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All Publications

Faubert, B., Vincent, E.E., Griss, T., Samborska, B., Izreig, S., Svensson, R.U., Mamer, O.A., Avizonis, D., Shackelford, D.B., Shaw, R.J. and Jones, R.G. (2014) Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α. Proc Natl Acad Sci USA 111:2554-2559. PMCID: PMC3932920.

Goodwin, J.M., Svensson, R.U., Lou, H.J., Winslow, M.M., Turk, B.E., and Shaw, R.J. (2014). An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential. Mol Cell 55:436-450. PMCID: PMC4151130

Mochiroud, L., Eichner, L.J., Shaw, R. and Auwerx, J. (2014) Transcriptional Coregulators: Fine-Tuning Metabolism. Cell Metab 20:26-40. PMCID: PMC4079747

Chun, M.G. and Shaw, R.J. (2013) Cancer metabolism in breadth and depth. Nat Biotechnol 31:505-507.

Shaw, R.J. (2013) Cell Biology. GATORs Take a Bite Out of mTOR. Science 340:1056-1057.

Mihaylova, M.M. and Shaw, R.J. (2013) Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol Metab 24:48-57.

Shackelford, D.B., Abt, E., Gerken, L., Vasquez, D.S., Atsuko, S., Leblanc, M., Wei, L., Fishbein, M.C., Czernin, J., Mischel, P.S. and Shaw, R.J. (2013) LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell 23:143-158.

Auricchio, N., Malinowska, I., Shaw, R., Manning, B.D., and Kwiatkowski, D.J. (2012). Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). PLoS ONE 7:e31900.

Shaw, R.J. and Cantley, L.C. (2012) Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice. F1000 Biol Rep 4:2.

Shaw, R.J. and Cantley, L.C. (2012) Ancient Sensor for Ancient Drug. Science 336:813-4.

Svensson, R.U. and Shaw, R.J. (2012) Cancer metabolism: Tumour friend or foe. Nature 485:590-591.

Xia, Y., Yeddula, N., LeBlanc, M., Ke, E., Zhang, Y., Oldfield, E., Shaw, R.J. and Verma, I.M. (2012) Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nat Cell Biol 14:257-65.

Akhtar, A., Fuchs, E., Mitchison, T., Shaw, R.J., St. Johnston, D., Strasser, A., Taylor, S., Walczak, C. and Zerial, M. (2011) A decade of molecular cell biology: achievements and challenges. Nat Rev Mol Cell Biol 12:669-674.

Birnbaum, M.J. and Shaw, R.J. (2011) Genomics: Drugs, diabetes, and cancer. Nature 470:338-339.

Egan, D.F., Shackelford, D.B., Mihaylova, M.M., Gelino, S.R., Kohnz, R.A., Mair, W., Vasquez, D.S., Joshi, A., Gwinn, D.M., Taylor, R., Asara, J.M., Fitzpatrick, J., Dillin, A., Viollet, B., Kundu. M., Hansen, M. and Shaw, R.J. (2011) Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy. Science 331:456-461.

Egan, D., Kim, J., Shaw, R.J. and Guan, K.L. (2011) The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. Autophagy 7:643-644.

Li, Y., Xu, S., Mihaylova, M.M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, E., Shyy, J.Y-J., Gao, B., Wierzbicki, M., Verbeuren, T.J., Shaw, R.J., Cohen, R.A. and Zang, M. (2011) AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-induced Insulin Resistant Mice. Cell Metab 13:376-388.

Mair, W., Morantte, I., Rodrigues, A.P., Manning, G., Montminy, M., Shaw*, R.J. and Dillin*, A. (2011) Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature 470: 404-408. [*Corresponding authors]

Mihaylova, M.M. and Shaw, R.J. (2011) The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 13:1016-1023.

Mihaylova, M.M., Vasquez, D.S., Ravnskjaer, K., Denechaud, P-D., Yu, R.T., Alvarez, J.G., Downes, M., Evans, R.M., Montminy, M. and Shaw, R.J. (2011) Class IIa Histone Deacetylases are Hormone-activated regulators of FOXO and Mammalian Glucose Homeostasis. Cell 145:607-621.

Wang, B., Moya, N., Niessen, S., Hoover, H., Mihaylova, M.M., Shaw, R.J., Yates, J.R. 3rd, Fischer, W.H., Thomas, J.B. and Montminy, M. (2011) A hormone-dependent module regulating energy balance. Cell 145:596-606.

Gwinn, D.M. and Shaw, R.J. (2010) AMPK control of mTOR signaling and Growth. The Enzymes, 28:49-75.

Gwinn, D.M., Asara, J. and Shaw, R.J. (2010) Raptor is phosphorylated by cdc2 during mitosis. PLoS ONE 5:e9197.

Ohashi, K., Ouchi, N., Higuchi, A., Shaw, R.J. and Walsh, K. (2010) LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis. J Biol Chem 285:22291-22298.

Shaw, R.J. (2010) Metabolism and cancer mix in Madrid. EMBO Rep 11:249-251.

Shaw, R.J., Evans, R.M. and Simon, M.C. (2010) Metabolism and Cancer in La Jolla. Cancer Res 70:3864-3869.

Ikeda, Y., Sato, K., Pimental, D.R., Sam, F., Shaw, R.J., Dyck, J.R. and Walsh, K. (2009) Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. J Biol Chem 284:35839-35849.

Lamia, K.A., Sachdeva, U.M., DiTacchio, L., Williams, E.C., Alvarez, J.G., Egan, D.F., Vasquez, D.S., Juguilon, H., Panda, S., Shaw, R.J., Thompson, C.B. and Evans, R.M. (2009) AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 326:437-440.

Mair, W., Panowski, S.H., Shaw, R.J. and Dillin, A. (2009) Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS ONE 4:e4535.

Mihaylova, M.M. and Shaw, R.J. (2009) The LKB1-AMPK pathway controls hepatic metabolism and therapeutic response. The Liver, 5th edition, Wiley-Blackwell, pp.535-549.

Shaw, R.J. (2009) LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol 196:65-80.

Shaw, R.J. (2009) Tumor suppression by LKB1: SIK-ness prevents metastasis. Sci Signal 2:pe55.

Shaw, R. and Dillin, A. (2009) PPTR-1 counterAkts insulin signaling. Cell 136:816-818.

Shackelford, D.B. and Shaw, R.J. (2009) The LKB1-AMPK pathway: metabolism and growth control in tumor suppression. Nat Rev Cancer 9:563-575.

Shackelford, D.B., Vasquez, D.S., Corbeil, J., Wu, S., Leblanc, M., Wu, C.-L., Vera, D.R. and Shaw, R.J. (2009) mTOR and HIF-1α mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci USA 106:11137-11142.

Gwinn, D.M., Shackelford, D.B., Egan, D.F., Mihaylova, M.M., Mery, A., Vasquez, D.S., Turk, B.E. and Shaw, R.J. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30:214-226.

Narkar, V.A., Downes, M., Yu, R.T., Embler, E., Wang, Y.X., Banayo, E., Mihaylova, M.M., Nelson, M.C., Zou, Y., Juguilon, H., Kang, H., Shaw, R.J. and Evans, R.M. (2008) AMPK and PPARdelta agonists are exercise mimetics. Cell 134:405-415.

Shaw, R.J. (2008) LKB1: cancer, polarity, metabolism, and now fertility. Biochem J 416:e1-3.

Shaw, R.J. (2008) mTOR signaling: RAG GTPases transmit the amino acid signal. Trends Biochem Sci 33:565-568.

Shaw, R.J. (2008) Raptor swoops in on metabolism. Cell Metabolism. 8:343-344.

Shaw, R.J. and Cantley, L.C. (2008) The PI3K-LKB1 Pathway. Inborn Errors of Development, 2nd edition, pp.273-279.

Shaw, R.J. (2006) Glucose metabolism and cancer. Curr Opin Cell Biol 18:598-608.

Shaw, R.J. and Cantley, L.C. (2006) Ras, PI3(K), and mTOR signaling control tumor cell growth. Nature 441:424-430.

Baur, J.A., Pearson, K.J., Price, N.L., Jamieson, H.A., Lerin, C., Kalra, A., Prabhu, V.V., Allard, J.S., Lopez-Lluch, G., Lewis, K., Pistell, P.J., Poosala, S., Becker, K.G., Boss, O., Gwinn, D., Wang, M., Ramaswamy, S., Fishbein, K.W., Spencer, R.G., Lakatta, E.G., LeCouteur, D., Shaw, R.J., Navas, P., Puigserver, P., Igram, D.K., deCabo, R. and Sinclair, D.A. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337-342.

Fernandes, N., Sun, Y., Chen, S., Paul, P., Shaw, R.J., Cantley, L.C. and Price, B.D. (2005) DNA damage-induced association of ATM with its target proteins requires protein interaction domain in the N terminus of ATM. J Biol Chem 280:15158-15164.

Shaw, R.J., Lamia, K.A., Vasquez, D., Koo, S.H., Bardeesy, N., DePinho, R.A., Montminy, M. and Cantley, L.C. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310:1642-1646.

Shaw, R.J., Kosmatka, M., Bardeesy, N., Hurley, R.L., Witters, L.A., DePinho, R.A. and Cantley, L.C. (2004) Inaugural article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 101:3329-3335.

Shaw, R.J., Bardeesy, N., Manning, B., Lopez, L., Kosmatka, M., DePinho, R.A. and Cantley, L.C. (2004) The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6:91-99.

Shaw, R.J., Paez, J.G., Curto, M., Yaktine, A., Pruitt, W.M., Saotome, I., O’Bryan, J.P., Gupta, V., Ratner, N., Der, C.J., Jacks, T. and McClatchey, A.I. (2001) The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell 1:63-72.

Karuman, P., Gozani, O., Odze, R., Zhou, X.C., Zhu, H., Shaw, R.J., Brien, T.P., Bozzuto, C.D., Ooi, D., Cantley, L.C. and Yuan, J. (2001) The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell 7:1307-1319.

Shaw, R.J., Henry, M., Solomon, F. and Jacks, T. (1998) RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/ actin protrusions in fibroblasts. Mol Biol Cell 9:403-419.

Shaw, R.J., McClatchey, A.I. and Jacks, T. (1998) Regulation of the Neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli. J Biol Chem 273:7757-7764.

Shaw, R.J., McClatchey, A.I. and Jacks, T. (1998) Localization and functional domains of the neurofibromatosis type II tumor suppressor, merlin. Cell Growth Diff 9:287-296.

Platko, J., Leonard, D., Adra, C., Shaw, R.J., Cerione, R.A. and Lim, B. (1995) A single residue can modify target binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors. Proc Natl Acad Sci USA 92:2974-8.



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