Salk Institute

Technology for CNS Applications

Technology for CNS Applications

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S06007: Callaway

Understanding Neural Networks: Identifying Monosynaptic Connections
Technology that enables specific labeling and/or manipulation of neural networks

S09023: Gage

A New Diagnostic Assay: Measuring Retrotransposition in Man
L1 retrotransposition in human neural progenitor cells

S09001: Gage

Computational Model of Neurogenesis
Role of Neurogenesis in Pattern Separation Neural Networks

S08017: Gage

Pluripotent Stem Cells from Neuronal Cells
Transcriptional analysis of virus-free human induced pluripotent cells

S08014: Gage

Human Cell Assay for Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative adult disease characterized by fatal paralysis in both the brain and spinal cord motor neurons due to motor neuron death.

S04010: Gage

A Molecular Switch Regulating Neurogenesis
A "master switch" that determines whether the genetic program that mediates neural differentiation is repressed or activated

S98035: Gage

Regulation of Tyrosine Hydroxylase Expression
Nurr1 polypeptide upregulates tyrosine hydroxylase activity and promotes expression of DOPA, norepinenephrine and epinephrine.

S00007: Heinemann

Kainate Receptor Subunit GluR7 Polymorphisms for Diagnosing Predisposition and for Therapy of Mood Disorders
The Kainate Receptor Subunit GluR7 Gene is Associated with Mood Disorders

S05002: Lee

Nerve Regeneration: Compositions and Methods
Methods and compositions for promoting nerve growth and/or regeneration, including what is believed to be the first demonstration of locomotor functional recovery following a complete spinal cord transection.

S08010: OLeary

Controlling Axon Growth and Mapping in the Visual System
Axonal connections in the mature nervous system are extraordinarily precise.

S96032: Rivier

Corticotropin-Releasing Factor (CRF) Antagonists
Drugs to activate CRF receptors based on peptide antagonists

S06017: Slesinger

Kir Channel Modulators
Methods and materials for modulating Kir channel activity and identification of related compounds.

S96012: Vale

A native mammalian peptide with potent hypotensive activity used as a therapeutic or target

S93011: Vale

Corticotropin-Releasing Factor Overproducing Transgenic Mice
Transgenic mouse useful to screen compounds that modulate corticotropin-releasing factor levels

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