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Molecular "trip switch" shuts down inflammatory response

La Jolla, CA – Like a circuit breaker that prevents electrical wiring from overheating and bringing down the house, a tiny family of three molecules stops the immune system from mounting an out-of-control, destructive inflammatory response against invading pathogens, researchers at the Salk Institute for Biological Studies have found.

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Salk stem cell researchers receive New Faculty Awards

La Jolla, CA – Salk scientists Leanne Jones and Lei Wang today were awarded New Faculty Awards totaling 5.3 million by the governing board of the California Institute for Regenerative Medicine (CIRM). The funds will be split between both researchers over the next five years.

The New Faculty Awards are designed to encourage and foster the next generation of stem cell scientists in the critical early stages of their careers by supporting research across the full range of stem cell types – human and animal, adult and embryonic.

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New chimeric mouse model for human liver diseases, drug testing

La Jolla, CA – Cells cultured in the lab are like a fish out of water. Often, their behavior does not reflect their biological function within an entire organ or organism, which, for example, turns studying human liver cells into a big challenge.

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Salk scientist wins 2007 McKnight Neuroscience of Brain Disorders Award

La Jolla, CA – Dr. Andrew Dillin, an assistant professor in the Molecular and Cellular Biology Laboratory at the Salk Institute for Biological Studies, has been selected for the 2007 McKnight Neuroscience of Brain Disorders Award. He will receive $300,000 over a three-year period to study "age-associated neuroprotection by insulin/IGF-1 signaling."

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A mutation named Magellan steers nerve cells off course

La Jolla, CA – Newly launched nerve cells in a growing embryo must chart their course to distant destinations, and many of the means they use to navigate have yet to surface. In a study published in the current issue of the journal Neuron, scientists at the Salk Institute for Biological Studies have recovered a key signal that guides motor neurons – the nascent cells that extend from the spinal cord and must find their way down the length of limbs such as arms, wings and legs.

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Three Salk scientists named 2007 AAAS Fellows

LA JOLLA, CA—Professors Ursula Bellugi, Walter Eckhart and Greg E. Lemke have been awarded the distinction of AAAS Fellow, an honor that is bestowed upon members of the American Association for the Advancement of Science by their peers.

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Salk Chemical Evolution Scientist Leslie Orgel Dies

La Jolla, CA – Salk scientist Leslie Orgel, Ph.D., who dedicated much of his career to the study of how life began on Earth roughly 4 billion years ago, died on October 27 from pancreatic cancer. He was 80 years old.

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Get in Touch First

La Jolla, CA – When the genetic material inside a cell's nucleus starts to fall apart, a protein called ATM takes charge and orchestrates the rescue mission. Surprisingly, for ATM to kick into full gear, the stretches of DNA flanking a chromosomal break are just as important as the damaged site itself, report scientists at the Salk Institute for Biological Studies.

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Salk scientist receives 2007 Krieg Cortical Discoverer Prize

La Jolla, CA – The Cajal Club has selected Dennis O'Leary, professor in the Molecular Neurobiology Laboratory, to receive the 2007 Krieg Cortical Discoverer Prize for his outstanding research on the mechanisms guiding the functional organization of the cerebral cortex, the brain's powerful central processing unit responsible for higher brain functions.

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Neighborly care keeps stem cells young

La Jolla, CA – A stem cells' immediate neighborhood, a specialized environment also known as the stem cell niche, provides crucial support needed for stem cell maintenance. But nothing lasts forever, found scientists at the Salk Institute for Biological Studies. During the aging process, the level of support drops off, diminishing the stem cells' ability to replenish themselves (self-renew) indefinitely.

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