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Feeding the clock

LA JOLLA, CA—When you eat may be just as vital to your health as what you eat, found researchers at the Salk Institute for Biological Studies. Their experiments in mice revealed that the daily waxing and waning of thousands of genes in the liver—the body's metabolic clearinghouse—is mostly controlled by food intake and not by the body's circadian clock as conventional wisdom had it.


Salk Institute Board of Trustees elects leaders in venture capital and publishing to its membership

LA JOLLA, CA—The Board of Trustees of the Salk Institute for Biological Studies unanimously voted to elect three new members during its November 13 meeting in La Jolla.


Salk recruits three top scientists in Immunobiology, Biophotonics and Neuroscience

LA JOLLA, CA—The Salk Institute for Biological Studies has recruited three assistant professors who exemplify the next generation of leading international scientists hired to forge new research territory and to build on existing investigative areas at the Institute.


Salk technology at the heart of gene therapy success

LA JOLLA, CA—Using a gene therapy delivery system developed in the laboratory of Inder Verma at the Salk Institute for Biological Studies, an international team of researchers successfully treated two children with adrenoleukodystrophy or ALD, in which the fatty insulation of nerve cells degenerates. The genetic disorder leads to progressive brain damage and results in death within two to five years after diagnosis.


Unraveling the mechanisms behind organ regeneration in zebrafish

LA JOLLA, CA—The search for the holy grail of regenerative medicine—the ability to "grow back" a perfect body part when one is lost to injury or disease—has been under way for years, yet the steps involved in this seemingly magic process are still poorly understood.


Salk Institute scientist receives $15.6 million CIRM Disease Team Award to develop novel stem-cell derived therapy for Lou Gehrig's Disease

LA JOLLA—The Salk Institute has been awarded a $10.8 million grant by the California Institute for Regenerative Medicine (CIRM) for translational research focusing on developing a novel stem-cell based therapy for Amyotrophic Lateral Sclerosis (ALS) – or Lou Gehrig's Disease.


Salk scientist receives The Sontag Foundation's Distinguished Scientist Award

LA JOLLA, CA—Dr. Clodagh O'Shea, an assistant professor in the Molecular Cell and Biology Laboratory, has been selected by The Sontag Foundation to receive the 2009 Distinguished Scientist Award. She will receive $600,000 over a four-year period to develop new viral therapies to treat invariably fatal glioblastomas and other brain tumors.


Salk scientist has been elected a member of the European Molecular Biology Organization

LA JOLLA, CA—Dr. Fred H. Gage, a professor in the Laboratory for Genetics at the Salk Institute and the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Diseases, is one of only three Americans elected an Associate Member to the European Molecular Biology Organization (EMBO) in 2009.


The food-energy cellular connection revealed: Metabolic master switch sets the biological clock in body tissues

LA JOLLA, CA—Our body's activity levels fall and rise to the beat of our internal drums-the 24-hour cycles that govern fundamental physiological functions, from sleeping and feeding patterns to the energy available to our cells. Whereas the master clock in the brain is set by light, the pacemakers in peripheral organs are set by food availability. The underlying molecular mechanism was unknown.


What drives our genes? Salk researchers map the first complete human epigenome

LA JOLLA, CA—Although the human genome sequence faithfully lists (almost) every single DNA base of the roughly 3 billion bases that make up a human genome, it doesn't tell biologists much about how its function is regulated. Now, researchers at the Salk Institute provide the first detailed map of the human epigenome, the layer of genetic control beyond the regulation inherent in the sequence of the genes themselves.


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