O'Shea Lab

Publications

Selected Publications

 

Ou, H.D., Kwiatkowski, W., Deerinck, T.J., Noske, A., Blain, K.Y., Land, H.S., Soria, C., Powers, C.J., May, A.P., Shu, X., Tsien, R.Y., Fitzpatrick, J.A.J., Long, J.A., Ellisman, M.H., Choe, S. and O'Shea, C.C. (2012) A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. Cell 151:304-19.

Ou, H.D., May, A.P. and O’Shea, C.C. (2011) The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication. Wiley Interdiscip Rev Syst Biol Med 3:48-73.

Soria, C., Estermann, F.E., Espantman, K.C. and O’Shea, C.C. (2010) Heterochromatin silencing of p53 target genes by a small viral protein. Nature 466:1076-1081.

Espantman, K.C. and O’Shea, C.C. (2010) aMAGEing new players enter the RING to promote ubiquitylation. Mol Cell 39:835-837.

Iacovides, D., O’Shea, C.C., Oses-Prieto, J., Burlingame, A. and McCormick, F. (2007) Critical role for arginine methylation in adenovirus-infected cells. J Virol 81:13209-13217.

Ringshausen, I., O'Shea, C.C., Finch, A.J., Swigart, L.B. and Evan, G.I. (2006) Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 10:501-514.

O'Shea, C.C. (2005) DNA tumor viruses - the spies who lyse us. Curr Opin Genet Dev 15:18-26.

O'Shea, C.C. (2005) Viruses - seeking and destroying the tumor program. Oncogene 24:7640-7655.

O'Shea, C.C. (2005) Viruses: tools for tumor target discovery and agents for lytic cancer therapies - an introduction. Oncogene 24:7636-7639.

O'Shea, C.C., Choi, S., McCormick, F. and Stokoe, D. (2005) Adenovirus overrides cellular checkpoints for protein translation. Cell Cycle 4:883-888.

O'Shea, C.C. and Fried, M. (2005) Modulation of the ARF-p53 pathway by the small DNA tumor viruses. Cell Cycle 4:449-452.

O'Shea, C.C., Klupsch, K., Choi, S., Bagus, B., Soria, C., Shen, J., McCormick, F. and Stokoe, D. (2005) Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. EMBO J 24:1211-1221.

O'Shea, C.C., Soria, C., Bagus, B. and McCormick, F. (2005) Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. Cancer Cell 8:61-74. [Cover Article]

O'Shea, C.C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Pandey, K., Soria, C., Kunich, J., Shen, Y., Habets, G., Ginzinger, D. and McCormick, F. (2004) Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell 6:611-623.  

 

 

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