Salk Institute

Karlseder Lab - Telomeres

Publications

Karlseder, J., Zeillinger, R., Schneeberger, C., Czerwenka, K., Speiser, P., Kubista, E., Birnbaum, D., Gaudray, P. and Theillet, C. (1994) Patterns of DNA amplification at band q13 of chromosome 11 in human breast cancer. Genes Chromosomes Cancer 9:42-48.

Karlseder, J., Rotheneder, H. and Wintersberger, E. (1996) Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol 16:1659-1667.

Karlseder, J., Wissing, D., Holzer, G., Orel, L., Sliutz, G., Auer, H., Jaattela, M. and Simon, M.M. (1996) HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest. Biochem Biophys Res Commun 220:153-159.

Sliutz, G., Karlseder, J., Tempfer, C., Orel, L., Holzer, G. and Simon, M.M. (1996) Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy. Br J Cancer 74:172-177.

Sutterluety, H., Bartl, S., Karlseder, J., Wintersberger, E. and Seiser, C. (1996) Carboxy-terminal residues of mouse thymidine kinase are essential for rapid degradation in quiescent cells. J Mol Biol 259:383-392.

Orel, L., Simon, M.M., Karlseder, J., Bhardwaj, R., Trautinger, F., Schwarz, T. and Luger, T.A. (1997) alpha-Melanocyte stimulating hormone downregulates differentiation- driven heat shock protein 70 expression in keratinocytes. J Invest Dermatol 108:401-405.

Wolschek, M.F., Narendja, F., Karlseder, J., Kubicek, C.P., Scazzocchio, C. and Strauss, J. (1998) In situ detection of protein-DNA interactions in filamentous fungi by in vivo footprinting. Nucleic Acids Res 26:3862-3864.

Karlseder, J., Broccoli, D., Dai, Y., Hardy, S. and de Lange, T. (1999) p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283:1321-1325.

Karlseder, J., Smogorzewska, A. and de Lange, T. (2002) Senescence induced by altered telomere state, not telomere loss. Science 295:2446-2449.

Smogorzewska, A., Karlseder, J., Holtgreve-Grez, H., Jauch, A. and de Lange, T. (2002) DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr Biol 12:1635-1644.

Karlseder, J. (2003) Telomere repeat binding factors: keeping the ends in check. Cancer Lett 194, 189-197.

Karlseder, J., Kachatrian, L., Takai, H., Mercer, K., Hingorani, S., Jacks, T. and de Lange, T. (2003) Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol 23:6533-6541.

Crabbe, L., Verdun, R.E., Haggblom, C.I. and Karlseder, J. (2004) Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306:1951-1953.

Karlseder, J., Hoke, K., Mirzoeva, O.K., Bakkenist, C., Kastan, M.B., Petrini, J.H. and de Lange, T. (2004) The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol 2:e240.

Crabbe, L. and Karlseder, J. (2005) In the end, it's all structure. Curr Mol Med 5:135-143.

Raices, M., Maruyama, H., Dillin, A. and Karlseder, J. (2005) Uncoupling of longevity and telomere length in C. elegans. PLoS Genet 1:e30.

Verdun, R.E., Crabbe, L., Haggblom, C. and Karlseder, J. (2005) Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol Cell 20:551-561.

Karlseder, J. (2006) Telomeric proteins: clearing the way for the replication fork. Nat Struct Mol Biol 13:386-387.

Verdun, R.E. and Karlseder, J. (2006) The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell 127:709-720.

Crabbe, L., Jauch, A., Naeger, C.M., Holtgreve-Grez, H. and Karlseder, J. (2007) Telomere dysfunction as a cause of genomic instability in Werner syndrome. Proc Natl Acad Sci USA 104:2205-2210.

Karlseder, J. and Cooper, J.P. (2007) Of wombats and whales: telomere tales in Madrid. Conference on telomeres and telomerase. EMBO Rep 8:542-546.

Verdun, R.E. and Karlseder, J. (2007) Replication and protection of telomeres. Nature 447:924-931.

Raices, M., Verdun, R., Compton, S., Haggblom, C., Griffith, J., Dillin, A. and Karlseder, J. (2008) C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. Cell 132:745-757.

Begemann, S., Galimi, F. and Karlseder, J. (2009) Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas. Aging 1:122-130.

Karlseder, J. (2009) Chromosome end protection becomes even more complex. Nat Struct Mol Biol 16: 1205-1206.

Oganesian, L. and Karlseder, J. (2009) Telomeric armor: the layers of end protection. J Cell Sci 122:4013-4025.

Sfeir, A., Kosiyatrakul, S.T., Hockemeyer, D., MacRae, S.L., Karlseder, J., Schildkraut, C.L. and de Lange, T. (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell 138:90-103.

O'Sullivan, R.J. and Karlseder, J. (2010) Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol 11:171-181.

O’Sullivan, R.J., Kubicek, S., Schreiber, S.L. and Karlseder, J. (2010) Reduced histone biosynthesis and chromatin changes aging arising from a damage signal at telomeres. Nat Struct Mol Biol. 17:1218-1225.

Crabbe, L. and Karlseder, J. (2010) Mammalian Rap1 widens its impact. Nat Cell Biol 12:733-735.

Corpet, A., De Koning, L., Toedling, J., Savignoni, A., Berger, F., Lemaitre, C., O’Sullivan, R.J., Karlseder, J., Barrilot, E., Asselain, B., Sastre-Garau, X. and Almouzni, G. (2011) Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. EMBO J 30:480-493.

Lackner, D., Durocher, D. and Karlseder, J. (2011) A siRNA-based screen for genes involved in chromosome end protection. PLoSONE 6:e21407.

Flynn, R.L., Centore, R.C., O’Sullivan, R.J., Rai, R., Tse, A., Songyang, Z., Chang, S., Karlseder, J. and Zou, L. (2011) TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch. Nature 471:532-536.

Oganesian, L. and Karlseder, J. (2011) Mammalian 5' C-rich telomeric overhangs are a mark of recombination-dependent telomere maintenance. Mol Cell 42:224-236.

Orazio, N.I., Naeger, C.M., Karlseder, J. and Weitzman, M.D. (2011) The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. J. Virol 85:1887-1892.

Lackner, D.H., Raices, M., Maruyama, H., Haggblom, C. and Karlseder, J. (2012) Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans. EMBO J 31:2024-33.

Hayashi, M.T., Cesare, A.J., Fitzpatrick, J.A.J., Lazzerini-Denchi, E. and Karlseder, J. (2012) A Telomere Dependent DNA Damage Checkpoint Induced by Prolonged Mitotic Arrest. Nat Struct Mol Biol 19:387-94.

Barefield, C. and Karlseder, J. (2012) The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures. Nucleic Acids Res 40:7358-7367.

Cesare, A.J. and Karlseder, J. (2012) A three-state model of telomere control over human proliferative boundaries. Curr Opin Cell Biol. 24:731-738.

Crabbe, L., Cesare, A.J., Kasuboski, J.M., Fitzpatrick, J.A. and Karlseder, J. (2012) Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. Cell Rep. 2:1521-1529.

O’Sullivan, R. and Karlseder, J. (2012) The great unravelling: chromatin as a modulator of the aging process. Trends Biochem Sci. 37:466-476.

Cesare, A.J., Hayashi, M.T., Crabbe, L. and Karlseder, J. (2013) The telomere deprotection response is functionally distinct from the genomic DNA damage response. Mol Cell. 51:141-155.

Hayashi, M.T. and Karlseder, J. (2013) DNA damage associated with mitosis and cytokinesis failure. Oncogene. 32:4593-4601.

Lackner, D.H. and Karlseder, J. (2013) C. elegans survivors without telomerase. Worm 2:e21073.

Oganesian, L. and Karlseder, J (2013) 5’ C-rich telomeric overhangs are an outcome of rapid telomere truncation events. DNA Repair. 12:238-245.

Lackner, D.H., Hayashi, M.T., Cesare, A.J. and Karlseder, J. (2014) A genomics approach identifies senescence-specific gene expression regulation. Aging Cell. May 23rd Epub ahead of print.

O’Sullivan, R.J., Arnoult, N., Lackner, D.H., Oganesian, L., Haggblom, C., Corpet, A., Almounzi, G. and Karlseder, J. (2014) Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol 21:167-174.

 

 

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