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William Brody to retire as Salk Institute President

LA JOLLA–William R. Brody will retire from the Salk Institute on December 31, 2015, having led the Institute through a successful fundraising campaign and launching a number of initiatives to ensure that Salk researchers continue to push the boundaries of science and medicine.

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20th Annual Symphony at Salk features jazz sensations Chris Botti and John Pizzarelli

LA JOLLA–The Salk Institute will celebrate 20 years of Symphony at Salk on Saturday, August 29 with a magical evening of jazz. Trumpeter Chris Botti and jazz guitarist John Pizzarelli will join the acclaimed San Diego Symphony, led by distinguished conductor Maestro Thomas Wilkins.

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Brain-based algorithms make for better networks

LA JOLLA–When it comes to developing efficient, robust networks, the brain may often know best. Researchers from the Salk Institute for Biological Studies and Carnegie Mellon University have, for the first time, determined the rate at which the developing brain eliminates unneeded connections between neurons during early childhood.

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Stem cells move one step closer to cure for genetic diseases

LA JOLLA–Healthy brain, muscle, eye and heart cells would improve the lives of tens of thousands of people around the world with debilitating mitochondrial diseases. Now, researchers at the Salk Institute have gotten one step closer to making such cures a reality: they’ve turned cells from patients into healthy, mutation-free stem cells that can then become any cell type. The new approach is described July 15, 2015 in Nature.

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Rusty Gage receives Allen Distinguished Investigator Award to reveal biology of Alzheimer’s disease

LA JOLLA–The Salk Institute today announced that Rusty Gage, Salk professor in the Laboratory of Genetics, has been selected as one of five recipients of the Paul G. Allen Family Foundation’s Allen Distinguished Investigator (ADI) program and will be awarded $1.5 million to conduct his research. These researchers have projects aimed at uncovering the elusive biological foundations of Alzheimer’s disease. The projects are funded at a total of $7 million over three years.

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Salk plant biologist Julie Law named Rita Allen Foundation Scholar

LA JOLLA—Salk Institute plant biologist Julie Law has been named a Rita Allen Foundation Scholar, a distinction given to biomedical scientists whose research holds exceptional promise for advancing the frontiers of knowledge about how biological systems function in health and disease.

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New technique maps elusive chemical markers on proteins

LA JOLLA–Unveiling how the 20,000 or so proteins in the human body work–and malfunction–is the key to understanding much of health and disease. Now, Salk researchers developed a new technique that allows scientists to better understand an elusive step critical in protein formation.

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A high-fat diet may alleviate mitochondrial disease

LA JOLLA–Mice that have a genetic version of mitochondrial disease can easily be mistaken for much older animals by the time they are nine months old: they have thinning grey hair, osteoporosis, poor hearing, infertility, heart problems and have lost weight. Despite having this disease at birth, these mice have a “secret weapon” in their youth that staves off signs of aging for a time.

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New drug squashes cancer's last-ditch efforts to survive

LA JOLLA–As a tumor grows, its cancerous cells ramp up an energy-harvesting process to support its hasty development. This process, called autophagy, is normally used by a cell to recycle damaged organelles and proteins, but is also co-opted by cancer cells to meet their increased energy and metabolic demands.

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Targeting telomeres, the timekeepers of cells, could improve chemotherapy

LA JOLLA–Telomeres, specialized ends of our chromosomes that dictate how long cells can continue to duplicate themselves, have long been studied for their links to the aging process and cancer. Now, a discovery at the Salk Institute shows that telomeres may be more central than previously thought to a self-destruct program in cells that prevents tumors, a function that could potentially be exploited to improve cancer therapies.

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