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Wahl Lab - Current Publications

Wade, M., and Wahl, G.M. (2006) C-myc, genome instability, and tumorigenesis: the devil is in the details. Curr. Top. in Microbiol. and Immunol. 302:169-203. [PDF]
Wahl, G.M. (2006) Mouse bites dogma: how mouse models are changing our views of how p53 is regulated in vivo. Cell Death and Differention 13:973-983. [PDF]
Toledo, F. and Wahl, G.M. (2006) Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Canc. 6:909-923. [PDF]
Wade, M., Wong, E.T., Tang, M., Stommel, J.M. and Wahl, G.M. (2006) Hdmx modulates the outcome of p53 activation in human tumor cells. J Biol. Chem. 281(44):33036-33044. [PDF]
Toledo, F., Lee, C.J., Krummel, K.A., Liu, C.W., Rodewald, L.W., and Wahl, G.M. (2007) Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression. Mol Cell Biol. 27(4):1425–1432. doi: 10.1128/MCB.00999-06. [PDF]
Toledo, F. and Wahl, G.M. (2007) MDM2 and MDM4: p53 regulators as targets in anticancer therapy. International J Bio. & Cell Biol. 39:1476-1482. [PDF]
Wang, Y.V., Wade, M., Wong, E.T., Li, Y-C., Rodewald, L.W., and Wahl, G.M. (2007) Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc. Natl. Acad. Sci. Published online before print July 17, 2007, 10.1073/pnas.0701497104. [PDF]
Wade, M., Rodewald, L.W., Espinosa, J.M., and Wahl, G.M. (2008) BH3 activation blocks Hdmx suppression of apoptosis and co-operates With Nutlin to induce cell death. Cell Cycle. 1:7(13):1973-82. [PDF]
Wade, M., and Wahl, G.M. (2009). Targeting mdm2 and mdmx in cancer: better living through medicinal chemistry? Mol Cancer Res 7(1): 1-11. [PDF]