Jean Rivier

Professor Emeritus

Clayton Foundation Laboratories for Peptide Biology

Jean Rivier


Jean Rivier pioneered studies on the biology of stress and has developed drugs that target the body’s stress response system.


Rivier spent his career as a Salk professor studying a class of stress hormones called corticotropin-releasing factors (CRFs). He showed that CRFs are responsible for many of the body’s reactions to stress, including disabling the immune system in irritable bowel syndrome (IBS). In an attempt to develop treatments for these conditions, he designed peptide molecules that block CRF receptors. He recently founded a company called Sentia Medical Sciences Inc. and obtained exclusive rights to CRF-targeted molecules from the Salk Institute. Aside from his contributions to understanding stress, his work has resulted in eight drugs used to diagnose and treat neuroendocrine tumors, prostate cancer, hypogonadism, pituitary dwarfism and intractable pain.


Chemical Engineering, Ecole Polytechnique of the University of Lausanne, Switzerland
PhD, Organic Chemistry, Ecole Polytechnique of the University of Lausanne
Postdoctoral Fellow, Rice University

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