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From feast to famine: A metabolic switch that may help diabetes treatment

LA JOLLA, CA—Humans are built to hunger for fat, packing it on during times of feast and burning it during periods of famine. But when deluged by foods rich in fat and sugar, the modern waistline often far exceeds the need to store energy for lean times, and the result has been an epidemic of diabetes, heart disease and other obesity-related problems.

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Salk scientist elected to American Academy of Arts and Sciences

LA JOLLA, CA—Salk researcher Edward M. Callaway, a professor in the Systems Neurobiology Laboratories has been elected a Fellow of the American Academy of Arts and Sciences. Dr. Callaway shares the honor with some of the world's most accomplished leaders from academia, business, public affairs, the humanities, and the arts.

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Salk scientists discover how plants grow to escape shade

LA JOLLA, CA—Mild mannered though they seem, plants are extremely competitive, especially when it comes to getting their fair share of sunlight. Whether a forest or a farm, where plants grow a battle rages for the sun's rays.

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Qualcomm donates $1.5 million to Salk in honor of trucking pioneer

LA JOLLA, CA—In memory of Don Schneider, former president, CEO and chairman of Schneider National, Qualcomm has donated $1.5 million to establish the Don Schneider Qualcomm Innovation Fellowship at the Salk Institute. The fellowship will endow a postdoctoral position in Schneider's name in perpetuity and enable the Salk Institute to continue hiring the world's best scientists to conduct biological research that impacts humanity.

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Sugar production switch in liver may offer target for new diabetes therapies

LA JOLLA, CA—In their extraordinary quest to decode human metabolism, researchers at the Salk Institute for Biological Studies have discovered a pair of molecules that regulates the liver's production of glucose—the simple sugar that is the source of energy in human cells and the central player in diabetes.

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Salk scientists redraw the blueprint of the body's biological clock

LA JOLLA, CA—The discovery of a major gear in the biological clock that tells the body when to sleep and metabolize food may lead to new drugs to treat sleep problems and metabolic disorders, including diabetes.

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Salk Institute announces faculty promotions

LA JOLLA, CA—Faculty members Reuben Shaw and Lei Wang, have been promoted to the position of Associate Professor at the Salk Institute after a rigorous evaluation process by Salk senior faculty, Non-Resident Fellows, and scientific peers. The career milestone distinguishes these two investigators as leading authorities in their respective disciplines who have made original, innovative and notable contributions to biological research.

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Prestigious endowed chairs awarded to Salk scientists

The Salk Institute is pleased to announce that faculty members Geoffrey M. Wahl and Martyn Goulding were celebrated as the recipients of endowed chairs in recognition of their significant scientific accomplishments at a special reception on March 29. Joseph Ecker, professor in Salk's Plant Molecular and Cellular Biology Laboratory, who was named holder of the International Council Chair in Genetics in September 2011, was also honored at the ceremony.

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Salk scientists open new window into how cancers override cellular growth controls

LA JOLLA, CA—Rapidly dividing cancer cells are skilled at patching up damage that would stop normal cells in their tracks, including wear and tear of telomeres, the protective caps at the end of each chromosome.

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Sending out an SOS: How telomeres incriminate cells that can't divide

LA JOLLA, CA—The well-being of living cells requires specialized squads of proteins that maintain order. Degraders chew up worn-out proteins, recyclers wrap up damaged organelles, and-most importantly-DNA repair crews restitch anything that resembles a broken chromosome. If repair is impossible, the crew foreman calls in executioners to annihilate a cell. As unsavory as this last bunch sounds, failure to summon them is one aspect of what makes a cancer cell a cancer cell.

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