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Salk scientists discover previously unknown requirement for brain development

LA JOLLA—Scientists at the Salk Institute for Biological Studies have demonstrated that sensory regions in the brain develop in a fundamentally different way than previously thought, a finding that may yield new insights into visual and neural disorders.

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Singing superstar Katharine McPhee headlines Symphony at Salk on August 24

LA JOLLA, CA—On Aug. 24, 2013, multi-talented singer Katharine McPhee will step into the spotlight as the featured headliner for the 18th annual "Symphony at Salk-a concert under the stars" to perform with the San Diego Symphony and acclaimed guest conductor Maestro Thomas Wilkins.

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Scientists identify thousands of plant genes activated by ethylene gas

LA JOLLA, CA—It's common wisdom that one rotten apple in a barrel spoils all the other apples, and that an apple ripens a green banana if they are put together in a paper bag. Ways to ripen, or spoil, fruit have been known for thousands of years-as the Bible can attest-but now the genes underlying these phenomena of nature have been revealed.

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Three Salk faculty awarded endowed chairs

LA JOLLA, CA—Salk scientists Beverly M. Emerson, Christopher R. Kintner, and Paul E. Sawchenko were selected as inaugural holders of new endowed chairs created through the Joan Klein Jacobs and Irwin Mark Jacobs Senior Scientist Endowed Chair Challenge. In 2008, Dr. and Mrs. Jacobs created a challenge grant to establish endowed chairs for senior scientists. For every $2 million that a donor contributes toward an endowed chair at the Institute, the Jacobses will add $1 million to achieve the $3 million funding level required to fully endow a chair for a Salk senior scientist. To date, 17 out of 20 chairs have been established.

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Protein preps cells to survive stress of cancer growth and chemotherapy

LA JOLLA, CA—Scientists have uncovered a survival mechanism that occurs in breast cells that have just turned premalignant-cells on the cusp between normalcy and cancers-which may lead to new methods of stopping tumors.

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Timing of cancer radiation therapy may minimize hair loss, researchers say

LA JOLLA, CA—Discovering that mouse hair has a circadian clock - a 24-hour cycle of growth followed by restorative repair - researchers suspect that hair loss in humans from toxic cancer radiotherapy and chemotherapy might be minimized if these treatments are given late in the day.

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Salk scientists develop drug that slows Alzheimer's in mice

LA JOLLA, CA—A drug developed by scientists at the Salk Institute for Biological Studies, known as J147, reverses memory deficits and slows Alzheimer's disease in aged mice following short-term treatment. The findings, published May 14 in the journal Alzheimer's Research and Therapy, may pave the way to a new treatment for Alzheimer's disease in humans.

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Salk researchers chart epigenomics of stem cells that mimic early human development

LA JOLLA, CA—Scientists have long known that control mechanisms known collectively as "epigenetics" play a critical role in human development, but they did not know precisely how alterations in this extra layer of biochemical instructions in DNA contribute to development.

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Salk scientists find potential therapeutic target for Cushing's disease

LA JOLLA, CA—Scientists at the Salk Institute for Biological Studies have identified a protein that drives the formation of pituitary tumors in Cushing's disease, a development that may give clinicians a therapeutic target to treat this potentially life-threatening disorder.

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Smoke signals: How burning plants tell seeds to rise from the ashes

LA JOLLA, CA—In the spring following a forest fire, trees that survived the blaze explode in new growth and plants sprout in abundance from the scorched earth. For centuries, it was a mystery how seeds, some long dormant in the soil, knew to push through the ashes to regenerate the burned forest.

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