Humans are built to hunger for fat, packing it on during times of feast and burning it during periods of famine. But deluged by foods rich in fat and sugar, the modern waistline often far exceeds the need to store energy for lean times. The result has been an epidemic of metabolic diseases. At Salk, we are deciphering the blueprint for metabolism, the complicated biological system that evolved to store and burn food for energy. These blueprints allow us to identify the molecular and genetic causes of obesity, diabetes and other metabolism-related disorders. We’re developing the next generation of obesity and diabetes therapies. We know that what’s needed now are powerful cures to fight a growing epidemic.