Julie Law, PhD

Associate Professor

Plant Molecular and Cellular Biology Laboratory

Julie Law
Salk Institute for Biological Studies - Publications

all Publications


Xu, G., Law, J.A. Loops, crosstalk, and compartmentalization: it takes many layers to regulate DNA methylation. (2024) Current Opinion in Genetics & Development. 84:102147. DOI: 10.1016/j.gde.2023.102147

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Dehkordi, S.R., Wong, I.T., Ni, J., Luebeck, J., Zhu, K., Prasad, G., Krockenberger, L., Xu, G., Chowdhury, B., Rajkumar, U., Caplin, A., Muliaditan, D., Coruh, C., Jin, Q., Turner, K., Teo, S.X., Pang, A.W.C., Alexandrov, L.B., Chua, C.E.L., Furnari, F.B., Paulson, T.G., Law, J.A., Chang, H.Y., Yue, F., DasGupta, R., Zhao, J., Mischel, P.S., Bafna, V. Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change. (2023) bioRxiv. DOI: 10.1101/2023.12.12.571349

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Martins, L.M., Law, J.A. Moving targets: Mechanisms regulating siRNA production and DNA methylation during plant development. (2023) Current Opinion in Plant Biology. 75:102435. DOI: 10.1016/j.pbi.2023.102435

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Hung, K.L., Luebeck, J., Dehkordi, S.R., Colón, C.I., Li, R., Wong, I.T., Coruh, C., Dharanipragada, P., Lomeli, S.H., Weiser, N.E., Moriceau, G., Zhang, X., Bailey, C., Houlahan, K.E., Yang, W., González, R.C., Swanton, C., Curtis, C., Jamal-Hanjani, M., Henssen, A.G., Law, J.A., Greenleaf, W.J., Lo, R.S., Mischel, P.S., Bafna, V., Chang, H.Y. Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH. (2022) Nature Genetics. DOI: 10.1038/s41588-022-01190-0

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Gabrieli, T., Michaeli, Y., Avraham, S., Torchinsky, D., Margalit, S., Schütz, L., Juhasz, M., Coruh, C., Arbib, N., Zhou, Z.S., Law, J.A., Weinhold, E., Ebenstein, Y. Chemoenzymatic labeling of DNA methylation patterns for single-molecule epigenetic mapping. (2022) Nucleic Acids Research. DOI: 10.1093/nar/gkac460

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Zhou, M., Coruh, C., Xu, G., Martins, L.M., Bourbousse, C., Lambolez, A., Law, J.A. The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis. (2022) Nature Communications. 13(1):244. DOI: 10.1038/s41467-021-27690-x

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Luebeck, J., Coruh, C., Dehkordi, S.R., Lange, J.T., Turner, K.M., Deshpande, V., Pai, D.A., Zhang, C., Rajkumar, U., Law, J.A., Mischel, P.S., Bafna, V. AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications. (2020) Nature Communications. 11(1):4374. DOI: 10.1038/s41467-020-18099-z

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Wu, S., Turner, K.M., Nguyen, N., Raviram, R., Erb, M., Santini, J., Luebeck, J., Rajkumar, U., Diao, Y., Li, B., Zhang, W., Jameson, N., Corces, M.R., Granja, J.M., Chen, X., Coruh, C., Abnousi, A., Houston, J., Ye, Z., Hu, R., Yu, M., Kim, H., Law, J.A., Verhaak, R.G.W., Hu, M., Furnari, F.B., Chang, H.Y., Ren, B., Bafna, V., Mischel, P.S. Circular ecDNA promotes accessible chromatin and high oncogene expression. (2019) Nature. 575(7784):699-703. DOI: 10.1038/s41586-019-1763-5

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Argueso, C.T., Assmann, S.M., Birnbaum, K.D., Chen, S., Dinneny, J.R., Doherty, C.J., Eveland, A.L., Friesner, J., Greenlee, V.R., Law, J.A., Marshall-Colón, A., Mason, G.A., O'Lexy, R., Peck, S.C., Schmitz, R.J., Song, L., Stern, D., Varagona, M.J., Walley, J.W., Williams, C.M. Directions for research and training in plant omics: Big Questions and Big Data. (2019) Plant Direct. 3(4):e00133. DOI: 10.1002/pld3.133

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Bourbousse, C., Vegesna, N., Law, J.A. SOG1 activator and MYB3R repressors regulate a complex DNA damage network in . (2018) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1810582115

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Zhou, M., Palanca, A.M.S., Law, J.A. Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family. (2018) Nature Genetics. 50(6). DOI: 10.1038/s41588-018-0115-y

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Li, D., Palanca, A.M.S., Won, S.Y., Gao, L., Feng, Y., Vashisht, A.A., Liu, L., Zhao, Y., Liu, X., Wu, X., Li, S., Le, B., Kim, Y.J., Yang, G., Li, S., Liu, J., Wohlschlegel, J.A., Guo, H., Mo, B., Chen, X., Law, J.A. The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status. (2017) Elife. 6. DOI: 10.7554/eLife.19893

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Zhou, M., Law, J.A. RNA Pol IV and V in gene silencing: Rebel polymerases evolving away from Pol II's rules. (2015) Current Opinion in Plant Biology. 27:154-64. DOI: 10.1016/j.pbi.2015.07.005

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Law, J.A., Du, J., Hale, C.J., Feng, S., Krajewski, K., Palanca, A.M., Strahl, B.D., Patel, D.J., Jacobsen, S.E. Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. (2013) Nature. 498(7454):385-9. DOI: 10.1038/nature12178

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Zhong, X., Hale, C.J., Law, J.A., Johnson, L.M., Feng, S., Tu, A., Jacobsen, S.E. DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons. (2012) Nature Structural & Molecular Biology. 19(9):870-5. DOI: 10.1038/nsmb.2354

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Law, J.A., Vashisht, A.A., Wohlschlegel, J.A., Jacobsen, S.E. SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV. (2011) PLOS Genetics. 7(7):e1002195. DOI: 10.1371/journal.pgen.1002195

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Greenberg, M.V., Ausin, I., Chan, S.W., Cokus, S.J., Cuperus, J.T., Feng, S., Law, J.A., Chu, C., Pellegrini, M., Carrington, J.C., Jacobsen, S.E. Identification of genes required for de novo DNA methylation in Arabidopsis. (2011) Epigenetics. 6(3):344-54.

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Rajakumara, E., Law, J.A., Simanshu, D.K., Voigt, P., Johnson, L.M., Reinberg, D., Patel, D.J., Jacobsen, S.E. A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. (2011) Genes & Development. 25(2):137-52. DOI: 10.1101/gad.1980311

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Guo, L., Yu, Y., Law, J.A., Zhang, X. SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(43):18557-62. DOI: 10.1073/pnas.1010478107

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Law, J.A., Ausin, I., Johnson, L.M., Vashisht, A.A., Zhu, J.K., Wohlschlegel, J.A., Jacobsen, S.E. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. (2010) Current Biology. 20(10):951-6. DOI: 10.1016/j.cub.2010.03.062

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Law, J.A., Jacobsen, S.E. Establishing, maintaining and modifying DNA methylation patterns in plants and animals. (2010) Nature Reviews Genetics. 11(3):204-20. DOI: 10.1038/nrg2719

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Law, J.A., Jacobsen, S.E. Molecular biology. Dynamic DNA methylation. (2009) Science. 323(5921):1568-9. DOI: 10.1126/science.1172782


Johnson, L.M., Law, J.A., Khattar, A., Henderson, I.R., Jacobsen, S.E. SRA-domain proteins required for DRM2-mediated de novo DNA methylation. (2008) PLOS Genetics. 4(11):e1000280. DOI: 10.1371/journal.pgen.1000280

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Law, J.A., O'Hearn, S.F., Sollner-Webb, B. Trypanosoma brucei RNA editing protein TbMP42 (band VI) is crucial for the endonucleolytic cleavages but not the subsequent steps of U-deletion and U-insertion. (2008) RNA. 14(6):1187-200. DOI: 10.1261/rna.899508

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Law, J.A., O'Hearn, S., Sollner-Webb, B. In Trypanosoma brucei RNA editing, TbMP18 (band VII) is critical for editosome integrity and for both insertional and deletional cleavages. (2007) Molecular and Cellular Biology. 27(2):777-87. DOI: 10.1128/MCB.01460-06

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Zhelonkina, A.G., O'Hearn, S.F., Law, J.A., Cruz-Reyes, J., Huang, C.E., Alatortsev, V.S., Sollner-Webb, B. T. brucei RNA editing: action of the U-insertional TUTase within a U-deletion cycle. (2006) RNA. 12(3):476-87. DOI: 10.1261/rna.2243206

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Law, J.A., Huang, C.E., O'Hearn, S.F., Sollner-Webb, B. In Trypanosoma brucei RNA editing, band II enables recognition specifically at each step of the U insertion cycle. (2005) Molecular and Cellular Biology. 25(7):2785-94. DOI: 10.1128/MCB.25.7.2785-2794.2005

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Education

BS, Biochemistry and Biophysics, Oregon State University
PhD, Biochemistry, Johns Hopkins University School of Medicine
Postdoctoral Fellow, University of California, Los Angeles


Awards & Honors

  • Rita Allen Scholar Award, 2015
  • Ruth L. Kirschstein National Research Service Award, National Institutes of Health, 2007
  • Howard Hughes Medical Institute Summer Fellowship, Oregon State University, 2000