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Animal Models available for licensing

Animal Models available for licensing

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For more information about licensing these models please contact Robert MacWright (rmacwright@salk.edu or X1703)



Title/gene/configuration Principal Investigator Application References Salk #
Transgenic Animal Having a Modified Nuclear Hormone Receptor Barlow ADD/ADHD S00033
Nte deficient mice
(Jackson Lab Strain 5091)
Barlow Hyperactivity, Organ- ophasphate mediated neurotoxicity S02005
 
Transgenic Mice Expressing a Human SXR Receptor Polypeptide (Alb-hSXR-Tg and FABP-hSXR-Tg mice available) Evans Xenobiotic (drug interaction) S97047B
mCAR-VP16 Tg mice Evans Xenobiotic (drug interaction) T09000
Receptor-Deficient Animals and Cell Lines Derived Therefrom, and Uses Thereof Evans Mutant mice which enable the functional analysis of indvidual receptor genes to be carried out in vivo. S97027
PPARg null; b-gal knock-in mice
(Jackson Lab Strain 6142)
Evans Type II Diabetes, Atherosclerosis, Obesity T09001
PPARg floxed mice
(Jackson Lab Strain 4584)
Evans Type II Diabetes, Atherosclerosis, Obesity T09002
PPARg Transgenic Mice (PPARg-VP16 Tg) Evans Type II Diabetes, Atherosclerosis, Obesity, Oncology T09003
PPARg-null ES cells Evans Oncology, Gene expression, Atherosclerosis, Cholesterol efflux, Macrophage functions T09004
PPARd transgenic mice (Marathon Mouse- PPARd-VP16-Tg under alpha-skeletal actin promoter; aP2-PPARd-VP16-Tg mice also available) Evans Regulation of muscle fiber type and increased running edurance, Obesity resistance T09005
PPARd null; b-gal knock-in mice
(Jackson Lab Strain 5901)
Evans Atherosclerosis
  • unpublished
T09006
PPARd floxed mice
(Jackson Lab Strain 5897)
Evans Atherosclerosis, Obesity and Oncology T09007
PPARd-null ES cells Evans Atherosclerosis T09008
TLX null; b-gal knock-in mice Evans Neurodegenerative diseases, Schizophrenia, Mood T09009
VgEcR/RXR expressing mice Evans Model system for rapid inducible gene expression; applications may include neuronal function, metabolism, signaling, development, oncology, apoptosis, etc. T09010
 
IsK knock-out mouse
(Jackson Lab Strain 3009)
Heinemann Mouse model for Waltzer Syndrome, exhibiting hyperactivity, head tilt and bobbing T09011
Nicotinic a9 receptor subunit knock-out mouse
(Jackson Lab Stain 5696)
Heinemann Development of cochlear hair cell innervation; auditory function T09047
 
System and Method for Controlling Male Fertility: Kit/SCF-R Y719F transgenic mice Hunter Male Fertility, suppress sperm formation S00001
 
Transgenic Animal Models Containing a Conditional ErbB2 Transgene Lee ErbB2 functions; oncology, CNS, cardiovascular applications S00020
 
A Novel Animal Model for Studying Anticoagulants: Protein S Deficient Mice Lemke Drug discovery, stroke, thrombosis, lupus and autoimmunity S08022
Receptor Tyrosine Kinase deficient mice: Tyro 3, Axl, and Mer single, double, and triple knock-out mice
(Tyro 3 knock-out Jackson Lab Strain 7937)
Lemke Autoimmune, Cardiovascular and CNS diseases S00034
ErbB4 Gene Deleted Mice
(MMRRC strain 010461)
Lemke CNS, Cardiac muscle differentiation T09012
 
TORC1 (Crtc1) knock-out mice Montminy CREB mediated gene expression, appetite regulation and obesity, fertility T09027
 
RORa-IRES-Cre knock-in mice O'Leary Mouse line useful for deletion of alleles in specific neuronal areas (ie dorsal thalamic nuclei, Suprachiasmatic nucleus, Purkinje cells, and spinal cord interneurons) for study of sensory functions and circadian rhythms.
  • unpublished
T09013
Emx2 conditional knock-out mice (Emx2 floxed) O'Leary Selective deletion of floxed Emx2 alleles by crossing with Cre lines for study of brain (especially cortex and hippocampus) and kidney development and function.
  • unpublished
T09014
nestin-Emx2 Tg mice O'Leary Brain (especially cortex and hippocampus) and kidney development. T09015
MDGA-1 conditional knock-out mice O'Leary MDGA1 is an IgCAM. Selective deletion of floxed MDGA-1 alleles by crossing with Cre lines for study of neuronal migration, cell adhesion, Schizophrenia, Oncology
  • unpublished
T09016
Lhx2 (LIM homeobox 2) conditional knock-out mice (Lhx2 floxed) O'Leary Selective deletion of floxed Lhx2 alleles by crossing with Cre lines for study of craniofacial, hematopoietic system, liver/biliary system, nervous system, vision/eye. T09017
Lhx2 conditional gain-of-function Tg mice O'Leary Selective expression of Lhx2 transgene by crossing with Cre lines for study of craniofacial, hematopoietic system, liver/biliary system, nervous system, vision/eye.
  • unpublished
T09018
PAX-6 conditional gain-of-function Tg mice O'Leary Selective expression of Pax6 transgene by crossing with Cre lines for study of craniofacial, brain and spinal cord, eye / retina, renal/kidney, skeleton.
  • unpublished
T09019
Foxg1-IRES-Cre knock-in mice O'Leary Deletion of floxed alleles with recombination patterns resembling the pattern of Foxg1 (i.e. BF1) expression, including the telencephalon, nasal retina, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction, and pharyngeal pouches. An IRES-Cre construct was inserted into the 3' UTR of the Foxg1 gene retaining normal expression and function of Foxg1 even in mice homozygous for the knock-in allele .
  • unpublished
T13000
 
Motor Neuron Specific Promoter and use thereof Pfaff Minimal promoter for HB9 linked to exogenous gene to treat neurological diseases and spinal cord injury; transgenic animals for studying cellular and tissue motor neuron disorders or for drug screening S99038
 
moca knock-out mice Schubert Age-related neuro-degeneration; Alzheimer's disease, Huntington's disease, ALS T09045
 
Non-Mammalian Animal Models with Glioma for Cancer Discovery Thomas Drug Discovery and Development, Oncology S08023
 
Corticotropin-Releasing Factor Overproducing Transgenic Mice
(Jackson Lab Strain 3210)
Vale Transgenic mouse useful to screen compounds that modulate cortico-tropin-releasing factor levels S93011
 
Severe liver degeneration in mice lacking the IkB Kinase 2 Gene Verma Growth and development, TNF-a activation S99013
IKK1 deficient mice exhibit abnormal development of skin and skeleton Verma Functions of IKKs; skin and skeletal development S99012
Factor IX deficient mice Verma Hemophilia B model T09020
New tumor mouse models using lentiviral vectors Verma Oncology; mouse model for glioblastoma S07006B
 

Site-specific Recombination in Eukaryotes (PrmCre Mice)
(Jackson Lab Strain 3328)

Wahl Five lines of transgenic mice containing a fusion gene encoding the mouse protamine 1 gene promoter and the Cre recombinase gene (ProCre); for efficient manipulation of chromosomal sequences S97025

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