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Publications

All Publications

Chun, M.G. and Shaw, R.J. (2013) Cancer metabolism in breadth and depth. Nat Biotechnol 31:505-507.

Shaw, R.J. (2013) Cell Biology. GATORs Take a Bite Out of mTOR. Science 340:1056-1057.

Mihaylova, M.M. and Shaw, R.J. (2013) Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol Metab 24:48-57.

Shackelford, D.B., Abt, E., Gerken, L., Vasquez, D.S., Atsuko, S., Leblanc, M., Wei, L., Fishbein, M.C., Czernin, J., Mischel, P.S. and Shaw, R.J. (2013) LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell 23:143-158.

Auricchio, N., Malinowska, I., Shaw, R., Manning, B.D., and Kwiatkowski, D.J. (2012). Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). PLoS ONE 7:e31900.

Shaw, R.J. and Cantley, L.C. (2012) Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice. F1000 Biol Rep 4:2.

Shaw, R.J. and Cantley, L.C. (2012) Ancient Sensor for Ancient Drug. Science 336:813-4.

Svensson, R.U. and Shaw, R.J. (2012) Cancer metabolism: Tumour friend or foe. Nature 485:590-591.

Xia, Y., Yeddula, N., LeBlanc, M., Ke, E., Zhang, Y., Oldfield, E., Shaw, R.J. and Verma, I.M. (2012) Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nat Cell Biol 14:257-65.

Akhtar, A., Fuchs, E., Mitchison, T., Shaw, R.J., St. Johnston, D., Strasser, A., Taylor, S., Walczak, C. and Zerial, M. (2011) A decade of molecular cell biology: achievements and challenges. Nat Rev Mol Cell Biol 12:669-674.

Birnbaum, M.J. and Shaw, R.J. (2011) Genomics: Drugs, diabetes, and cancer. Nature 470:338-339.

Egan, D.F., Shackelford, D.B., Mihaylova, M.M., Gelino, S.R., Kohnz, R.A., Mair, W., Vasquez, D.S., Joshi, A., Gwinn, D.M., Taylor, R., Asara, J.M., Fitzpatrick, J., Dillin, A., Viollet, B., Kundu. M., Hansen, M. and Shaw, R.J. (2011) Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy. Science 331:456-461.

Egan, D., Kim, J., Shaw, R.J. and Guan, K.L. (2011) The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. Autophagy 7:643-644.

Li, Y., Xu, S., Mihaylova, M.M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, E., Shyy, J.Y-J., Gao, B., Wierzbicki, M., Verbeuren, T.J., Shaw, R.J., Cohen, R.A. and Zang, M. (2011) AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-induced Insulin Resistant Mice. Cell Metab 13:376-388.

Mair, W., Morantte, I., Rodrigues, A.P., Manning, G., Montminy, M., Shaw*, R.J. and Dillin*, A. (2011) Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature 470: 404-408. [*Corresponding authors]

Mihaylova, M.M. and Shaw, R.J. (2011) The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 13:1016-1023.

Mihaylova, M.M., Vasquez, D.S., Ravnskjaer, K., Denechaud, P-D., Yu, R.T., Alvarez, J.G., Downes, M., Evans, R.M., Montminy, M. and Shaw, R.J. (2011) Class IIa Histone Deacetylases are Hormone-activated regulators of FOXO and Mammalian Glucose Homeostasis. Cell 145:607-621.

Wang, B., Moya, N., Niessen, S., Hoover, H., Mihaylova, M.M., Shaw, R.J., Yates, J.R. 3rd, Fischer, W.H., Thomas, J.B. and Montminy, M. (2011) A hormone-dependent module regulating energy balance. Cell 145:596-606.

Gwinn, D.M. and Shaw, R.J. (2010) AMPK control of mTOR signaling and Growth. The Enzymes, 28:49-75.

Gwinn, D.M., Asara, J. and Shaw, R.J. (2010) Raptor is phosphorylated by cdc2 during mitosis. PLoS ONE 5:e9197.

Ohashi, K., Ouchi, N., Higuchi, A., Shaw, R.J. and Walsh, K. (2010) LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis. J Biol Chem 285:22291-22298.

Shaw, R.J. (2010) Metabolism and cancer mix in Madrid. EMBO Rep 11:249-251.

Shaw, R.J., Evans, R.M. and Simon, M.C. (2010) Metabolism and Cancer in La Jolla. Cancer Res 70:3864-3869.

Ikeda, Y., Sato, K., Pimental, D.R., Sam, F., Shaw, R.J., Dyck, J.R. and Walsh, K. (2009) Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. J Biol Chem 284:35839-35849.

Lamia, K.A., Sachdeva, U.M., DiTacchio, L., Williams, E.C., Alvarez, J.G., Egan, D.F., Vasquez, D.S., Juguilon, H., Panda, S., Shaw, R.J., Thompson, C.B. and Evans, R.M. (2009) AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 326:437-440.

Mair, W., Panowski, S.H., Shaw, R.J. and Dillin, A. (2009) Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS ONE 4:e4535.

Mihaylova, M.M. and Shaw, R.J. (2009) The LKB1-AMPK pathway controls hepatic metabolism and therapeutic response. The Liver, 5th edition, Wiley-Blackwell, pp.535-549.

Shaw, R.J. (2009) LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol 196:65-80.

Shaw, R.J. (2009) Tumor suppression by LKB1: SIK-ness prevents metastasis. Sci Signal 2:pe55.

Shaw, R. and Dillin, A. (2009) PPTR-1 counterAkts insulin signaling. Cell 136:816-818.

Shackelford, D.B. and Shaw, R.J. (2009) The LKB1-AMPK pathway: metabolism and growth control in tumor suppression. Nat Rev Cancer 9:563-575.

Shackelford, D.B., Vasquez, D.S., Corbeil, J., Wu, S., Leblanc, M., Wu, C.-L., Vera, D.R. and Shaw, R.J. (2009) mTOR and HIF-1α mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci USA 106:11137-11142.

Gwinn, D.M., Shackelford, D.B., Egan, D.F., Mihaylova, M.M., Mery, A., Vasquez, D.S., Turk, B.E. and Shaw, R.J. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30:214-226.

Narkar, V.A., Downes, M., Yu, R.T., Embler, E., Wang, Y.X., Banayo, E., Mihaylova, M.M., Nelson, M.C., Zou, Y., Juguilon, H., Kang, H., Shaw, R.J. and Evans, R.M. (2008) AMPK and PPARdelta agonists are exercise mimetics. Cell 134:405-415.

Shaw, R.J. (2008) LKB1: cancer, polarity, metabolism, and now fertility. Biochem J 416:e1-3.

Shaw, R.J. (2008) mTOR signaling: RAG GTPases transmit the amino acid signal. Trends Biochem Sci 33:565-568.

Shaw, R.J. (2008) Raptor swoops in on metabolism. Cell Metabolism. 8:343-344.

Shaw, R.J. and Cantley, L.C. (2008) The PI3K-LKB1 Pathway. Inborn Errors of Development, 2nd edition, pp.273-279.

Shaw, R.J. (2006) Glucose metabolism and cancer. Curr Opin Cell Biol 18:598-608.

Shaw, R.J. and Cantley, L.C. (2006) Ras, PI3(K), and mTOR signaling control tumor cell growth. Nature 441:424-430.

Baur, J.A., Pearson, K.J., Price, N.L., Jamieson, H.A., Lerin, C., Kalra, A., Prabhu, V.V., Allard, J.S., Lopez-Lluch, G., Lewis, K., Pistell, P.J., Poosala, S., Becker, K.G., Boss, O., Gwinn, D., Wang, M., Ramaswamy, S., Fishbein, K.W., Spencer, R.G., Lakatta, E.G., LeCouteur, D., Shaw, R.J., Navas, P., Puigserver, P., Igram, D.K., deCabo, R. and Sinclair, D.A. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337-342.

Fernandes, N., Sun, Y., Chen, S., Paul, P., Shaw, R.J., Cantley, L.C. and Price, B.D. (2005) DNA damage-induced association of ATM with its target proteins requires protein interaction domain in the N terminus of ATM. J Biol Chem 280:15158-15164.

Shaw, R.J., Lamia, K.A., Vasquez, D., Koo, S.H., Bardeesy, N., DePinho, R.A., Montminy, M. and Cantley, L.C. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310:1642-1646.

Shaw, R.J., Kosmatka, M., Bardeesy, N., Hurley, R.L., Witters, L.A., DePinho, R.A. and Cantley, L.C. (2004) Inaugural article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 101:3329-3335.

Shaw, R.J., Bardeesy, N., Manning, B., Lopez, L., Kosmatka, M., DePinho, R.A. and Cantley, L.C. (2004) The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6:91-99.

Shaw, R.J., Paez, J.G., Curto, M., Yaktine, A., Pruitt, W.M., Saotome, I., O’Bryan, J.P., Gupta, V., Ratner, N., Der, C.J., Jacks, T. and McClatchey, A.I. (2001) The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell 1:63-72.

Karuman, P., Gozani, O., Odze, R., Zhou, X.C., Zhu, H., Shaw, R.J., Brien, T.P., Bozzuto, C.D., Ooi, D., Cantley, L.C. and Yuan, J. (2001) The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell 7:1307-1319.

Shaw, R.J., Henry, M., Solomon, F. and Jacks, T. (1998) RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/ actin protrusions in fibroblasts. Mol Biol Cell 9:403-419.

Shaw, R.J., McClatchey, A.I. and Jacks, T. (1998) Regulation of the Neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli. J Biol Chem 273:7757-7764.

Shaw, R.J., McClatchey, A.I. and Jacks, T. (1998) Localization and functional domains of the neurofibromatosis type II tumor suppressor, merlin. Cell Growth Diff 9:287-296.

Platko, J., Leonard, D., Adra, C., Shaw, R.J., Cerione, R.A. and Lim, B. (1995) A single residue can modify target binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors. Proc Natl Acad Sci USA 92:2974-8.

 

 

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