| title/gene/configuration |
principal investigator |
applications/disease types |
references |
salkno. |
| PPAR-delta Transgenic Mouse (Marathon Mouse) |
Ronald Evans |
Regulation of muscle fiber type and increased running endurance, obesity resistance |
Non-confidential Description (MarathonMouse.pdf); PLoS Biology 2(10/e294) (October 2004) |
|
| Transgenic Animals at a Nuclear Hormone Receptor Locus having Utility as a Model System for Studying (ADD)/ (ADHD) ** |
Carrolee Barlow |
ADD/ADHD |
Published U.S. Patent Application 2002-0133837A1 |
S00033 |
| System and Method for Controlling Male Fertility ** |
Tony Hunter |
Male Fertility, suppress sperm formation |
Nat Genet 24(2):157-62 (Feb 2000); Published U.S. Patent Application 2003-0084466 |
S00001 |
| Transgenic Animal Models Containing a Conditional ErbB2 Transgene ** |
Kuo-Fen Lee |
Transgenic animals for study and manipulation of erbB2 function; oncology, CNS, cardiovascular applications |
Neuron, Vol. 23, 273-283 (June 1999); Nature Medicine, Vol. 8, 459-465 (May 2002) |
S00020 |
| Severe Liver Degeneration in Mice Lacking the IkB Kinase 2 Gene |
Kuo-Fen Lee; Inder Verma |
Growth and development, TNF-alpha activation |
Science 284:321-325 (April 1999) |
|
| ErbB4 Gene Deleted Mice |
Greg Lemke |
CNS, cardiac muscle differentiation |
Nature, 378: 390-394 (1995); Nat Cell Biol. 2(2):103-9 (Feb. 2000); Am J Hum Genet. 71(4):877-892 (Oct. 2002) |
|
| Regulation of the Immune System by Receptor Tyrosine Kinases (TAM) |
Greg Lemke |
Autoimmune, Cardiovascular and CNS diseases |
Science, 393:306-311 (July 2001) |
S00034 |
| Motor Neuron Specific Promoter and Use Thereof ** |
Samuel Pfaff |
The minimal promoter for HB9 linked to an exogenous gene to treat neurological diseases and spinal cord injury; transgenic animals for studying cellular and tissue motor neuron disorders or for use in drug screening |
Neuron 23:675-687 (Aug. 1999) |
S99038 |
| Corticotropin-Releasing Factor Overproducing Transgenic Mice |
Wylie W. Vale, Jr. |
Transgenic mouse useful to screen compounds that modulate corticotropin-releasing factor levels |
Endocrinology 130: 3378-3386 (1992); J. Neuroscience 14: 2579-2584 (1994); U.S. Patent No. 6,023,011 Issued 2/8/2000; U.S. Patent No. 6,166,287 issued 12/20/2000 |
S93011 |
| IKK1 Deficient Mice Exhibit Abnormal Development of Skin and Skeleton |
Inder Verma |
Skin and skeletal development, functions of IKKs |
Genes & Development 13:1322-1328 (1999) |
|
| Factor IX Deficient Mice |
Inder Verma |
Hemophilia B model |
PNAS 94:11563-11566 (October 1997) |
|
| Site-Specific Recombination in Eukaryotes (PrmCre Mice) ** |
Geoff Wahl |
Five lines of transgenic mice containing a fusion gene encoding the mouse protamine 1 gene promoter and the Cre recombinase gene, ProCre; for efficient manipulation of chromosomal sequences |
PNAS 94:14602-14607 (December 1997); Published PCT Application WO9910488 |
S97025 |
| Receptor-Deficient Animals and Cell Lines |
Ronald Evans |
Mutant mice which enable the functional analysis of individual receptor genes to be carried out in vivo. |
Genes & Development 8:1007-1018 (1994); U.S. Patent No. 6,278,040 Issued 8/21/2001 |
S97027 |
| PPARg ; b-gal knock-in |
Ronald Evans |
Type II Diabetes, Atherosclerosis, Obesity |
Molecular Cell 4: 585–595 (October 1999) |
|
| PPARg; floxed ** |
Ronald Evans |
Type II Diabetes, Atherosclerosis, Obesity |
unpublished |
|
| PPARd null; b-gal knock-in |
Ronald Evans |
Atherosclerosis |
|
|
| PPARd null; internal deletion - with b-gal knock-in ** |
Ronald Evans |
Atherosclerosis |
PNAS 99(5): 2613–2618 (March 2002); PNAS 99(1): 303-308 (January 2002) |
|
| PPARd floxed ** |
Ronald Evans |
Atherosclerosis |
unpublished |
|
| PPARg null x PPARg floxed ** |
Ronald Evans |
Type II Diabetes, Atherosclerosis, Obesity |
unpublished |
|
| PPARg - VP16 Tg |
Ronald Evans |
Type II Diabetes, Atherosclerosis, Obesity |
unpublished |
|
| PPARg - null ES cells |
Ronald Evans |
Cancer |
Molecular Cell 7:161–171 (January 2001); Nature Med 7:48-52 (2000) |
|
| PPARd-V16Tg |
Ronald Evans |
Atherosclerosis |
unpublished |
|
| PPARd - null ES cells |
Ronald Evans |
Atherosclerosis |
unpublished |
|
| TLXnull; b-gal knock-in |
Ronald Evans |
Neurodegenerative diseases |
PNAS 97(6): 2621-2625 (March 2000) |
|
| VgEcR/RXR |
Ronald Evans |
Parkinson's, Huntington's |
PNAS 97(26):14512-14517 (Dec. 2000) |
|
| hSXR-Tg |
Ronald Evans |
Xenobiotic (drug interaction) |
Nature, Letters to Nature 406:435-439 (July 2000); Genes and Development 14:3014-3023 (2000); PNAS 98:3375-3380 (2001) |
|
| mCAR - VP |
Ronald Evans |
Xenobiotic (drug interaction) |
unpublished |
|
| IsK Knockout Mouse |
Steve Heinemann |
Mouse model for waltzer syndrome exhibiting hyperactivity, head tilt and bobbing |
Workshop on Inner Ear Biology, August 31 - September 3, 1996, Utrecht, The Netherlands; Neuron 17: 1251-1264 (1996) |
