Salk Institute

Technology for Drug Discovery and Development

Technology for Drug Discovery and Development

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S00014: Bushman

Method of Rapidly Identifying Inhibitors of Topoisomerase DNA Religation
High throughput screen for compounds that modulate topoisomerase activity

S97022B: Bushman

Assay for Integration Inhibitors Using Pre-Integration Complexes
A screen for viral integrase inhibitors

S06007: Callaway

Understanding Neural Networks: Identifying Monosynaptic Connections
Technology that enables specific labeling and/or manipulation of neural networks

S08001: Emerson

Epigenetic Silencing of Tumor Suppressor Genes
Epigenetic silencing of tumor suppressor genes occurs through loss of CTCF binding and chromatin boundaries

S00004: Emerson

Method of Regulating Transcription in a Cell and Methods of Modulating Gene Expression
Chromatin based technology to define novel and highly specific protein targets for selective gene modulation

S09026: Evans

Adipose-derived Induced Pluripotent Stem Cells
Model system for studying the molecular mechanisms of feeder-free iPS generation and maintenance

S96028: Evans

Use of RAR Antagonists as Modulators of Hormone Mediated Processes
RAR Antagonists are capable of modulating processes mediated by other members of the steroid/thyroid hormone receptor superfamily, including permissive receptors such as PPARs.

S96024A: Evans

Treatment of Disease States which Result from Neoplastic Cell Proliferation Using PPAR-gamma Activators and Compositions Useful Therefor
Administration of PPAR-gamma agonists, optionally in combination with RXR specific agonists, can block neoplastic cell proliferation

S96023A: Evans

Treatment of Liposarcomas Using a Combination of Thiazolidinediones and Retinoid X Receptor Selective Agonists
Compositions useful for the treatment of liposarcomas

S95031: Evans

Selective Modulators of PPAR-gamma and Methods for the Use Thereof
Use of PPAR-gamma-selective compounds for the treatment of obesity and diabetes.

S08017: Gage

Pluripotent Stem Cells from Neuronal Cells
Transcriptional analysis of virus-free human induced pluripotent cells

S08014: Gage

Human Cell Assay for Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative adult disease characterized by fatal paralysis in both the brain and spinal cord motor neurons due to motor neuron death.

S98015: Gage

Transcription Factor Regulating FGF-2 and Variants Thereof
Genes which encode polypeptides that are FGF-2 regulators of transcription

S00007: Heinemann

Kainate Receptor Subunit GluR7 Polymorphisms for Diagnosing Predisposition and for Therapy of Mood Disorders
The Kainate Receptor Subunit GluR7 Gene is Associated with Mood Disorders

S09011: Izpisua Belmonte

Increased Reprogramming for Generating Pluripotent Stem Cells
Induced pluripotent stem (iPS) cell generation using two factors and p53 inactivation

S09007: Izpisua Belmonte

A Step Toward Safe Derivation of Clinically Relevant Human Induced Pluripotent Stem Cells
A single plasmid construct that expresses four transcription factors from one polycistronic unit

S08024: Izpisua Belmonte

Production of Induced Pluripotent Stem Cells: Generation from a Single Hair
Induced Pluripotent Stem Cells and Methods of Use

S97041: Jones

Cyclin T, A New HIV Target
Materials and methods useful for identifying compounds that prevent binding of Cyclin T to HIV Tat, thus disrupting HIV's infection cycle.

S02016A: Landau

Alpha-Complementation Viral Fusion Assay
A rapid and quantitative assay to detect HIV and other viral mediated fusion to screen for inhibitors

S08022: Lemke

A Novel Animal Model for Studying Anticoagulants: Protein S Deficient Mice
Protein S (ProS) is a blood anticoagulant, and ProS deficiencies are associated with venous thrombosis, stroke, and autoimmunity.

S06002: Montminy

Increasing Fat Metabolism: Identification of a New Pathway in Adipose Tissue
During fasting, adipose lipid stores are mobilized to provide fatty acids for use as a metabolic energy source.

S04005: Montminy

Modulating Gluconeogenesis: Indirect Phosphorylation of TORC2 from Insulin.
Glucose levels are maintained within a narrow range in humans through counter-regulatory effects of pancreatic hormones on hepatic gluconeogenesis, including insulin.

S02011: Montminy

Protein Kinase B/AKT Modulators and Methods of Use Thereof
A protein, TRB3, found to be overexrpessed in response to diabetes and fasting is an attractive drug target in the treatment of type II diabetes.

S04008B: Noel

Novel Aromatic Prenyltransferases, Nucleic Acids Encoding Same and Uses Therefor
Enzyme that transfers a prenyl group is found to be unexpectedly promiscuous

S00010B: Noel

Modulation of Mevalonate-Independent Isoprenoid Biosynthetic Pathway
Templates for the design of novel antibacterial and antiparasitic drugs

S08010: OLeary

Controlling Axon Growth and Mapping in the Visual System
Axonal connections in the mature nervous system are extraordinarily precise.

S96032: Rivier

Corticotropin-Releasing Factor (CRF) Antagonists
Drugs to activate CRF receptors based on peptide antagonists

S96027: Rivier

Gonadotropin Releasing Hormone (GnRH) Analogs
Potent GnRH antagonists with significantly increased duration of action, useful for applications including fertility regulation, endometriosis, hormone-dependent tumors, and precocious puberty.

S05006: Sefton

Methods of Inhibiting Poxvirus Growth
Targets for the development of anti-smallpox drugs

S09022: Shaw

Imaging and Treatment of Intestinal Cancer: Peutz-Jeghers Syndrome
Gastrointestinal Disease or Disorder Imaging and Treatment

S06017: Slesinger

Kir Channel Modulators
Methods and materials for modulating Kir channel activity and identification of related compounds.

S08023: Thomas

Non-Mammalian Animal Models with Glioma for Cancer Discovery
Gliomas, neoplasms of glial cells and their precursors, are the most common malignant tumors of the central nervous system (CNS).

S93011: Vale

Corticotropin-Releasing Factor Overproducing Transgenic Mice
Transgenic mouse useful to screen compounds that modulate corticotropin-releasing factor levels

S08005: Verma

IKK2: A Central Player in Allergic Reactions
Methods of identifying IKK2 activators or inhibitors for regulation of mast cell degranulation

S07014: Young

Non-Nucleoside Reverse Transcriptase Inhibitors
Novel NNRTIs, compounds and pharmaceutical compositions for reducing HIV infection and replication.

S07001: Young

A Novel Antitoxin and Vaccine Platform Based on Nodavirus VLPS
A novel, chimeric virus-like particle (VLP) capable of multivalent display of PA shows significant advantages over existing monovalent PA immunogens for anthrax toxin. Studies indicate VLP-PA complex may eliminate the need for lengthy immunization schedules by providing immunity after a single injection, and has potential to generate effective vaccines against other pathogens, including combination vaccines immunizing against multiple toxins.

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