Animal Models available for licensing
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For more information about licensing these models please contact Robert MacWright (rmacwright@salk.edu or X1703)
| Title/gene/configuration | Principal Investigator | Application | References | Salk # |
|---|---|---|---|---|
| Transgenic Animal Having a Modified Nuclear Hormone Receptor | Barlow | ADD/ADHD | S00033 | |
| Nte deficient mice (Jackson Lab Strain 5091) |
Barlow | Hyperactivity, Organ- ophasphate mediated neurotoxicity | S02005 | |
| Transgenic Mice Expressing a Human SXR Receptor Polypeptide (Alb-hSXR-Tg and FABP-hSXR-Tg mice available) | Evans | Xenobiotic (drug interaction) | S97047B | |
| mCAR-VP16 Tg mice | Evans | Xenobiotic (drug interaction) | T09000 | |
| Receptor-Deficient Animals and Cell Lines Derived Therefrom, and Uses Thereof | Evans | Mutant mice which enable the functional analysis of indvidual receptor genes to be carried out in vivo. | S97027 | |
| PPARg null; b-gal knock-in mice (Jackson Lab Strain 6142) |
Evans | Type II Diabetes, Atherosclerosis, Obesity | T09001 | |
| PPARg floxed mice (Jackson Lab Strain 4584) |
Evans | Type II Diabetes, Atherosclerosis, Obesity | T09002 | |
| PPARg Transgenic Mice (PPARg-VP16 Tg) | Evans | Type II Diabetes, Atherosclerosis, Obesity, Oncology | T09003 | |
| PPARg-null ES cells | Evans | Oncology, Gene expression, Atherosclerosis, Cholesterol efflux, Macrophage functions | T09004 | |
| PPARd transgenic mice (Marathon Mouse- PPARd-VP16-Tg under alpha-skeletal actin promoter; aP2-PPARd-VP16-Tg mice also available) | Evans | Regulation of muscle fiber type and increased running edurance, Obesity resistance |
|
T09005 |
| PPARd null; b-gal knock-in mice (Jackson Lab Strain 5901) |
Evans | Atherosclerosis |
|
T09006 |
| PPARd floxed mice (Jackson Lab Strain 5897) |
Evans | Atherosclerosis, Obesity and Oncology | T09007 | |
| PPARd-null ES cells | Evans | Atherosclerosis | T09008 | |
| TLX null; b-gal knock-in mice | Evans | Neurodegenerative diseases, Schizophrenia, Mood | T09009 | |
| VgEcR/RXR expressing mice | Evans | Model system for rapid inducible gene expression; applications may include neuronal function, metabolism, signaling, development, oncology, apoptosis, etc. | T09010 | |
| IsK knock-out mouse (Jackson Lab Strain 3009) |
Heinemann | Mouse model for Waltzer Syndrome, exhibiting hyperactivity, head tilt and bobbing |
|
T09011 |
| Nicotinic a9 receptor subunit knock-out mouse (Jackson Lab Stain 5696) |
Heinemann | Development of cochlear hair cell innervation; auditory function | T09047 | |
| System and Method for Controlling Male Fertility: Kit/SCF-R Y719F transgenic mice | Hunter | Male Fertility, suppress sperm formation | S00001 | |
| Transgenic Animal Models Containing a Conditional ErbB2 Transgene | Lee | ErbB2 functions; oncology, CNS, cardiovascular applications | S00020 | |
| A Novel Animal Model for Studying Anticoagulants: Protein S Deficient Mice | Lemke | Drug discovery, stroke, thrombosis, lupus and autoimmunity | S08022 | |
| Receptor Tyrosine Kinase deficient mice: Tyro 3, Axl, and Mer single, double, and triple knock-out mice (Tyro 3 knock-out Jackson Lab Strain 7937) |
Lemke | Autoimmune, Cardiovascular and CNS diseases | S00034 | |
| ErbB4 Gene Deleted Mice (MMRRC strain 010461) |
Lemke | CNS, Cardiac muscle differentiation | T09012 | |
| TORC1 (Crtc1) knock-out mice | Montminy | CREB mediated gene expression, appetite regulation and obesity, fertility | T09027 | |
| RORa-IRES-Cre knock-in mice | O'Leary | Mouse line useful for deletion of alleles in specific neuronal areas (ie dorsal thalamic nuclei, Suprachiasmatic nucleus, Purkinje cells, and spinal cord interneurons) for study of sensory functions and circadian rhythms. |
|
T09013 |
| Emx2 conditional knock-out mice (Emx2 floxed) | O'Leary | Selective deletion of floxed Emx2 alleles by crossing with Cre lines for study of brain (especially cortex and hippocampus) and kidney development and function. |
|
T09014 |
| nestin-Emx2 Tg mice | O'Leary | Brain (especially cortex and hippocampus) and kidney development. | T09015 | |
| MDGA-1 conditional knock-out mice | O'Leary | MDGA1 is an IgCAM. Selective deletion of floxed MDGA-1 alleles by crossing with Cre lines for study of neuronal migration, cell adhesion, Schizophrenia, Oncology |
|
T09016 |
| Lhx2 (LIM homeobox 2) conditional knock-out mice (Lhx2 floxed) | O'Leary | Selective deletion of floxed Lhx2 alleles by crossing with Cre lines for study of craniofacial, hematopoietic system, liver/biliary system, nervous system, vision/eye. | T09017 | |
| Lhx2 conditional gain-of-function Tg mice | O'Leary | Selective expression of Lhx2 transgene by crossing with Cre lines for study of craniofacial, hematopoietic system, liver/biliary system, nervous system, vision/eye. |
|
T09018 |
| PAX-6 conditional gain-of-function Tg mice | O'Leary | Selective expression of Pax6 transgene by crossing with Cre lines for study of craniofacial, brain and spinal cord, eye / retina, renal/kidney, skeleton. |
|
T09019 |
| Foxg1-IRES-Cre knock-in mice | O'Leary | Deletion of floxed alleles with recombination patterns resembling the pattern of Foxg1 (i.e. BF1) expression, including the telencephalon, nasal retina, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction, and pharyngeal pouches. An IRES-Cre construct was inserted into the 3' UTR of the Foxg1 gene retaining normal expression and function of Foxg1 even in mice homozygous for the knock-in allele . |
|
T13000 |
| Motor Neuron Specific Promoter and use thereof | Pfaff | Minimal promoter for HB9 linked to exogenous gene to treat neurological diseases and spinal cord injury; transgenic animals for studying cellular and tissue motor neuron disorders or for drug screening | S99038 | |
| moca knock-out mice | Schubert | Age-related neuro-degeneration; Alzheimer's disease, Huntington's disease, ALS | T09045 | |
| Non-Mammalian Animal Models with Glioma for Cancer Discovery | Thomas | Drug Discovery and Development, Oncology | S08023 | |
| Corticotropin-Releasing Factor Overproducing Transgenic Mice (Jackson Lab Strain 3210) |
Vale | Transgenic mouse useful to screen compounds that modulate cortico-tropin-releasing factor levels | S93011 | |
| Severe liver degeneration in mice lacking the IkB Kinase 2 Gene | Verma | Growth and development, TNF-a activation | S99013 | |
| IKK1 deficient mice exhibit abnormal development of skin and skeleton | Verma | Functions of IKKs; skin and skeletal development | S99012 | |
| Factor IX deficient mice | Verma | Hemophilia B model | T09020 | |
| New tumor mouse models using lentiviral vectors | Verma | Oncology; mouse model for glioblastoma | S07006B | |
Site-specific Recombination in Eukaryotes (PrmCre Mice) |
Wahl | Five lines of transgenic mice containing a fusion gene encoding the mouse protamine 1 gene promoter and the Cre recombinase gene (ProCre); for efficient manipulation of chromosomal sequences | S97025 | |
