Technology for CNS Applications
Understanding Neural Networks: Identifying Monosynaptic Connections
Technology that enables specific labeling and/or manipulation of neural networks
A New Diagnostic Assay: Measuring Retrotransposition in Man
L1 retrotransposition in human neural progenitor cells
Computational Model of Neurogenesis
Role of Neurogenesis in Pattern Separation Neural Networks
Pluripotent Stem Cells from Neuronal Cells
Transcriptional analysis of virus-free human induced pluripotent cells
Human Cell Assay for Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative adult disease characterized by fatal paralysis in both the brain and spinal cord motor neurons due to motor neuron death.
A Molecular Switch Regulating Neurogenesis
A "master switch" that determines whether the genetic program that mediates neural differentiation is repressed or activated
Regulation of Tyrosine Hydroxylase Expression
Nurr1 polypeptide upregulates tyrosine hydroxylase activity and promotes expression of DOPA, norepinenephrine and epinephrine.
Kainate Receptor Subunit GluR7 Polymorphisms for Diagnosing Predisposition and for Therapy of Mood Disorders
The Kainate Receptor Subunit GluR7 Gene is Associated with Mood Disorders
Nerve Regeneration: Compositions and Methods
Methods and compositions for promoting nerve growth and/or regeneration, including what is believed to be the first demonstration of locomotor functional recovery following a complete spinal cord transection.
Controlling Axon Growth and Mapping in the Visual System
Axonal connections in the mature nervous system are extraordinarily precise.
Corticotropin-Releasing Factor (CRF) Antagonists
Drugs to activate CRF receptors based on peptide antagonists
Kir Channel Modulators
Methods and materials for modulating Kir channel activity and identification of related compounds.
A native mammalian peptide with potent hypotensive activity used as a therapeutic or target
Corticotropin-Releasing Factor Overproducing Transgenic Mice
Transgenic mouse useful to screen compounds that modulate corticotropin-releasing factor levels