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Wahl Lab - Publications 2004-2006

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  1. Stommel, J. and Wahl, G.M. (2004) Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation.  EMBO Journal. 23:1547-1556. [PDF]
  2. Thompson, T., Tovar, C., Yang, H., Carvajal, D., Vu, B.T., Xu, Q., Wahl, G.M., Heimbrook, D.C., and Vassilev, L.T. (2004) Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis.  J Biol. Chem. 279(51):53015-53022. [PDF]
  3. Yamamoto, N., Jiang, P., Yang, M., Xu, M., Yamacuhi, K., Tsuchiya, H., Tomita, K., Wahl, G.M., Moossa, A.R., and Hoffman, R.M. (2004) Cellular dynamics visualized in Live Cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res. 64(12):4251-4256. [PDF]
  4. Wahl, G.M., Stommel, J.M., Krummel, K.A., and Wade, M. (2005) Gatekeepers of the guardian: p53 regulation by post-translational modification, Mdm2 and Mdmx. "25 Years of p53 Research". Editors: Klas Wiman and Pierre Hainaut. Publisher: Springer. Chapter 4:73-113. Printed in the Netherlands. [PDF]
  5. Nistér, M., Tang, M. , Zhang, X-Q., Yin, C., Beeche, M., Hu, X., Enblad, G., Van Dyke, T., and Wahl, G.M. (2005) p53 must be competent for transcriptional regulation to suppress tumor formation. Oncogene 24:3563-3573. [PDF]
  6. Stommel, J., and Wahl, G.M. (2005) A new twist in the feedback loop: stress-activated MDM2 destabilization is required for p53 activation. (Invited Chapter). Cell Cycle 4(3):411-417. [PDF]
  7. Krummel, K.A., Toledo, F., Lee, C.J., and Wahl, G.M. (2005) The C-terminal lysines fine-tune p53 stress responses in a mouse model, but are not required for stability control or transactivation. Proc. Natl. Acad. Sci. 102:10188-10193. [PDF]
  8. Wong, E-T., Kolman, J.L., Li, Y-C., and Wahl, G.M. (2005) Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange.  Nucleic Acid Res. 33(17):e147 [PDF]
  9. Buzina A., M. Aladjem, J. Kolman, G. Wahl and J. Ellis. (2005) Initiation of DNA replication at the human b-globin 3' enhancer.  Nucleic Acids Res. 33(14):4412-4424. [PDF]
  10. Clarke, M.F., Dick, J.E. Dirks, P.B. Eaves, C.J. Jamieson, C.H. Jones, D.L., Visvader, J., Weissman, I.L. and Wahl, G.M. (2006) Cancer stem cells--perspectives on current Status and future directions: AACR workshop on cancer stem cells. Cancer Res. 66(19):9339-44. [PDF]
  11. Tang, M., Wahl, G.M. and Nister, M. (2006) Explaining the biological activity of transactivation-deficient p53 variants.  Nat Genet. 38(4):395-6. [PDF]
  12. Marine, J.C. Francoz, S., Maetens, M., Wahl, G.W., Toledo, F. and Lozano, G. (2006) Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death and Differentiation 13:927–934. doi:10.1038/sj.cdd.4401912. [PDF]
  13. Toledo, F., Krummel, K.A., Lee, C.J., Liu, C.W., Rodewald, L.W., Tang, M. and Wahl, G.M. (2006) A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.  Cancer Cell 9:273-85. [PDF]
  14. Burhans, W., Carr, A.M., and Wahl, G.M. (2006) DNA Replication and Cancer. In DNA replication and human disease (ed. M.L. DePamphilis), pp. 481-500. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. [HTML]
  15. Toledo, F., Liu, C.W., Lee, C.J., and Wahl, G.M. (2006) RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses.  Nucleic Acids Research 34(13):e92. [PDF]