Jan Karlseder

Professor

Molecular and Cell Biology Laboratory

Donald and Darlene Shiley Chair

Salk Institute for Biological Studies - News

News


The Goldilocks effect in aging research

LA JOLLA—Ever since researchers connected the shortening of telomeres—the protective structures on the ends of chromosomes—to aging and disease, the race has been on to understand the factors that govern …


Targeting telomeres, the timekeepers of cells, could improve chemotherapy

LA JOLLA–Telomeres, specialized ends of our chromosomes that dictate how long cells can continue to duplicate themselves, have long been studied for their links to the aging process and cancer. …


Salk’s Glenn Center for Aging Research receives an additional $3 million gift from the Glenn Foundation for Medical Research

LA JOLLA—The Salk Institute has received a $3 million gift from the Glenn Foundation for Medical Research to allow the Institute to continue conducting research to understand the biology of …


Salk scientists identify factors that trigger ALT-ernative cancer cell growth

LA JOLLA, CA—Highly diverse cancers share one trait: the capacity for endless cell division. Unregulated growth is due in large part to the fact that tumor cells can rebuild protective …


Critical pathway in cell cycle may lead to cancer development

LA JOLLA,CA—A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer …


Chromosome “anchors” organize DNA during cell division

LA JOLLA, CA—For humans to grow and to replace and heal damaged tissues, the body’s cells must continually reproduce, a process known as “cell division,” by which one cell becomes …


Salk professors awarded chair appointments

LA JOLLA, CA—The Salk Institute is pleased to announce that professors E.J. Chichilnisky, Jan Karlseder, and Kuo-Fen Lee have each been selected as the recipient of an endowed chair to …


Salk scientists open new window into how cancers override cellular growth controls

LA JOLLA, CA—Rapidly dividing cancer cells are skilled at patching up damage that would stop normal cells in their tracks, including wear and tear of telomeres, the protective caps at …


Sending out an SOS: How telomeres incriminate cells that can’t divide

LA JOLLA, CA—The well-being of living cells requires specialized squads of proteins that maintain order. Degraders chew up worn-out proteins, recyclers wrap up damaged organelles, and-most importantly-DNA repair crews restitch …


A new ending to an old “tail”

LA JOLLA, CA—In stark contrast to normal cells, which only divide a finite number of times before they enter into a permanent state of growth arrest or simply die, cancer …


Salk Institute promotes latest generation of extraordinary scientists

LA JOLLA, CA—After undergoing an extensive review process by Salk senior faculty, Non-Resident Fellows, and scientific leaders in their respective fields, Leanne Jones and Satchidananda Panda have been promoted to …


Ticking of a cellular clock promotes seismic changes in the chromatin landscape associated with aging

LA JOLLA, CA—Like cats, human cells have a finite number of lives-once they divide a certain number of times (thankfully, more than nine) they change shape, slow their pace, and …


How worms protect their chromosomes: Thereby hangs a surprising tail

La Jolla, CA – A team of scientists at the Salk Institute for Biological Studies has discovered that the roundworm C. elegans constructs the protective tips of its chromosomes – …


FISH-ing for links between cancer and aging

La Jolla, CA – Wielding a palette of chromosome paints, scientists at the Salk Institute for Biological Studies have taken a step closer to understanding the relationship between …


DNA repair teams’ motto: ‘To protect and serve’

La Jolla, CA – When you dial 911 you expect rescuers to pull up at your front door, unload and get busy – not park the truck down …


Normal chromosome ends elicit a limited DNA damage response

La Jolla, CA – Researchers at the Salk Institute for Biological Studies discovered that cells co-opted the machinery that usually repairs broken strands of DNA to protect the integrity of …


Tiny roundworm’s telomeres help scientists to tease apart different types of aging

La Jolla, CA – The continual and inevitable shortening of telomeres, the protective “caps” at the end of all 46 human chromosomes, has been linked to aging and physical decline. …


Salk Scientists Provide Insight into Aging

La Jolla, CA – Scientists at the Salk Institute have provided a startling insight into how cells age that might lead to new approaches for treating cancer and even aging …


Education

BS, Biology, University of Innsbruck, Austria
PhD, Molecular Biology, University of Vienna


Awards & Honors

  • 2002 The V-Foundation Award for Developing Scientists
  • 1999 Charles H. Revson Fellowship
  • 1997 Human Frontiers Science Program Fellowship
  • 1993 European Molecular Biology Organization Fellowship