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Wahl Lab - Publications 1970-1986

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  1. Evans, D.A., Bryan, C.A. and Wahl, G.M. (l970) Total synthesis of naturally occurring substances. The synthesis of the Hasubanan carbocyclic system. J. Org. Chem. 35: 4l22-4l26.
  2. Sigman, D.S., Wahl, G.M., and Creighton, D.J. (l972) Models for metalloenzymes. Zinc ion catalyzed phosphorylation of l, l0- phenanthroline-2-carbinol by adenosine triphosphates. Biochem. ll:2236- 224l.
  3. Capecchi, M.R., Capecchi, N.E., Hughes, S.H. and Wahl, G.M. (l974) Selective degradation of abnormal proteins in mammalian tissue culture cells. Proc. Nat. Acad. Sci. USA 71: 4732-4736.
  4. Hughes, S.H., Wahl, G.M. and Capecchi, M.R. (l975) Purification and characterization of mouse hypoxanthine-guanine phosphoribosyl transferase. J. Biol. Chem. 250:l20-l26.
  5. Wahl, G.M., Hughes, S.H. and Capecchi, M.R. (l975) Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells:  evidence for mutations at different loci in the HGPRT gene. J. Cell. Physiol. 85:307-320.
  6. Capecchi, M.R., Hughes, S.H. and Wahl, G.M. (l975) Yeast super- suppressors are altered tRNA's capable of translating a nonsense codon in vitro. Cell 6:269-277.
  7. Kohli, J., Kwong, T., Altruda, F., Soll, D. (Yale University), and Wahl, G.M. (University of Utah) (l979) Characterization of a UGA-suppressing serine tRNA from Schizosaccharomyces pombe with the help of a new in vitro assay system for eukaryotic suppressor tRNAs. J. Biol. Chem. 254:l546-l55l.
  8. Padgett, R.A., Wahl, G.M., Coleman, P.F., and Stark, G.R. (l979) N- (phosphonacetyl)-L-aspartate-resistant hamster cells over accumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis. J. Biol. Chem. 254:974-980.
  9. Wahl, G.M., Padgett, R.A., and Stark, G.R. (l979) Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N- (phosphonacetyl)-L- aspartate-resistant hamster cells. J. Biol. Chem. 254:8679-8689.
  10. Wahl, G.M., Stern, M., and Stark, G.R. (l979) Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc. Natl. Acad. Sci. USA 76:3683-3687.
  11. Alwine, J.C., Kemp, D.J., Parker, B.A., Reiser, J., Renart,J., Stark, G.R., and Wahl, G.M. (l979) Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper. Methods in Enzymology 68:220-242.
  12. Kohli, J., Altruda, F., Kwong, T., Rafalski, A., Wetzel, R., Soll, D., Wahl, G.M., and Leupold, U. (l980) Nonsense Suppressor tRNA in Schizosaccharomyces pombe. tRNA:  Biological Aspects, Cold Spring Harbor Quant. Biol. 407-4l9.
  13. Robert de Saint Vincent, B., Delbruck, S., Eckhart, W., Meinkoth, J., Vitto, L., and Wahl, G. (l98l) Cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker. Cell 27:267-277.
  14. Wahl, G.M., Vitto, L., Padgett, R.A., and Stark, G.R. (l982) Single-copy and amplified CAD genes in Syrian hamster chromosomes using a highly sensitive method for in situ hybridization. Mol. Cell. Biol. 2:308-3l9.
  15. Padgett, R.A., Wahl, G.M., and Stark, G.R. (l982) Structure of the gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells. Mol. Cell. Biol. 2:293-30l.
  16. Padgett, R.A., Wahl, G.M., and Stark, G.R. (l982) Properties of dispersed, highly repeated DNA within and near the hamster CAD gene. Mol. Cell. Biol. 2:302-307.
  17. Folger, K.R., Wong, E.A., Wahl, G.M. and Capecchi, M.R. (l982) Patterns of integration of DNA microinjected into cultured mammalian cells:  Evidence for homologous recombination between injected plasmid DNA molecules. Mol. Cell Biol. 2:l372-l387.
  18. Wahl, G.M., Allen, V., Delbruck, S., Eckhart, W., Meinkoth, J., Padgett, R., Robert de Saint Vincent, B., Rubintz, J., Stark, G.R. and Vitto, L. (l982) Analysis of CAD gene amplification using molecular cloning, gene transfer and cytogenetics. In Gene Amplification (R.T. Schimke, ed.) Cold Spring Harbor Laboratory, pp. l67-l75.
  19. Padgett, R.A., Wahl, G.M., Brison, O., and Stark, G.R. (l982) Use of recombinant DNA techniques to examine amplified regions of DNA from drug-resistant mutant cells, p. l09-l3l.  In A.G. Walton (ed.) Third Cleveland Symposium on Macromolecules-Recombinant DNA.  Elsevier Scientific Publishing Co., Amsterdam.
  20. Chu, B.C.F., Wahl, G.M. and Orgel, L.E. (1983) Derivatization of unprotected polynucleotides. Nucl. Acids Res. 11:6513-6529.
  21. Robert de Saint Vincent, B., and Wahl, G.M. (l983) Homologous recombination in mammalian cells mediates the formation of a functional gene from two overlapping gene fragments. Proc. Natl. Acad. Sci. USA 80:2002-2006.
  22. Redfield, D.C., Richman, D.D., Albanil, S., Oxman, M. and Wahl, G.M. (l983) Detection of herpes simplex virus in clinical specimens by DNA hybridization. Diagnostic Micro. and Infectious Dis. l:ll7-l28.
  23. Wahl, G.M., Vitto, L., and Rubnitz, J. (l983) Co-amplification of rRNA genes with CAD genes in N-(Phosphonacetyl)-L-Aspartate-resistant Syrian hamster cells. Mol. Cell. Biol. 3:2066-2075.
  24. Wahl, G.M., Robert de Saint Vincent, B. and De Rose, M.L. (l984) Effect of chromosomal position on amplification of transfected genes in animal cells. Nature 307:516-520.
  25. Richman, D.D., Cleveland,P.H., Redfield, D.C., Oxman, M.N. and Wahl, G.M. (1984) Rapid viral diagnosis. J. Infec. Diseases 149:298-310.
  26. Wahl, G.M., Allen, V., Delbruck, S., Eckhart, W., Meinkoth, J., Robert de Saint Vincent, B., and Vitto, L. (l984) Analysis of CAD gene amplification using a combined approach of molecular genetics and cytogenetics. In "Eukaryotic Cell Cultures: Basics and Applications." Edited by Ronald T. Acton and J. Daniel Lynn, Plenum Press, New York and London. Advances in Experimental Medicine and Biology, Vol. 172:319-345.
  27. Stark, G.R. and Wahl, G.M. (1984) Gene amplification. Ann. Rev. Biochem.  Annual Reviews of Biochemistry 53: 447-491.
  28. Meinkoth, J. and Wahl, G.M. (1984) Hybridization of Nucleic Acids Immobilized on Solid Supports. Analytical Biochemistry 138:267-284.
  29. Wahl, G.M., Albanil, S., Ignacio, K. and Richman, D.D. (1985) Nucleic Acid Hybridization: A Powerful Technology Useful for Medical Diagnosis, pp 31-64. In: Medical Virology IV, de la Maza, L.M. and Peterson, E.M., eds.  Lawrence Erlbaum Associates, Publishers, Hillsdale, New Jersey.
  30. Wahl, G.M. (1985) Detection of Adventitious Agents and Sensitivity of Methods. In: Abnormal Cells, New Products and Risk.  Hopps, H.E. and Petricciani, J.C., eds. Tissue Culture Association, Gaithersburg, Maryland.
  31. Gaudray, P., Trotter, J. and Wahl, G.M. (1986). Fluorescent methotrexate labeling and flow cytometric analysis of cells containing low levels of dihydrofolate reductase. J. Biol. Chem. 261:6285 - 6292.
  32. Meinkoth, J.L., Legouy, E., Brison, O. and Wahl, G.M. (1986) New RNA species is produced by alternate polyadenylation following a rearrangement associated with CAD gene amplification. Som. Cell and Mol. Genet. 12:339-350.
  33. Ruiz, J.C. and Wahl, G.M. (1986) Escherichia coli aspartate transcarbamylase: a novel marker for studies of gene amplification and expression in mammalian cells. Mol. Cell. Biol. 6:3050-3058.