Technology for Drug Discovery and Development
Method of Rapidly Identifying Inhibitors of Topoisomerase DNA Religation
High throughput screen for compounds that modulate topoisomerase activity
Assay for Integration Inhibitors Using Pre-Integration Complexes
A screen for viral integrase inhibitors
Understanding Neural Networks: Identifying Monosynaptic Connections
Technology that enables specific labeling and/or manipulation of neural networks
Epigenetic Silencing of Tumor Suppressor Genes
Epigenetic silencing of tumor suppressor genes occurs through loss of CTCF binding and chromatin boundaries
Method of Regulating Transcription in a Cell and Methods of Modulating Gene Expression
Chromatin based technology to define novel and highly specific protein targets for selective gene modulation
Adipose-derived Induced Pluripotent Stem Cells
Model system for studying the molecular mechanisms of feeder-free iPS generation and maintenance
Use of RAR Antagonists as Modulators of Hormone Mediated Processes
RAR Antagonists are capable of modulating processes mediated by other members of the steroid/thyroid hormone receptor superfamily, including permissive receptors such as PPARs.
Treatment of Disease States which Result from Neoplastic Cell Proliferation Using PPAR-gamma Activators and Compositions Useful Therefor
Administration of PPAR-gamma agonists, optionally in combination with RXR specific agonists, can block neoplastic cell proliferation
Treatment of Liposarcomas Using a Combination of Thiazolidinediones and Retinoid X Receptor Selective Agonists
Compositions useful for the treatment of liposarcomas
Selective Modulators of PPAR-gamma and Methods for the Use Thereof
Use of PPAR-gamma-selective compounds for the treatment of obesity and diabetes.
Pluripotent Stem Cells from Neuronal Cells
Transcriptional analysis of virus-free human induced pluripotent cells
Human Cell Assay for Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative adult disease characterized by fatal paralysis in both the brain and spinal cord motor neurons due to motor neuron death.
Transcription Factor Regulating FGF-2 and Variants Thereof
Genes which encode polypeptides that are FGF-2 regulators of transcription
Kainate Receptor Subunit GluR7 Polymorphisms for Diagnosing Predisposition and for Therapy of Mood Disorders
The Kainate Receptor Subunit GluR7 Gene is Associated with Mood Disorders
S09011: Izpisua Belmonte
Increased Reprogramming for Generating Pluripotent Stem Cells
Induced pluripotent stem (iPS) cell generation using two factors and p53 inactivation
S09007: Izpisua Belmonte
A Step Toward Safe Derivation of Clinically Relevant Human Induced Pluripotent Stem Cells
A single plasmid construct that expresses four transcription factors from one polycistronic unit
S08024: Izpisua Belmonte
Production of Induced Pluripotent Stem Cells: Generation from a Single Hair
Induced Pluripotent Stem Cells and Methods of Use
Cyclin T, A New HIV Target
Materials and methods useful for identifying compounds that prevent binding of Cyclin T to HIV Tat, thus disrupting HIV's infection cycle.
Alpha-Complementation Viral Fusion Assay
A rapid and quantitative assay to detect HIV and other viral mediated fusion to screen for inhibitors
A Novel Animal Model for Studying Anticoagulants: Protein S Deficient Mice
Protein S (ProS) is a blood anticoagulant, and ProS deficiencies are associated with venous thrombosis, stroke, and autoimmunity.
Increasing Fat Metabolism: Identification of a New Pathway in Adipose Tissue
During fasting, adipose lipid stores are mobilized to provide fatty acids for use as a metabolic energy source.
Modulating Gluconeogenesis: Indirect Phosphorylation of TORC2 from Insulin.
Glucose levels are maintained within a narrow range in humans through counter-regulatory effects of pancreatic hormones on hepatic gluconeogenesis, including insulin.
Protein Kinase B/AKT Modulators and Methods of Use Thereof
A protein, TRB3, found to be overexrpessed in response to diabetes and fasting is an attractive drug target in the treatment of type II diabetes.
Novel Aromatic Prenyltransferases, Nucleic Acids Encoding Same and Uses Therefor
Enzyme that transfers a prenyl group is found to be unexpectedly promiscuous
Modulation of Mevalonate-Independent Isoprenoid Biosynthetic Pathway
Templates for the design of novel antibacterial and antiparasitic drugs
Controlling Axon Growth and Mapping in the Visual System
Axonal connections in the mature nervous system are extraordinarily precise.
Corticotropin-Releasing Factor (CRF) Antagonists
Drugs to activate CRF receptors based on peptide antagonists
Gonadotropin Releasing Hormone (GnRH) Analogs
Potent GnRH antagonists with significantly increased duration of action, useful for applications including fertility regulation, endometriosis, hormone-dependent tumors, and precocious puberty.
Methods of Inhibiting Poxvirus Growth
Targets for the development of anti-smallpox drugs
Imaging and Treatment of Intestinal Cancer: Peutz-Jeghers Syndrome
Gastrointestinal Disease or Disorder Imaging and Treatment
Kir Channel Modulators
Methods and materials for modulating Kir channel activity and identification of related compounds.
Non-Mammalian Animal Models with Glioma for Cancer Discovery
Gliomas, neoplasms of glial cells and their precursors, are the most common malignant tumors of the central nervous system (CNS).
Corticotropin-Releasing Factor Overproducing Transgenic Mice
Transgenic mouse useful to screen compounds that modulate corticotropin-releasing factor levels
IKK2: A Central Player in Allergic Reactions
Methods of identifying IKK2 activators or inhibitors for regulation of mast cell degranulation
Non-Nucleoside Reverse Transcriptase Inhibitors
Novel NNRTIs, compounds and pharmaceutical compositions for reducing HIV infection and replication.
A Novel Antitoxin and Vaccine Platform Based on Nodavirus VLPS
A novel, chimeric virus-like particle (VLP) capable of multivalent display of PA shows significant advantages over existing monovalent PA immunogens for anthrax toxin. Studies indicate VLP-PA complex may eliminate the need for lengthy immunization schedules by providing immunity after a single injection, and has potential to generate effective vaccines against other pathogens, including combination vaccines immunizing against multiple toxins.