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Normal chromosome ends elicit a limited DNA damage response

La Jolla, CA – Researchers at the Salk Institute for Biological Studies discovered that cells co-opted the machinery that usually repairs broken strands of DNA to protect the integrity of chromosomes. This finding solves for the first time an important question that has long puzzled scientists.

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3-D structure of Alzheimer's disease filament shows how it zips up peptides

La Jolla, CA – Researchers have solved the three dimensional structure of the long thread-like fibers that fill the brains of Alzheimer's disease patients. The structure reveals the proteins that make up the fibrils lock onto each other much like a zipper on a jacket. This advance, reported in the Nov. 14th early online edition of Proceedings of the National Academy of Sciences (PNAS), helps illuminate the molecular roots of Alzheimer's and possibly other degenerative diseases of the brain.

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Unexpected function for a key regulator of blood glucose levels

La Jolla, CA – An unexpected twist to a discovery reported just two months ago may significantly improve our understanding about the molecular origins of diabetes.

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Inaugural Salk Medals will honor leaders for improving health care of Haitian poor and cancer therapy worldwide

La Jolla, CA – As part of its anniversary celebrations, the Salk Institute for Biological Studies will honor on Nov. 12, two individuals whose life work has taken very different approaches to helping humanity.

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Salk Institute plant biologist named AAAS Fellow

La Jolla, CA – Salk Institute molecular biologist Joanne Chory, Ph.D., an expert on how plants regulate their growth, has been elected a Fellow of the world's largest general scientific society, the American Association for the Advancement of Science (AAAS).

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Salk scientist awarded Glenn T. Seaborg Medal

La Jolla, CA – Ronald M. Evans, Ph.D., who during his 27 years of research at the Salk Institute has made major discoveries about how hormones and drugs control the body's metabolism, development and reproduction, has been honored with the prestigious Glenn T. Seaborg Medal, named for the Nobel laureate chemist who was an advisor to 10 U.S. Presidents.

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Wnt signaling controls the fate of stem cells in adult brains

La Jolla, CA – Scientists at the Salk Institute for Biological Studies have identified a crucial cellular signal that controls the fate of stem cells in the brains of adult mice.

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A genome wide search for genes underlying anxiety disorders turned up unexpected candidates

La Jolla, CA – Increasing the activity of two enzymes better known for their role in oxidative stress metabolism turns normally relaxed mice into 'Nervous Nellies,' according to research conducted at the Salk Institute for Biological Studies and reported in the early online edition of Nature.

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Your brain cells may 'know' more than you let on by your behavior

La Jolla, CA – We often make unwise choices although we should know better. Thunderstorm clouds ominously darken the horizon. We nonetheless go out without an umbrella because we are distracted and forget. But do we? Neurobiologists at the Salk Institute for Biological Studies carried out experiments that prove for the first time that the brain remembers, even if we don't and the umbrella stays behind. They report their findings in the Oct. 20th issue of Neuron.

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Brain's response to visual stimuli shaped by interaction of inhibitory and excitatory neurons, helping us to focus on what we should see, rather than all there is to see

La Jolla, CA – Delving ever deeper into the intricate architecture of the brain, researchers at The Salk Institute have now described how two different types of nerve cells, called neurons, work together in tiny sub-networks to pass on just the right amount and the right kind of sensory information.

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