Salk Institute

Karlseder Lab

People

Karlseder Lab

Jan Karleder

Jan Karleder
Professor
karlseder@salk.edu
[CV]

Jan Karlseder received his Ph.D. from the Institute for Molecular Biology in Austria and completed postdocs at both the Center for Applied Genetics (Austria) and Rockefeller University. He is currently a Professor in the Molecular and Cell Biology Laboratory at the Salk Institute for Biological Studies and holder of The Donald and Darlene Shiley Chair.

Nausica Arnoult, Ph.D. Nausica Arnoult
Research Associate
narnoult@salk.edu
Nausica carried out her graduate studies at the Institut Curie, Paris, in Arturo Londono’s lab, where she studied telomere replication. She then moved to Belgium and worked on TERRA and telomere chromatin, at the de Duve Institute, Brussels, in the lab of Anabelle Deccotignies. After an overdose of rain, waffles, sour ale and the finest chocolate, Nausica moved to California and joined the Karlseder lab in July 2012. She is currently working on the characterization of telomeres in C. elegans.

Anthony Cesare

Anthony Cesare
Research Associate
acesare@salk.edu

Tony earned his bachelor degree from Willamette University in Salem, Oregon. He then joined Jack Griffith’s laboratory in the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center. His Ph. D. research in the Griffith lab focused on macromolecular telomere structure in humans, yeast and plants. Tony subsequently moved to Sydney, Australia and completed a post-doctoral fellowship with Roger Reddel in the Cancer Research Unit at the Children’s Medical Research Institute. His research in the Reddel lab focused on the molecular mechanisms underlying spontaneous telomere deprotection in human primary, cancer and immortalized cells. Tony joined the Karlseder lab in August 2009 and is currently focusing on the molecular mechanisms of chromosome end protection in human cells and how telomere deprotection regulates cell cycle arrest.

Candy Haggblom

Candy Haggblom
Lab Manager
haggblom@ucsd.edu

I started with the first class of undergraduates at UCSD in 1964, got hooked on molecular biology in my junior year and have enjoyed doing research ever since. I came to the Salk in 1970 where I learned the basics of tissue culture from Marguerite Vogt and worked with her for 30 years. During that time I helped to develop a working telomerase assay for primary cells and enjoyed reading all the newest telomere papers. So, it seemed like the perfect fit to go to work with Jan Karlseder and to continue with all the exciting telomere research. When I am not involved in solving all the usual lab manager problems you can find me at home in my garden.

Makoto Hayashi

Makoto Hayashi
Research Associate
mhayashi@salk.edu

Makoto completed most of his education, laboratory training, and research experience under the supervision of Professor Hisao Masukata, in the Department of Biology at Osaka University. During his graduate years, he worked on the mechanisms of regulation of DNA replication using fission yeast as a model. He was especially interested in how the chromatin context influences DNA replication origins, which are the regions where DNA synthesis initiates.

Makoto joined the Karlseder lab in April 2009, and his current interest is in how mitotic arrest causes telomere deprotection in normal and immortal cells.

Christine Ichim Christine Ichim
Research Associate
cichim@salk.edu
Coming soon.

Daniel Lackner

Daniel Lackner
Research Associate
dlackner@salk.edu

Daniel did his undergraduate studies in Biology at the University of Vienna. He then moved to the UK to do a Ph.D. at the Wellcome Trust Sanger Institute in the lab of Juerg Baehler, where he used functional genomics approaches to study post-transcriptional gene expression regulation in fission yeast. Daniel joined the Karlseder lab in June 2008 and is at the moment trying to set up a screen to identify novel proteins involved in the regulation of chromosome-end protection.

Roddy O’Sullivan

Roddy O’Sullivan
Research Associate
osullivan@salk.edu

The youngest of the mighty O'Sullivan clan of Inchigeela, Co. Cork, Ireland. I did my undergraduate in Human Genetics at Trinity College Dublin before moving to Vienna, Austria for Ph.D studies at the IMP (Institute for Molecular Pathology) in the lab of Thomas Jenuwein. There I worked on chromatin dynamics, histone modification and epigenetics. Moved to the Karlseder lab in 2007 and have been studying chromatin structure of human telomeres and chromatin modification during replicative senescence. I've gotten so accustomed to the lovely San Diego weather that I will no longer spend time in sub 20 degree celcius climates!

Robert Radford

Robert Radford
Research Associate
rradford@salk.edu

Rob earned his B.Sc. in Pharmacology from University College Dublin with 1st class honors. Continuing with his postgraduate education at the Conway Institute, U.C.D. as part of the Renal Disease Research Group, Rob’s research focused on the development ofin vitro assays and predictive models to detect chemical carcinogenesis in the kidney. This work was carried out as part of the carcinoGENOMICS project. Rob was also particularly interested in the role that the primary cilium plays in chemical carcinogenesis.

Rob joined the Karlseder lab in February of 2012 and is currently interested in developing novel ways to visualize telomere structure.

Teresa Rivera

Teresa Rivera Garcia
Research Associate
trivera@salk.edu

Teresa obtained her PhD in Molecular Biology at the Spanish National Cancer Centre (CNIO) in Madrid, where she studied the regulatory mechanisms that ensure efficient chromosome segregation in Xenopus, such as centromeric identity maintenance, cohesion and spindle assembly. She joined the Karlseder laboratory in February 2011, where she has been investigating the dynamic regulation of telomeric chromatin in stem cells.

Pablo and Yuma Karlseder

Yuma and Pablo

 

Karlseder Lab Alumni

Laure Crabbe
Research Associate

Liana Goodwin
Scientist, Becton Dickinson

 

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