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Genetically modified mice are resistant to obesity despite a high fat diet

La Jolla, CA – Ravenous mice that chomp down as if there were no tomorrow yet stay lean and mean? Shutting down two genes that modulate a body's energy balance transformed these animals into fidgeting, highly efficient fat burning machines, report scientists at the Salk Institute for Biological Studies in this week's issue of Cell Metabolism.


We live in the past and our brain makes up for it

La Jolla, CA – For the first time, scientists have caught a glimpse of the brain as it predicted the future location of a fast moving object in real time.


Ohio civic volunteer Caryl Philips and former publisher and Santa Barbara resident Michael Pulitzer join Salk Institute?s Board of Trustees

La Jolla, CA – Caryl D. Philips, a longtime supporter of graduate student training at the Salk Institute for Biological Studies in La Jolla, Calif., and Michael Pulitzer, former chairman of a newspaper empire, recently were elected to the Institute's Board of Trustees.


Salk Institute's new faculty scientist conducts basic research on molecular pathways at intersection of diabetes and cancer

La Jolla, CA – A research scientist who recently discovered a critical message-relaying pathway that underlies the development of both cancer and type 2 diabetes, in January joined the Salk Institute for Biological Studies as an assistant professor in the institute's Molecular and Cell Biology Laboratory and Dulbecco Laboratory for Cancer Research.


Human embryonic stem cells integrate successfully into mouse brain

La Jolla, CA – Previous studies have shown that undifferentiated human embryonic stem cells (hESC) can survive in the brains of laboratory rats with Parkinson's disease. But until now it was unclear whether hESCs can become fully functional members of the host animal's neuronal architecture – a basic necessity if stem cells are ever to be used in medical treatments replenishing missing or damaged neurons in human patients with neurodegenerative diseases such as Parkinson's or Alzheimer's disease.


Normal chromosome ends elicit a limited DNA damage response

La Jolla, CA – Researchers at the Salk Institute for Biological Studies discovered that cells co-opted the machinery that usually repairs broken strands of DNA to protect the integrity of chromosomes. This finding solves for the first time an important question that has long puzzled scientists.


3-D structure of Alzheimer's disease filament shows how it zips up peptides

La Jolla, CA – Researchers have solved the three dimensional structure of the long thread-like fibers that fill the brains of Alzheimer's disease patients. The structure reveals the proteins that make up the fibrils lock onto each other much like a zipper on a jacket. This advance, reported in the Nov. 14th early online edition of Proceedings of the National Academy of Sciences (PNAS), helps illuminate the molecular roots of Alzheimer's and possibly other degenerative diseases of the brain.


Unexpected function for a key regulator of blood glucose levels

La Jolla, CA – An unexpected twist to a discovery reported just two months ago may significantly improve our understanding about the molecular origins of diabetes.


Inaugural Salk Medals will honor leaders for improving health care of Haitian poor and cancer therapy worldwide

La Jolla, CA – As part of its anniversary celebrations, the Salk Institute for Biological Studies will honor on Nov. 12, two individuals whose life work has taken very different approaches to helping humanity.


Salk Institute plant biologist named AAAS Fellow

La Jolla, CA – Salk Institute molecular biologist Joanne Chory, Ph.D., an expert on how plants regulate their growth, has been elected a Fellow of the world's largest general scientific society, the American Association for the Advancement of Science (AAAS).


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