolado, J., Chen, H., Craig, A.G., Moreno, T.A., Umesono, K., Perlmann, T., De Robertis, E.M., Evans, R.M. BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. (1998) Genes & Development. 12(9):1269-77.
LaMorte, V.J., Dyck, J.A., Ochs, R.L., Evans, R.M. Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body. (1998) Proceedings of the National Academy of Sciences of the United States of America. 95(9):4991-6.
Tontonoz, P., Nagy, L., Alvarez, J.G., Thomazy, V.A., Evans, R.M. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. (1998) Cell. 93(2):241-52.
Nagy, L., Tontonoz, P., Alvarez, J.G., Chen, H., Evans, R.M. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. (1998) Cell. 93(2):229-40.
Lin, R.J., Nagy, L., Inoue, S., Shao, W., Miller, W.H., Evans, R.M. Role of the histone deacetylase complex in acute promyelocytic leukaemia. (1998) Nature. 391(6669):811-4. DOI: 10.1038/35895
Ruiz-Lozano, P., Smith, S.M., Perkins, G., Kubalak, S.W., Boss, G.R., Sucov, H.M., Evans, R.M., Chien, K.R. Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos. (1998) Development. 125(3):533-44.
Saez, E., No, D., West, A., Evans, R.M. Inducible gene expression in mammalian cells and transgenic mice. (1997) Curr. Opin. Biotechnol. 8(5):608-16.
Li, C., Evans, R.M. Ligation independent cloning irrespective of restriction site compatibility. (1997) Nucleic Acids Research. 25(20):4165-6.
Forman, B.M., Ruan, B., Chen, J., Schroepfer, G.J., Evans, R.M. The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94(20):10588-93.
Dhordain, P., Albagli, O., Lin, R.J., Ansieau, S., Quief, S., Leutz, A., Kerckaert, J.P., Evans, R.M., Leprince, D. Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94(20):10762-7.
Chen, H., Lin, R.J., Schiltz, R.L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M.L., Nakatani, Y., Evans, R.M. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. (1997) Cell. 90(3):569-80.
Perlmann, T., Evans, R.M. Nuclear receptors in Sicily: all in the famiglia. (1997) Cell. 90(3):391-7.
Zelhof, A.C., Ghbeish, N., Tsai, C., Evans, R.M., McKeown, M. A role for ultraspiracle, the Drosophila RXR, in morphogenetic furrow movement and photoreceptor cluster formation. (1997) Development. 124(13):2499-506.
Sem, D.S., Casimiro, D.R., Kliewer, S.A., Provencal, J., Evans, R.M., Wright, P.E. NMR spectroscopic studies of the DNA-binding domain of the monomer-binding nuclear orphan receptor, human estrogen related receptor-2. The carboxyl-terminal extension to the zinc-finger region is unst (1997) Journal of Biological Chemistry. 272(29):18038-43.
Lee, R.Y., Luo, J., Evans, R.M., Giguere, V., Sucov, H.M. Compartment-selective sensitivity of cardiovascular morphogenesis to combinations of retinoic acid receptor gene mutations. (1997) Circulation research. 80(6):757-764.
Nagy, L., Kao, H.Y., Chakravarti, D., Lin, R.J., Hassig, C.A., Ayer, D.E., Schreiber, S.L., Evans, R.M. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. (1997) Cell. 89(3):373-80.
Forman, B.M., Chen, J., Evans, R.M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94(9):4312-7.
Schulman, I.G., Evans, R.M. Retinoid receptors in development and disease. (1997) Leukemia. 11 Suppl 3:376-7.
Li, C., Schwabe, J.W., Banayo, E., Evans, R.M. Coexpression of nuclear receptor partners increases their solubility and biological activities. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94(6):2278-83.
Schulman, I.G., Li, C., Schwabe, J.W., Evans, R.M. The phantom ligand effect: allosteric control of transcription by the retinoid X receptor. (1997) Genes & Development. 11(3):299-308.
Blumberg, B., Bolado, J., Moreno, T.A., Kintner, C., Evans, R.M., Papalopulu, N. An essential role for retinoid signaling in anteroposterior neural patterning. (1997) Development. 124(2):373-9.
Tontonoz, P., Singer, S., Forman, B.M., Sarraf, P., Fletcher, J.A., Fletcher, C.D., Brun, R.P., Mueller, E., Altiok, S., Oppenheim, H., Evans, R.M., Spiegelman, B.M. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94(1):237-41.
Süsens, U., Aguiluz, J.B., Evans, R.M., Borgmeyer, U. The germ cell nuclear factor mGCNF is expressed in the developing nervous system. (1997) Developmental Neuroscience. 19(5):410-20.
Forman, B.M., Chen, J., Evans, R.M. The peroxisome proliferator-activated receptors: ligands and activators. (1996) Ann. N. Y. Acad. Sci. 804:266-75.
Doucas, V., Evans, R.M. The PML nuclear compartment and cancer. (1996) Biochimica et Biophysica Acta. 1288(3):M25-9.
Lala, D.S., Mukherjee, R., Schulman, I.G., Koch, S.S., Dardashti, L.J., Nadzan, A.M., Croston, G.E., Evans, R.M., Heyman, R.A. Activation of specific RXR heterodimers by an antagonist of RXR homodimers. (1996) Nature. 383(6599):450-3. DOI: 10.1038/383450a0
Chakravarti, D., LaMorte, V.J., Nelson, M.C., Nakajima, T., Schulman, I.G., Juguilon, H., Montminy, M., Evans, R.M. Role of CBP/P300 in nuclear receptor signalling. (1996) Nature. 383(6595):99-103. DOI: 10.1038/383099a0
Gruber, P.J., Kubalak, S.W., Pexieder, T., Sucov, H.M., Evans, R.M., Chien, K.R. RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. (1996) Journal of Clinical Investigation. 98(6):1332-43. DOI: 10.1172/JCI118920
Perlmann, T., Umesono, K., Rangarajan, P.N., Forman, B.M., Evans, R.M. Two distinct dimerization interfaces differentially modulate target gene specificity of nuclear hormone receptors. (1996) Molecular Endocrinology. 10(8):958-66. DOI: 10.1210/mend.10.8.8843412
Chen, J.D., Umesono, K., Evans, R.M. SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers. (1996) Proceedings of the National Academy of Sciences of the United States of America. 93(15):7567-71.
Schulman, I.G., Juguilon, H., Evans, R.M. Activation and repression by nuclear hormone receptors: hormone modulates an equilibrium between active and repressive states. (1996) Molecular and Cellular Biology. 16(7):3807-13.
Early, E., Moore, M.A., Kakizuka, A., Nason-Burchenal, K., Martin, P., Evans, R.M., Dmitrovsky, E. Transgenic expression of PML/RARalpha impairs myelopoiesis. (1996) Proceedings of the National Academy of Sciences of the United States of America. 93(15):7900-4.
Blumberg, B., Bolado, J., Derguini, F., Craig, A.G., Moreno, T.A., Chakravarti, D., Heyman, R.A., Buck, J., Evans, R.M. Novel retinoic acid receptor ligands in Xenopus embryos. (1996) Proceedings of the National Academy of Sciences of the United States of America. 93(10):4873-8.
Achkar, C.C., Derguini, F., Blumberg, B., Langston, A., Levin, A.A., Speck, J., Evans, R.M., Bolado, J., Nakanishi, K., Buck, J., Gudas, L.J. 4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors. (1996) Proceedings of the National Academy of Sciences of the United States of America. 93(10):4879-84.
No, D., Yao, T.P., Evans, R.M. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. (1996) Proceedings of the National Academy of Sciences of the United States of America. 93(8):3346-51.
Brun, R.P., Tontonoz, P., Forman, B.M., Ellis, R., Chen, J., Evans, R.M., Spiegelman, B.M. Differential activation of adipogenesis by multiple PPAR isoforms. (1996) Genes & Development. 10(8):974-84.
Göttlicher, M., Heck, S., Doucas, V., Wade, E., Kullmann, M., Cato, A.C., Evans, R.M., Herrlich, P. Interaction of the Ubc9 human homologue with c-Jun and with the glucocorticoid receptor. (1996) Steroids. 61(4):257-62.
Luo, J., Sucov, H.M., Bader, J.A., Evans, R.M., Giguère, V. Compound mutants for retinoic acid receptor (RAR) beta and RAR alpha 1 reveal developmental functions for multiple RAR beta isoforms. (1996) Mech. Dev. 55(1):33-44.
Ogura, T., Alvarez, I.S., Vogel, A., Rodríguez, C., Evans, R.M., Izpisúa Belmonte, J.C. Evidence that Shh cooperates with a retinoic acid inducible co-factor to establish ZPA-like activity. (1996) Development. 122(2):537-42.
Parker, D., Ferreri, K., Nakajima, T., LaMorte, V.J., Evans, R.M., Koerber, S.C., Hoeger, C., Montminy, M.R. Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. (1996) Molecular and Cellular Biology. 16(2):694-703.
Doucas, V., Ishov, A.M., Romo, A., Juguilon, H., Weitzman, M.D., Evans, R.M., Maul, G.G. Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure. (1996) Genes & Development. 10(2):196-207.
Sucov, H.M., Lou, J., Gruber, P.J., Kubalak, S.W., Dyson, E., Gumeringer, C.L., Lee, R.Y., Moles, S.A., Chien, K.R., Giguere, V., Evans, R.M. The molecular genetics of retinoic acid receptors: cardiovascular and limb development. (1996) Biochem. Soc. Symp. 62:143-56.
Sucov, H.M., Izpisúa-Belmonte, J.C., Gañan, Y., Evans, R.M. Mouse embryos lacking RXR alpha are resistant to retinoic-acid-induced limb defects. (1995) Development. 121(12):3997-4003.
Forman, B.M., Tontonoz, P., Chen, J., Brun, R.P., Spiegelman, B.M., Evans, R.M. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. (1995) Cell. 83(5):803-12.
Mangelsdorf, D.J., Evans, R.M. The RXR heterodimers and orphan receptors. (1995) Cell. 83(6):841-50.
Mangelsdorf, D.J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., Evans, R.M. The nuclear receptor superfamily: the second decade. (1995) Cell. 83(6):835-9.
Zelhof, A.C., Yao, T.P., Chen, J.D., Evans, R.M., McKeown, M. Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo. (1995) Molecular and Cellular Biology. 15(12):6736-45.
Stern, C.D., Yu, R.T., Kakizuka, A., Kintner, C.R., Mathews, L.S., Vale, W.W., Evans, R.M., Umesono, K. Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo. (1995) Developmental Biology. 172(1):192-205. DOI: 10.1006/dbio.1995.0015
Zelhof, A.C., Yao, T.P., Evans, R.M., McKeown, M. Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. (1995) Proceedings of the National Academy of Sciences of the United States of America. 92(23):10477-81.
Chen, J.D., Evans, R.M. A transcriptional co-repressor that interacts with nuclear hormone receptors. (1995) Nature. 377(6548):454-7. DOI: 10.1038/377454a0
Schulman, I.G., Chakravarti, D., Juguilon, H., Romo, A., Evans, R.M. Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation. (1995) Proceedings of the National Academy of Sciences of the United States of America. 92(18):8288-92.
Dyck, J.A., Warrell, R.P., Evans, R.M., Miller, W.H. Rapid diagnosis of acute promyelocytic leukemia by immunohistochemical localization of PML/RAR-alpha protein. (1995) Blood. 86(3):862-7.
Zhou, M.D., Sucov, H.M., Evans, R.M., Chien, K.R. Retinoid-dependent pathways suppress myocardial cell hypertrophy. (1995) Proceedings of the National Academy of Sciences of the United States of America. 92(16):7391-5.
Dyson, E., Sucov, H.M., Kubalak, S.W., Schmid-Schönbein, G.W., DeLano, F.A., Evans, R.M., Ross, J., Chien, K.R. Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice. (1995) Proceedings of the National Academy of Sciences of the United States of America. 92(16):7386-90.
Forman, B.M., Goode, E., Chen, J., Oro, A.E., Bradley, D.J., Perlmann, T., Noonan, D.J., Burka, L.T., McMorris, T., Lamph, W.W., Evans, R.M., Weinberger, C. Identification of a nuclear receptor that is activated by farnesol metabolites. (1995) Cell. 81(5):687-93.
Forman, B.M., Umesono, K., Chen, J., Evans, R.M. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. (1995) Cell. 81(4):541-50.
Rastinejad, F., Perlmann, T., Evans, R.M., Sigler, P.B. Structural determinants of nuclear receptor assembly on DNA direct repeats. (1995) Nature. 375(6528):203-11. DOI: 10.1038/375203a0
Sucov, H.M., Evans, R.M. Retinoic acid and retinoic acid receptors in development. (1995) Molecular Neurobiology. 10(2-3):169-84. DOI: 10.1007/BF02740674
Imakado, S., Bickenbach, J.R., Bundman, D.S., Rothnagel, J.A., Attar, P.S., Wang, X.J., Walczak, V.R., Wisniewski, S., Pote, J., Evans, R.M. Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function. (1995) Genes & Development. 9(3):317-29.
Ogura, T., Evans, R.M. Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation. (1995) Proceedings of the National Academy of Sciences of the United States of America. 92(2):392-6.
Ogura, T., Evans, R.M. A retinoic acid-triggered cascade of HOXB1 gene activation. (1995) Proceedings of the National Academy of Sciences of the United States of America. 92(2):387-91.
Kotomura, N., Okada, M., Ninomiya, Y., Tsukiyama, T., Umesono, K., Evans, R.M., Niwa, O. Repression of retinoic acid-induced transactivation by embryonal LTR binding protein. (1994) J. Biochem. 116(6):1309-16.
Kitabayashi, I., Chiu, R., Umesono, K., Evans, R.M., Gachelin, G., Yokoyama, K. A novel pathway for retinoic acid-induced differentiation of F9 cells that is distinct from receptor-mediated trans-activation. (1994) In Vitro Cell. Dev. Biol. Anim. 30A(11):761-8.
Forman, B.M., Chen, J., Blumberg, B., Kliewer, S.A., Henshaw, R., Ong, E.S., Evans, R.M. Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. (1994) Molecular Endocrinology. 8(9):1253-61. DOI: 10.1210/mend.8.9.7838158
Lee, M.S., Sem, D.S., Kliewer, S.A., Provencal, J., Evans, R.M., Wright, P.E. NMR assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix. (1994) European Journal of Biochemistry. 224(2):639-50.
Yu, R.T., McKeown, M., Evans, R.M., Umesono, K. Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx. (1994) Nature. 370(6488):375-9. DOI: 10.1038/370375a0
Kliewer, S.A., Forman, B.M., Blumberg, B., Ong, E.S., Borgmeyer, U., Mangelsdorf, D.J., Umesono, K., Evans, R.M. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. (1994) Proceedings of the National Academy of Sciences of the United States of America. 91(15):7355-9.
Sucov, H.M., Dyson, E., Gumeringer, C.L., Price, J., Chien, K.R., Evans, R.M. RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. (1994) Genes & Development. 8(9):1007-18.
Almasan, A., Mangelsdorf, D.J., Ong, E.S., Wahl, G.M., Evans, R.M. Chromosomal localization of the human retinoid X receptors. (1994) Genomics. 20(3):397-403. DOI: 10.1006/geno.1994.1193
Evans, R.M. The molecular basis of signaling by vitamin A and its metabolites. (1994) Harvey Lect. 90:105-17.
Dyck, J.A., Maul, G.G., Miller, W.H., Chen, J.D., Kakizuka, A., Evans, R.M. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. (1994) Cell. 76(2):333-43.
Yao, T.P., Forman, B.M., Jiang, Z., Cherbas, L., Chen, J.D., McKeown, M., Cherbas, P., Evans, R.M. Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. (1993) Nature. 366(6454):476-9. DOI: 10.1038/366476a0
Damm, K., Evans, R.M. Identification of a domain required for oncogenic activity and transcriptional suppression by v-erbA and thyroid-hormone receptor alpha. (1993) Proceedings of the National Academy of Sciences of the United States of America. 90(22):10668-72.
Perlmann, T., Rangarajan, P.N., Umesono, K., Evans, R.M. Determinants for selective RAR and TR recognition of direct repeat HREs. (1993) Genes & Development. 7(7B):1411-22.
Lee, M.S., Kliewer, S.A., Provencal, J., Wright, P.E., Evans, R.M. Structure of the retinoid X receptor alpha DNA binding domain: a helix required for homodimeric DNA binding. (1993) Science. 260(5111):1117-21.
Damm, K., Heyman, R.A., Umesono, K., Evans, R.M. Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants. (1993) Proceedings of the National Academy of Sciences of the United States of America. 90(7):2989-93.
Rupprecht, R., Arriza, J.L., Spengler, D., Reul, J.M., Evans, R.M., Holsboer, F., Damm, K. Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor. (1993) Molecular Endocrinology. 7(4):597-603. DOI: 10.1210/mend.7.4.8388999
Li, E., Sucov, H.M., Lee, K.F., Evans, R.M., Jaenisch, R. Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene. (1993) Proceedings of the National Academy of Sciences of the United States of America. 90(4):1590-4.
Mangelsdorf, D.J., Kliewer, S.A., Kakizuka, A., Umesono, K., Evans, R.M. Retinoid receptors. (1993) Recent Prog. Horm. Res. 48:99-121.
Tsai, S., Bartelmez, S., Heyman, R., Damm, K., Evans, M., Collins, S.J. A mutated retinoic acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line. (1992) Genes & Development. 6(12A):2258-69.
Yao, T.P., Segraves, W.A., Oro, A.E., McKeown, M., Evans, R.M. Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. (1992) Cell. 71(1):63-72.
Rangarajan, P.N., Umesono, K., Evans, R.M. Modulation of glucocorticoid receptor function by protein kinase A. (1992) Molecular Endocrinology. 6(9):1451-7. DOI: 10.1210/mend.6.9.1435789
Kliewer, S.A., Umesono, K., Noonan, D.J., Heyman, R.A., Evans, R.M. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. (1992) Nature. 358(6389):771-4. DOI: 10.1038/358771a0
Ghazal, P., DeMattei, C., Giulietti, E., Kliewer, S.A., Umesono, K., Evans, R.M. Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells. (1992) Proceedings of the National Academy of Sciences of the United States of America. 89(16):7630-4.
Cadepond, F., Gasc, J.M., Delahaye, F., Jibard, N., Schweizer-Groyer, G., Segard-Maurel, I., Evans, M., Baulieu, E.E. Hormonal regulation of the nuclear localization signals of the human glucocorticosteroid receptor. (1992) Experimental Cell Research. 201(1):99-108.
Oro, A.E., McKeown, M., Evans, R.M. The Drosophila retinoid X receptor homolog ultraspiracle functions in both female reproduction and eye morphogenesis. (1992) Development. 115(2):449-62.
Borrelli, E., Sawchenko, P.E., Evans, R.M. Pituitary hyperplasia induced by ectopic expression of nerve growth factor. (1992) Proceedings of the National Academy of Sciences of the United States of America. 89(7):2764-8.
Kakizuka, A., Sebastian, B., Borgmeyer, U., Hermans-Borgmeyer, I., Bolado, J., Hunter, T., Hoekstra, M.F., Evans, R.M. A mouse cdc25 homolog is differentially and developmentally expressed. (1992) Genes & Development. 6(4):578-90.
Miller, W.H., Kakizuka, A., Frankel, S.R., Warrell, R.P., DeBlasio, A., Levine, K., Evans, R.M., Dmitrovsky, E. Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia. (1992) Proceedings of the National Academy of Sciences of the United States of America. 89(7):2694-8.
Oro, A.E., McKeown, M., Evans, R.M. The Drosophila nuclear receptors: new insight into the actions of nuclear receptors in development. (1992) Current Opinion in Genetics & Development. 2(2):269-74.
Mangelsdorf, D.J., Borgmeyer, U., Heyman, R.A., Zhou, J.Y., Ong, E.S., Oro, A.E., Kakizuka, A., Evans, R.M. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. (1992) Genes & Development. 6(3):329-44.
Blumberg, B., Mangelsdorf, D.J., Dyck, J.A., Bittner, D.A., Evans, R.M., De Robertis, E.M. Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg. (1992) Proceedings of the National Academy of Sciences of the United States of America. 89(6):2321-5.
Kliewer, S.A., Umesono, K., Heyman, R.A., Mangelsdorf, D.J., Dyck, J.A., Evans, R.M. Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. (1992) Proceedings of the National Academy of Sciences of the United States of America. 89(4):1448-52.
Kliewer, S.A., Umesono, K., Mangelsdorf, D.J., Evans, R.M. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. (1992) Nature. 355(6359):446-9. DOI: 10.1038/355446a0
Heyman, R.A., Mangelsdorf, D.J., Dyck, J.A., Stein, R.B., Eichele, G., Evans, R.M., Thaller, C. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. (1992) Cell. 68(2):397-406.
Kitabayashi, I., Kawakami, Z., Chiu, R., Ozawa, K., Matsuoka, T., Toyoshima, S., Umesono, K., Evans, R.M., Gachelin, G., Yokoyama, K. Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells. (1992) EMBO Journal. 11(1):167-75.
Schüle, R., Evans, R.M. Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper. (1991) Trends in Genetics. 7(11-12):377-81.
Kakizuka, A., Miller, W.H., Umesono, K., Warrell, R.P., Frankel, S.R., Murty, V.V., Dmitrovsky, E., Evans, R.M. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. (1991) Cell. 66(4):663-74.
Mangelsdorf, D.J., Umesono, K., Kliewer, S.A., Borgmeyer, U., Ong, E.S., Evans, R.M. A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. (1991) Cell. 66(3):555-61.
Schüle, R., Rangarajan, P., Yang, N., Kliewer, S., Ransone, L.J., Bolado, J., Verma, I.M., Evans, R.M. Retinoic acid is a negative regulator of AP-1-responsive genes. (1991) Proceedings of the National Academy of Sciences of the United States of America. 88(14):6092-6.
Umesono, K., Murakami, K.K., Thompson, C.C., Evans, R.M. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. (1991) Cell. 65(7):1255-66.
Yang, N., Schüle, R., Mangelsdorf, D.J., Evans, R.M. Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor. (1991) Proceedings of the National Academy of Sciences of the United States of America. 88(9):3559-63.
Cadepond, F., Schweizer-Groyer, G., Segard-Maurel, I., Jibard, N., Hollenberg, S.M., Giguère, V., Evans, R.M., Baulieu, E.E. Heat shock protein 90 as a critical factor in maintaining glucocorticosteroid receptor in a nonfunctional state. (1991) Journal of Biological Chemistry. 266(9):5834-41.
Schüle, R., Evans, R.M. Functional antagonism between oncoprotein c-Jun and steroid hormone receptors. (1991) Cold Spring Harbor Symposia on Quantitative Biology. 56:119-27. DOI: 10.1101/SQB.1991.056.01.016
Schüle, R., Rangarajan, P., Kliewer, S., Ransone, L.J., Bolado, J., Yang, N., Verma, I.M., Evans, R.M. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. (1990) Cell. 62(6):1217-26.
Oro, A.E., McKeown, M., Evans, R.M. Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor. (1990) Nature. 347(6290):298-301. DOI: 10.1038/347298a0
Sucov, H.M., Murakami, K.K., Evans, R.M. Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene. (1990) Proceedings of the National Academy of Sciences of the United States of America. 87(14):5392-6.
Moolten, F.L., Wells, J.M., Heyman, R.A., Evans, R.M. Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene. (1990) Human Gene Therapy. 1(2):125-34. DOI: 10.1089/hum.1990.1.2-125
Ishikawa, T., Umesono, K., Mangelsdorf, D.J., Aburatani, H., Stanger, B.Z., Shibasaki, Y., Imawari, M., Evans, R.M., Takaku, F. A functional retinoic acid receptor encoded by the gene on human chromosome 12. (1990) Molecular Endocrinology. 4(6):837-44. DOI: 10.1210/mend-4-6-837
Mangelsdorf, D.J., Ong, E.S., Dyck, J.A., Evans, R.M. Nuclear receptor that identifies a novel retinoic acid response pathway. (1990) Nature. 345(6272):224-9. DOI: 10.1038/345224a0
Schüle, R., Umesono, K., Mangelsdorf, D.J., Bolado, J., Pike, J.W., Evans, R.M. Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene. (1990) Cell. 61(3):497-504.
Giguère, V., Evans, R.M. Identification of receptors for retinoids as members of the steroid and thyroid hormone receptor family. (1990) Meth. Enzymol. 189:223-32.
Evans, R.M. Molecular characterization of the glucocorticoid receptor. (1989) Recent Progress in Hormone Research. 45:1-22; discussion 22-7.
Umesono, K., Evans, R.M. Determinants of target gene specificity for steroid/thyroid hormone receptors. (1989) Cell. 57(7):1139-46.
Borrelli, E., Heyman, R.A., Arias, C., Sawchenko, P.E., Evans, R.M. Transgenic mice with inducible dwarfism. (1989) Nature. 339(6225):538-41. DOI: 10.1038/339538a0
Damm, K., Thompson, C.C., Evans, R.M. Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. (1989) Nature. 339(6226):593-7. DOI: 10.1038/339593a0
Thompson, C.C., Evans, R.M. Trans-activation by thyroid hormone receptors: functional parallels with steroid hormone receptors. (1989) Proceedings of the National Academy of Sciences of the United States of America. 86(10):3494-8.
Heyman, R.A., Borrelli, E., Lesley, J., Anderson, D., Richman, D.D., Baird, S.M., Hyman, R., Evans, R.M. Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency. (1989) Proceedings of the National Academy of Sciences of the United States of America. 86(8):2698-702.
Giguère, V., Ong, E.S., Evans, R.M., Tabin, C.J. Spatial and temporal expression of the retinoic acid receptor in the regenerating amphibian limb. (1989) Nature. 337(6207):566-9. DOI: 10.1038/337566a0
Evans, R.M., Arriza, J.L. A molecular framework for the actions of glucocorticoid hormones in the nervous system. (1989) Neuron. 2(2):1105-12.
Oro, A.E., Umesono, K., Evans, R.M. Steroid hormone receptor homologs in development. (1989) Development. 107 Suppl:133-40.
Evans, R.M. The v-erbA oncogene is a thyroid hormone receptor antagonist. (1989) International Journal of Cancer. 4:26-8.
Oro, A.E., Hollenberg, S.M., Evans, R.M. Transcriptional inhibition by a glucocorticoid receptor-beta-galactosidase fusion protein. (1988) Cell. 55(6):1109-14.
Hollenberg, S.M., Evans, R.M. Multiple and cooperative trans-activation domains of the human glucocorticoid receptor. (1988) Cell. 55(5):899-906.
Oro, A.E., Ong, E.S., Margolis, J.S., Posakony, J.W., McKeown, M., Evans, R.M. The Drosophila gene knirps-related is a member of the steroid-receptor gene superfamily. (1988) Nature. 336(6198):493-6. DOI: 10.1038/336493a0
Drabkin, H., Kao, F.T., Hartz, J., Hart, I., Gazdar, A., Weinberger, C., Evans, R., Gerber, M. Localization of human ERBA2 to the 3p22----3p24.1 region of chromosome 3 and variable deletion in small cell lung cancer. (1988) Proceedings of the National Academy of Sciences of the United States of America. 85(23):9258-62.
Arriza, J.L., Simerly, R.B., Swanson, L.W., Evans, R.M. The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response. (1988) Neuron. 1(9):887-900.
Umesono, K., Giguere, V., Glass, C.K., Rosenfeld, M.G., Evans, R.M. Retinoic acid and thyroid hormone induce gene expression through a common responsive element. (1988) Nature. 336(6196):262-5. DOI: 10.1038/336262a0
Borrelli, E., Heyman, R., Hsi, M., Evans, R.M. Targeting of an inducible toxic phenotype in animal cells. (1988) Proceedings of the National Academy of Sciences of the United States of America. 85(20):7572-6.
Mayo, K.E., Hammer, R.E., Swanson, L.W., Brinster, R.L., Rosenfeld, M.G., Evans, R.M. Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene. (1988) Molecular Endocrinology. 2(7):606-12. DOI: 10.1210/mend-2-7-606
Evans, R.M. The steroid and thyroid hormone receptor superfamily. (1988) Science. 240(4854):889-95.
Evans, R.M., Hollenberg, S.M. Zinc fingers: gilt by association. (1988) Cell. 52(1):1-3.
Giguère, V., Yang, N., Segui, P., Evans, R.M. Identification of a new class of steroid hormone receptors. (1988) Nature. 331(6151):91-4. DOI: 10.1038/331091a0
Evans, R.M., Hollenberg, S.M. Cooperative and positional independent trans-activation domains of the human glucocorticoid receptor. (1988) Cold Spring Harbor Symposia on Quantitative Biology. 53 Pt 2:813-8. DOI: 10.1101/SQB.1988.053.01.092
Meunier, H., Rivier, C., Evans, R.M., Vale, W. Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions. (1988) Proceedings of the National Academy of Sciences of the United States of America. 85(1):247-51.
Pratt, W.B., Jolly, D.J., Pratt, D.V., Hollenberg, S.M., Giguere, V., Cadepond, F.M., Schweizer-Groyer, G., Catelli, M.G., Evans, R.M., Baulieu, E.E. A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex. (1988) Journal of Biological Chemistry. 263(1):267-73.
Waterman, M.L., Adler, S., Nelson, C., Greene, G.L., Evans, R.M., Rosenfeld, M.G. A single domain of the estrogen receptor confers deoxyribonucleic acid binding and transcriptional activation of the rat prolactin gene. (1988) Molecular Endocrinology. 2(1):14-21. DOI: 10.1210/mend-2-1-14
Rosenfeld, M.G., Crenshaw, E.B., Lira, S.A., Swanson, L., Borrelli, E., Heyman, R., Evans, R.M. Transgenic mice: applications to the study of the nervous system. (1988) Annual Review of Neuroscience. 11:353-72. DOI: 10.1146/annurev.ne.11.030188.002033
Giguere, V., Ong, E.S., Segui, P., Evans, R.M. Identification of a receptor for the morphogen retinoic acid. (1987) Nature. 330(6149):624-9. DOI: 10.1038/330624a0
Glass, C.K., Franco, R., Weinberger, C., Albert, V.R., Evans, R.M., Rosenfeld, M.G. A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone. (1987) Nature. 329(6141):738-41. DOI: 10.1038/329738a0
Botteri, F.M., van der Putten, H., Wong, D.F., Sauvage, C.A., Evans, R.M. Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. (1987) Molecular and Cellular Biology. 7(9):3178-84.
Thompson, C.C., Weinberger, C., Lebo, R., Evans, R.M. Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system. (1987) Science. 237(4822):1610-4.
Arriza, J.L., Weinberger, C., Cerelli, G., Glaser, T.M., Handelin, B.L., Housman, D.E., Evans, R.M. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. (1987) Science. 237(4812):268-75.
Hollenberg, S.M., Giguere, V., Segui, P., Evans, R.M. Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor. (1987) Cell. 49(1):39-46.
Leff, S.E., Evans, R.M., Rosenfeld, M.G. Splice commitment dictates neuron-specific alternative RNA processing in calcitonin/CGRP gene expression. (1987) Cell. 48(3):517-24.
Weinberger, C., Giguère, V., Hollenberg, S.M., Thompson, C., Arriza, J., Evans, R.M. Human steroid receptors and erb-A gene products form a superfamily of enhancer-binding proteins. (1987) Clinical Physiology and Biochemistry. 5(3-4):179-89.
Elsholtz, H.P., Mangalam, H.J., Potter, E., Albert, V.R., Supowit, S., Evans, R.M., Rosenfeld, M.G. Two different cis-active elements transfer the transcriptional effects of both EGF and phorbol esters. (1986) Science. 234(4783):1552-7.
Weinberger, C., Thompson, C.C., Ong, E.S., Lebo, R., Gruol, D.J., Evans, R.M. The c-erb-A gene encodes a thyroid hormone receptor. (1986) Nature. 324(6098):641-6. DOI: 10.1038/324641a0
Mayo, K.E., Cerelli, G.M., Spiess, J., Rivier, J., Rosenfeld, M.G., Evans, R.M., Vale, W. Inhibin A-subunit cDNAs from porcine ovary and human placenta. (1986) Proceedings of the National Academy of Sciences of the United States of America. 83(16):5849-53.
Giguère, V., Hollenberg, S.M., Rosenfeld, M.G., Evans, R.M. Functional domains of the human glucocorticoid receptor. (1986) Cell. 46(5):645-52.
Nelson, C., Crenshaw, E.B., Franco, R., Lira, S.A., Albert, V.R., Evans, R.M., Rosenfeld, M.G. Discrete cis-active genomic sequences dictate the pituitary cell type-specific expression of rat prolactin and growth hormone genes. (1986) Nature. 322(6079):557-62. DOI: 10.1038/322557a0
Mayo, K.E., Evans, R.M., Rosenfeld, G.M. Genes encoding mammalian neuroendocrine peptides: strategies toward their identification and analysis. (1986) Annual Review of Physiology. 48:431-46. DOI: 10.1146/annurev.ph.48.030186.002243
Weinberger, C., Giguere, V., Hollenberg, S., Rosenfeld, M.G., Evans, R.M. Human steroid receptors and erbA proto-oncogene products: members of a new superfamily of enhancer binding proteins. (1986) Cold Spring Harbor Symposia on Quantitative Biology. 51 Pt 2:759-72.
Lin, C.R., Chen, W.S., Lazar, C.S., Carpenter, C.D., Gill, G.N., Evans, R.M., Rosenfeld, M.G. Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms. (1986) Cell. 44(6):839-48.
Leff, S.E., Rosenfeld, M.G., Evans, R.M. Complex transcriptional units: diversity in gene expression by alternative RNA processing. (1986) Annual Review of Biochemistry. 55:1091-117. DOI: 10.1146/annurev.bi.55.070186.005303
Hollenberg, S.M., Weinberger, C., Ong, E.S., Cerelli, G., Oro, A., Lebo, R., Thompson, E.B., Rosenfeld, M.G., Evans, R.M. Primary structure and expression of a functional human glucocorticoid receptor cDNA. (1985) Nature. 318(6047):635-41.
van der Putten, H., Botteri, F.M., Miller, A.D., Rosenfeld, M.G., Fan, H., Evans, R.M., Verma, I.M. Efficient insertion of genes into the mouse germ line via retroviral vectors. (1985) Proceedings of the National Academy of Sciences of the United States of America. 82(18):6148-52.
Murdoch, G.H., Waterman, M., Evans, R.M., Rosenfeld, M.G. Molecular mechanisms of phorbol ester, thyrotropin-releasing hormone, and growth factor stimulation of prolactin gene transcription. (1985) Journal of Biological Chemistry. 260(21):11852-8.
Amara, S.G., Arriza, J.L., Leff, S.E., Swanson, L.W., Evans, R.M., Rosenfeld, M.G. Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide. (1985) Science. 229(4718):1094-7.
Swanson, L.W., Simmons, D.M., Arriza, J., Hammer, R., Brinster, R., Rosenfeld, M.G., Evans, R.M. Novel developmental specificity in the nervous system of transgenic animals expressing growth hormone fusion genes. (1985) Nature. 317(6035):363-6.
Waterman, M., Murdoch, G.H., Evans, R.M., Rosenfeld, M.G. Cyclic AMP regulation of eukaryotic gene transcription by two discrete molecular mechanisms. (1985) Science. 229(4710):267-9.
Gill, G.N., Weber, W., Thompson, D.M., Lin, C., Evans, R.M., Rosenfeld, M.G., Gamou, S., Shimizu, N. Relationship between production of epidermal growth factor receptors, gene amplification, and chromosome 7 translocation in variant A431 cells. (1985) Somatic Cell and Molecular Genetics. 11(4):309-18.
Weinberger, C., Hollenberg, S.M., Rosenfeld, M.G., Evans, R.M. Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product. (1985) Nature. 318(6047):670-2.
Mayo, K.E., Cerelli, G.M., Rosenfeld, M.G., Evans, R.M. Characterization of cDNA and genomic clones encoding the precursor to rat hypothalamic growth hormone-releasing factor. (1985) Nature. 314(6010):464-7.
Evans, R.M., Swanson, L., Rosenfeld, M.G. Creation of transgenic animals to study development and as models for human disease. (1985) Recent Progress in Hormone Research. 41:317-37.
Barinaga, M., Bilezikjian, L.M., Vale, W.W., Rosenfeld, M.G., Evans, R.M. Hormonal regulation of gene expression: regulation of growth hormone gene transcription by growth hormone releasing factor. (1985) Oxford Surveys on Eukaryotic Genes. 2:49-73.
Weinberger, C., Hollenberg, S.M., Ong, E.S., Harmon, J.M., Brower, S.T., Cidlowski, J., Thompson, E.B., Rosenfeld, M.G., Evans, R.M. Identification of human glucocorticoid receptor complementary DNA clones by epitope selection. (1985) Science. 228(4700):740-2.
Hammer, R.E., Brinster, R.L., Rosenfeld, M.G., Evans, R.M., Mayo, K.E. Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth. (1985) Nature. 315(6018):413-6.
Jonas, V., Lin, C.R., Kawashima, E., Semon, D., Swanson, L.W., Mermod, J.J., Evans, R.M., Rosenfeld, M.G. Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression. (1985) Proceedings of the National Academy of Sciences of the United States of America. 82(7):1994-8.
Evans, R.M., Weinberger, C., Hollenberg, S., Swanson, L., Nelson, C., Rosenfeld, M.G. Inducible and developmental control of neuroendocrine genes. (1985) Cold Spring Harbor Symposia on Quantitative Biology. 50:389-97.
Sabate, M.I., Stolarsky, L.S., Polak, J.M., Bloom, S.R., Varndell, I.M., Ghatei, M.A., Evans, R.M., Rosenfeld, M.G. Regulation of neuroendocrine gene expression by alternative RNA processing. Colocalization of calcitonin and calcitonin gene-related peptide in thyroid C-cells. (1985) Journal of Biological Chemistry. 260(5):2589-92.
Barinaga, M., Bilezikjian, L.M., Vale, W.W., Rosenfeld, M.G., Evans, R.M. Independent effects of growth hormone releasing factor on growth hormone release and gene transcription. (1985) Nature. 314(6008):279-81.
Mayo, K.E., Cerelli, G.M., Lebo, R.V., Bruce, B.D., Rosenfeld, M.G., Evans, R.M. Gene encoding human growth hormone-releasing factor precursor: structure, sequence, and chromosomal assignment. (1985) Proceedings of the National Academy of Sciences of the United States of America. 82(1):63-7.
Amara, S.G., Evans, R.M., Rosenfeld, M.G. Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites. (1984) Molecular and Cellular Biology. 4(10):2151-60.
Miller, A.D., Ong, E.S., Rosenfeld, M.G., Verma, I.M., Evans, R.M. Infectious and selectable retrovirus containing an inducible rat growth hormone minigene. (1984) Science. 225(4666):993-8.
Rosenfeld, M.G., Amara, S.G., Evans, R.M. Alternative RNA processing: determining neuronal phenotype. (1984) Science. 225(4668):1315-20.
Lin, C.R., Chen, W.S., Kruiger, W., Stolarsky, L.S., Weber, W., Evans, R.M., Verma, I.M., Gill, G.N., Rosenfeld, M.G. Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells. (1984) Science. 224(4651):843-8.
Supowit, S.C., Potter, E., Evans, R.M., Rosenfeld, M.G. Polypeptide hormone regulation of gene transcription: specific 5' genomic sequences are required for epidermal growth factor and phorbol ester regulation of prolactin gene expression. (1984) Proceedings of the National Academy of Sciences of the United States of America. 81(10):2975-9.
Rosenfeld, M.G., Amara, S.G., Evans, R.M. Alternative RNA processing events as a critical developmental regulatory strategy in neuroendocrine gene expression. (1984) Biochemical Society Symposium. 49:27-44.
Murdoch, G.H., Franco, R., Evans, R.M., Rosenfeld, M.G. Polypeptide hormone regulation of gene expression. Thyrotropin-releasing hormone rapidly stimulates both transcription of the prolactin gene and the phosphorylation of a specific nuclear protein. (1983) Journal of Biological Chemistry. 258(24):15329-35.
Barinaga, M., Yamonoto, G., Rivier, C., Vale, W., Evans, R., Rosenfeld, M.G. Transcriptional regulation of growth hormone gene expression by growth hormone-releasing factor. (1983) Nature. 306(5938):84-5.
Mayo, K.E., Vale, W., Rivier, J., Rosenfeld, M.G., Evans, R.M. Expression-cloning and sequence of a cDNA encoding human growth hormone-releasing factor. (1983) Nature. 306(5938):86-8.
Fisher, L.A., Kikkawa, D.O., Rivier, J.E., Amara, S.G., Evans, R.M., Rosenfeld, M.G., Vale, W.W., Brown, M.R. Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide. (1983) Nature. 305(5934):534-6.
Rosenfeld, M.G., Mermod, J.J., Amara, S.G., Swanson, L.W., Sawchenko, P.E., Rivier, J., Vale, W.W., Evans, R.M. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. (1983) Nature. 304(5922):129-35.
Rosenfeld, M.G., Amara, S.G., Birnberg, N.C., Mermod, J.J., Murdoch, G.H., Evans, R.M. Calcitonin, prolactin, and growth hormone gene expression as model systems for the characterization of neuroendocrine regulation. (1983) Recent Progress in Hormone Research. 39:305-51.
Evans, R.M., Amara, S., Rosenfeld, M.G. Molecular events in developmental regulation of neuroendocrine genes: characterization of the novel neuropeptide CGRP. (1983) Cold Spring Harbor Symposia on Quantitative Biology. 48 Pt 1:413-7.
Palmiter, R.D., Brinster, R.L., Hammer, R.E., Trumbauer, M.E., Rosenfeld, M.G., Birnberg, N.C., Evans, R.M. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. (1982) Nature. 300(5893):611-5.
Evans, R.M., Birnberg, N.C., Rosenfeld, M.G. Glucocorticoid and thyroid hormones transcriptionally regulate growth hormone gene expression. (1982) Proceedings of the National Academy of Sciences of the United States of America. 79(24):7659-63.
Murdoch, G.H., Evans, M. Eukaryotic transcriptional regulation and chromatin-associated protein phosphorylation by cyclic AMP. (1982) Science. 218(4579):1315-7.
Murdoch, G.H., Potter, E., Nicolaisen, A.K., Evans, R.M., Rosenfeld, M.G. Epidermal growth factor rapidly stimulates prolactin gene transcription. (1982) Nature. 300(5888):192-4.
Amara, S.G., Jonas, V., Rosenfeld, M.G., Ong, E.S., Evans, R.M. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. (1982) Nature. 298(5871):240-4.
Doehmer, J., Barinaga, M., Vale, W., Rosenfeld, M.G., Verma, I.M., Evans, R.M. Introduction of rat growth hormone gene into mouse fibroblasts via a retroviral DNA vector: expression and regulation. (1982) Proceedings of the National Academy of Sciences of the United States of America. 79(7):2268-72.
Amara, S.G., Jonas, V., O'Neil, J.A., Vale, W., Rivier, J., Roos, B.A., Evans, R.M., Rosenfeld, M.G. Calcitonin COOH-terminal cleavage peptide as a model for identification of novel neuropeptides predicted by recombinant DNA analysis. (1982) J. Biol. Chem. 257(5):2129-32.
Rosenfeld, M.G., Lin, C.R., Amara, S.G., Stolarsky, L., Roos, B.A., Ong, E.S., Evans, R.M. Calcitonin mRNA polymorphism: peptide switching associated with alternative RNA splicing events. (1982) Proceedings of the National Academy of Sciences of the United States of America. 79(6):1717-21.
Evans, R.M., Amara, S.G., Rosenfeld, M.G. RNA processing regulation of neuroendorcrine gene expression. (1982) DNA. 1(4):323-8. DOI: 10.1089/dna.1982.1.323
Potter, E., Nicolaisen, A.K., Ong, E.S., Evans, R.M., Rosenfeld, M.G. Thyrotropin-releasing hormone exerts rapid nuclear effects to increase production of the primary prolactin mRNA transcript. (1981) Proceedings of the National Academy of Sciences of the United States of America. 78(11):6662-6.
Rosenfeld, M.G., Amara, S.G., Roos, B.A., Ong, E.S., Evans, R.M. Altered expression of the calcitonin gene associated with RNA polymorphism. (1981) Nature. 290(5801):63-5.
Amara, S.G., David, D.N., Rosenfeld, M.G., Roos, B.A., Evans, R.M. Characterization of rat calcitonin mRNA. (1980) Proceedings of the National Academy of Sciences of the United States of America. 77(8):4444-8.
Harpold, M.M., Evans, R.M., Salditt-Georgieff, M., Darnell, J.E. Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. (1979) Cell. 17(4):1025-35.
Soreq, H., Harpold, M., Evans, R., Darnell, J.E., Bancroft, F.C. Rat growth hormone gene: intervening sequences separate the mRNA regions. (1979) Nucleic Acids Research. 6(7):2471-82.
Ziff, E.B., Evans, R.M. Coincidence of the promoter and capped 5' terminus of RNA from the adenovirus 2 major late transcription unit. (1978) Cell. 15(4):1463-75.
Darnell, J.E., Evans, R., Fraser, N., Goldberg, S., Nevins, J., Salditt-Georgieff, M., Schwartz, H., Weber, J., Ziff, E. The definition of transcription units for mRNA. (1978) Cold Spring Harbor Symposia on Quantitative Biology. 42 Pt 1:515-22.
Evans, R.M., Fraser, N., Ziff, E., Weber, J., Wilson, M., Darnell, J.E. The initiation sites for RNA transcription in Ad2 DNA. (1977) Cell. 12(3):733-9.
Evans, R.M., Shoyab, M., Drohan, W.N., Baluda, M.A. Homogeneity and complexity of avian oncornavirus proviral DNA determined by molecular hybridization. (1977) Journal of Virology. 21(3):942-9.
Evans, R.M., Shoyab, M., Baluda, M.A. Studies on characterization of the integration sites of avian RNA tumor virus-specific DNA. (1975) Cold Spring Harbor Symposia on Quantitative Biology. 39 Pt 2:1005-7.
Evans, R.M., Baluda, M.A., Shoyab, M. Differences between the integration of avian myeloblastosis virus DNA in leukemic cells and of endogenous viral DNA in normal chicken cells. (1974) Proceedings of the National Academy of Sciences of the United States of America. 71(8):3152-6.
Shoyab, M., Evans, R.M., Baluda, M.A. Presence in leukemic cells of avian myeloblastosis virus-specific DNA sequences absent in normal chicken cells. (1974) Journal of Virology. 14(1):47-9.
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