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Slesinger Lab - Recent Publication List

Boyer, S, Slesinger, PA and Jones, SVP (2008) Regulation of Kir2.1 channels by the Rho-GTPase, Rac1 Journal of Cellular Physiology (in press)

Lomazzi, M, Slesinger, PA and Lüscher, C (2008) Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins. Trends in Pharmacological Sciences (in press).

Nassirpour, R, and Slesinger, PA (2007) Subunit-specific regulation of Kir3 channels by sorting nexin 27. Channels 1(5):331-333. <PubMed>

Labouébe, G, Lomazzi, M, Cruz, HG, Creton, C, Luján, R, Li, M, Yanagawa, Y, Obata, K, Watanabe, M, Wickman, K, Boyer, SB, Slesinger, PA and Lüscher, C (2007) RGS2 modulates GABAB receptor-GIRK channel coupling in dopamine neurons of the ventral tegmental area. Nat. Neurosci., 10(12):1559 - 1568 <PDF>

Lunn, ML, Nassirpour, R, Arrabit, C, Tan, J, Mcleod, I, Arias, CM, Sawchenko, PE, Yates, III, JR and Slesinger, PA (2007) A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. Nat. Neurosci., 10(10):1249-1259. <PDF>

Wang, W, Takimoto, JK, Louie, GV, Baiga, TJ, Noel, JP, Lee, KF, Slesinger, PA and Wang, L (2007) Genetically encoding unnatural amino acids for cellular and neuronal studies.  Nat. Neurosci., 10(8):1063-72. <PDF>

Kurata, HT, Cheng, W, Arrabit, C, Slesinger, PA and Nichols, CG (2007) The role of the cytoplasmic pore in inward rectification of Kir2.1 channels J. Gen. Phys., 130(2):145-55. < PDF>

Clancy, SM, Boyer, SB and Slesinger, PA (2007) Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G Protein-activated potassium channels. J. Neurosci., 27(24):6388-99. <PDF>

Pegan, S, Tan, J., Huang, A., Slesinger, P.A., Riek, R. and Choe, S. (2007) NMR Studies of Interactions between C-terminal Tail of Kir2.1 Channel and PDZ1-2 domains of PSD95. Biochemistry, 46(18):5315-22. <PDF>

Fowler, CE., Aryal, P., Suen, KF and Slesinger, PA (2007) Evidence for association of GABAB receptors with Kir3 channels and RGS4 proteins.  J. Physiol., 580(Pt 1):51-65 <PDF>

Pegan, S, Arrabit, C., Slesinger, P.A. and Choe, S. (2006) Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1. Biochemistry, 45:8599-606. <PDF>

Clancy, S.M., Fowler, C., Finley, M., Arrabit, C., Suen, K.-F., Berton, F., Kozasa, T, Casey, P.J. and Slesinger, P.A.  (2005) Pertussis toxin-sensitive Gα subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. Mol. Cell. Neurosci., 28:375-89. <PDF>

Pegan, S., Arrabit, C., Zhou, W, Kwiatkowski, W., Collins, A., Slesinger, P.A. and Choe, S. (2005).  Kir2.1 and Kir3.1 cytoplasmic domain structures reveal sites for modulating gating and rectification. Nature Neurosci., 8:279-87. <PDF>

Mutneja, M., Berton, F., Suen, K.-F., Lüscher, C. and Slesinger, P.A. (2005) Endogenous RGS proteins enhance acute desensitization of GABAB receptor-activated GIRK currents in HEK-293T cells. Pflügers Archiv - Eur. J. Physiol.,450:61-73. <PDF>

Panicker, S, Cruz, H., Arrabit, C., Suen, K.-F and Slesinger, P.A. (2004) Minimal movement in the selectivity filter during gating of the 5-HT3A channel. J. Biol. Chem., 279(27):28149-58. <PDF>

Cruz HG, Ivanova T, Lunn ML, Stoffel M, Slesinger PA, Lüscher C (2004) Bi-directional effects of GABAB receptor agonists on the mesolimbic dopamine system. Nature Neurosci., 7:153-159. <PDF>

Finley, M, Arrabit C, Fowler C, Suen KF, Slesinger PA (2004) bL-bM loop in the C-terminal domain of GIRK channels is important for Gβγ activation. J. Physiol., 555:643-657. <PDF>

Panicker, S, Cruz, H, Arrabit, C and Slesinger, PA (2002) Evidence for a centrally located gate in a serotonin-gated ion channel. J. Neurosci., 22:1629-1639. <PDF>

Zhou, W, Arrabit, C, Choe, S and Slesinger, PA (2001) Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels. Proc. Natl. Acad. Sci. USA 98:6482-6487. <PDF>

Slesinger, PA  (2001) Ion selectivity filter regulates local anesthetic inhibition of G protein-gated inwardly rectifying K+ channels. Biophys. J., 80:707-718. <PDF>