Salk Institute

Technology for Gene Expression

Technology for Gene Expression

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S06007: Callaway

Understanding Neural Networks: Identifying Monosynaptic Connections
Technology that enables specific labeling and/or manipulation of neural networks

S04009B: Choe

Compositions and Methods for Producing Recombinant Membrane-Associated Proteins
A 'partner' molecule called Mistic makes widespread production of large quantities of membrane proteins possible for the first time, allowing scientists to determine their atomic structure and design drugs that interfere with disease processes involving crucial proteins such as ion channels and GPCRs.

S00004: Emerson

Method of Regulating Transcription in a Cell and Methods of Modulating Gene Expression
Chromatin based technology to define novel and highly specific protein targets for selective gene modulation

S09026: Evans

Adipose-derived Induced Pluripotent Stem Cells
Model system for studying the molecular mechanisms of feeder-free iPS generation and maintenance

S98002: Evans

Formulations Useful for Modulating Expression of Exogenous Genes in Mammalian Systems, and Products Related There
In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in a mammalian subject employing modified ecdysone receptors.

S98001: Evans

Products Useful for Modulating Expression of Exogenous Genes in Mammalian Systems
Modulation of exogenous gene expression in mammalian and other systems using modified ecdysone receptors

S91020: Evans

Bioassays for Identifying Antagonists of Receptors of the Steroid/ Thyroid Superfamily
The present invention relates to bioassays for evaluating compounds as potential antagonists for members of the steroid hormone superfamily of receptor protein(s).

S09023: Gage

A New Diagnostic Assay: Measuring Retrotransposition in Man
L1 retrotransposition in human neural progenitor cells

S08017: Gage

Pluripotent Stem Cells from Neuronal Cells
Transcriptional analysis of virus-free human induced pluripotent cells

S04010: Gage

A Molecular Switch Regulating Neurogenesis
A "master switch" that determines whether the genetic program that mediates neural differentiation is repressed or activated

S98035: Gage

Regulation of Tyrosine Hydroxylase Expression
Nurr1 polypeptide upregulates tyrosine hydroxylase activity and promotes expression of DOPA, norepinenephrine and epinephrine.

S98032: Gage

Hormone Receptor Functional Dimers and Methods of Use

S97001: Gage

Modified Lepidopteran Receptors and Hybrid Multifunctional Proteins for Use in Transcription and Regulation of Transgene Expression
This invention relates to nuclear receptor proteins isolated from the silk moth bombyx mori (bR) which are useful for the regulation of transgene expression.

S96013: Gage

Modular Assembly Retroviral Vectors and Uses Therefor
Gene transfer vectors with the capacity for prolonged or modulated transgene expression

S97031: Hope

Stimulation of Transgene Expression by RNA Export Elements
Enhance transgene expression by promoting correct processing and transport of RNA from the cell nucleus to the cytoplasm.

S09011: Izpisua Belmonte

Increased Reprogramming for Generating Pluripotent Stem Cells
Induced pluripotent stem (iPS) cell generation using two factors and p53 inactivation

S09007: Izpisua Belmonte

A Step Toward Safe Derivation of Clinically Relevant Human Induced Pluripotent Stem Cells
A single plasmid construct that expresses four transcription factors from one polycistronic unit

S08024: Izpisua Belmonte

Production of Induced Pluripotent Stem Cells: Generation from a Single Hair
Induced Pluripotent Stem Cells and Methods of Use

S06006: Noel

Metabolic engineering of lipid metabolism by improving fatty acid binding and transport
Metabolic pathway engineering of lipids in plants; protein crystallography and design.

S04008B: Noel

Novel Aromatic Prenyltransferases, Nucleic Acids Encoding Same and Uses Therefor
Enzyme that transfers a prenyl group is found to be unexpectedly promiscuous

pCL: Verma

pCL Vector System: Rapid Production of Helper-Free, High-Titer, Recombinant Retroviruses
Maximize recombinant-retrovirus titers in a simple, robust, and flexible experimental system.

S97025: Wahl

Site-Specific Recombination in Eukaryotes and Constructs Useful Therefor
A fusion of the protamine 1 gene promoter with the Cre recombinase gene for efficient manipulation of chromosomal sequences in mammalian systems

S09008: Wang

Increasing Unnatural Amino Acid Incorporation 5-Fold in Mammalian Cells
Improved orthogonal tRNA-synthetase recognition for efficient unnatural amino acid incorporation and application in mammalian cells

S07007: Wang

Methods of Genetically Encoding Unnatural Amino Acids in Eukaryotic Cells Using Orthogonal TRNA/Synthetase Pairs
Genetic encoding of novel amino acids in mammalian cells, high-yield production of unnatural amino acids and novel proteins.

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