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Regulator of lipid metabolism ensures high quality breast milk

La Jolla, CA – Mouse mammary glands deficient in PPARγ, a nuclear receptor that regulates the storage of fat, produce toxic milk that causes inflammation and baldness in suckling pups, report scientists at the Salk Institute for Biological Studies.

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Charting ever-changing genomes

La Jolla, CA – Instead of immutable proprietary software, any species' genetic information resembles open source code that is constantly tweaked and optimized to meet the users' specific needs. But which parts of the code have withstood the test of time and which parts have undergone rapid evolutionary change has been difficult to assess.

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Longtime Salk Researcher Marguerite Vogt Dies

La Jolla, CA – Salk scientist Marguerite Vogt, M.D., long regarded as one of science's greatest unsung female researchers, died today. She was 94 years old.

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Longtime Salk Researcher Marguerite Vogt Dies

La Jolla, CA – Salk scientist Marguerite Vogt, M.D., long regarded as one of science's greatest unsung female researchers, died today. She was 94 years old.

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From the corner of the eye: Paying attention to attention

La Jolla, CA – Every kid knows that moms have "eyes in the back of their heads." We are adept at fixing our gaze on one object while independently directing attention to others. Salk Institute neurobiologists are beginning to tease apart the complex brain networks that enable humans and other higher mammals to achieve this feat.

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Doing nature one better: Expanding the genetic code in living mammalian cells

La Jolla, CA – Researchers at the Salk Institute for Biological Studies have developed a novel strategy to expand the natural repertoire of 20 amino acids in mammalian cells, including neurons, and successfully inserted tailor-made amino acids into proteins in these cells. In a powerful demonstration of the method's versatility, they then used unnatural amino acids to determine the operating mechanism of the "molecular gates" that regulate the movement of potassium ions in and out of nerve cells.

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Doing nature one better: Expanding the genetic code in living mammalian cells

La Jolla, CA – Researchers at the Salk Institute for Biological Studies have developed a novel strategy to expand the natural repertoire of 20 amino acids in mammalian cells, including neurons, and successfully inserted tailor-made amino acids into proteins in these cells. In a powerful demonstration of the method's versatility, they then used unnatural amino acids to determine the operating mechanism of the "molecular gates" that regulate the movement of potassium ions in and out of nerve cells.

read more >>



A possible mechanistic link between stress and the development of Alzheimer tangles

La Jolla, CA – Subjecting mice to repeated emotional stress, the kind we experience in everyday life, may contribute to the accumulation of neurofibrillary tangles, one of the hallmarks of Alzheimer's disease, report researchers at the Salk Institute for Biological Studies. While aging is still the greatest risk factor for Alzheimer's disease, a number of studies have pointed to stress as a contributing factor.

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Cancer stem cells can go it alone

La Jolla, CA – At the heart of most, if not all cancers, lie a handful of wayward stem cells that feed the ever growing tumor mass, but their scarcity make it difficult for scientists to study them. Now, times of plenty may lie ahead as a breast cancer cell line – established long ago – turned out to behave a lot like cancer stem cells.

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Salk Institute receives a $2.3 million stem cell research facility grant

La Jolla, CA – The Salk Institute for Biological Studies was awarded a $2.3 million share of the stem cell research facilities grants approved by the governing board of the California Institute for Regenerative Medicine (CIRM) on June 5.

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