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Neurons that detect motion rapidly switch between modes of data collection

La Jolla, CA – Form does follow function, as far as visual cortex neurons tasked with perceiving action are concerned. Far from being the static nerve cells researchers believed them to be, capable of performing only a single function, scientists at the Salk Institute for Biological Studies found these neurons rapidly shift back and forth between two ways of collecting information about moving objects.

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Deconstructing brain wiring, one neuron at a time

La Jolla, CA – Researchers have long said they won't be able to understand the brain until they can put together a "wiring diagram" – a map of how billions of neurons are interconnected. Now, researchers at the Salk Institute for Biological Studies have jumped what many believe to be a major hurdle to preparing that chart: identifying all of the connections to a single neuron.

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DNA ends: common tool, different job

La Jolla, CA – Every time a cell repairs or replicates its DNA, the resulting single strand is wrapped up by a dedicated protein complex. In eukaryotes or organisms whose cells have a nucleus, this job is handled by a tripartite complex called replication protein A (RPA). Researchers at the Salk Institute for Biological Studies have now unearthed a novel RPA-like complex that specifically homes in on the short single-stranded DNA "tail" end of yeast chromosomes.

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FISH-ing for links between cancer and aging

La Jolla, CA – Wielding a palette of chromosome paints, scientists at the Salk Institute for Biological Studies have taken a step closer to understanding the relationship between aging and cancer by visualizing chromosomes of cells from patients with a heritable premature aging disease known as Werner Syndrome.

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Beyond nature vs. nurture: Williams syndrome across cultures

La Jolla, CA – Nobody questions that the color of our eyes is encoded in our genes. When it comes to behavior the concept of "DNA as fate" quickly breaks down – it's been long accepted that both genes and the environment shape human behavior. But just how much sway the environment holds over our genetic destiny has been difficult to untangle.

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National Academy of Sciences honors Joe Ecker with Carty Award

La Jolla, CA – The National Academy of Sciences has selected Joseph R. Ecker, professor in the Plant Biology Laboratory and director of the Salk Institute Genomic Analysis Laboratory, to receive the 2007 John J. Carty Award for the Advancement of Science "for contributions in the areas of ethylene signal transduction and Arabidopsis genomics that have paved the way for a revolution in modern agriculture."

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The time it takes to reassemble the world

La Jolla, CA – A few glimpses are enough to perceive a seamless and richly detailed visual world. But instead of "photographic snapshots," information about the color, shape and motion of an object is pulled apart and sent through individual nerve cells, or neurons, to the visual center in the brain. How the brain puts the scene back to together has been hotly debated ever since neurons were discovered over a century ago.

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Detailed 3-D image catches a key regulator of neural stem cell differentiation in action

La Jolla, CA – Researchers at the Salk Institute for Biological Studies in collaboration with scientists at the University of California, San Diego (UCSD) took a high resolution "action shot" of a protein switch that plays a crucial role in the development of the nervous system. Their findings, published in the Dec. 8 issue of the journal Molecular Cell, provide a template for the design of small molecule inhibitors to control that switch, a protein called Scp1, at will.

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Salk scientist wins 2007 McKnight Neuroscience of Brain Disorders Award

La Jolla, CA —Dr. Andrew Dillin, an assistant professor in the Molecular and Cellular Biology Laboratory at the Salk Institute for Biological Studies, has been selected for the 2007 McKnight Neuroscience of Brain Disorders Award. He will receive $300,000 over a three-year period to study “age-associated neuroprotection by insulin/IGF-1 signaling.”

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Salk scientists named 2006 AAAS Fellows

La Jolla, CA – Professors Terrence J. Sejnowski and Inder Verma have been awarded the distinction of AAAS Fellow. Election as a Fellow of the American Association for the Advancement of Science is an honor bestowed upon members by their peers.

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