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Back to Basics: Spicing up Alzheimer's drug discovery Marguerite Prior

Marguerite Prior

Marguerite Prior

Salk supporters gathered on October 2 for the latest Back to Basics lecture. Titled "Spicing up Alzheimer's Drug Discovery," it featured Marguerite Prior, a research associate in the Cellular Neurobiology Laboratory of David Schubert.

In her talk, Prior described how the cognitive decline that characterizes Alzheimer's disease results from the progressive loss of nerve cells in areas of the brain and how Schubert's lab has developed a novel drug discovery scheme that uses living neurons grown in laboratory dishes to test new synthetic compounds for effectiveness at protecting brain cells.

Using this strategy, Schubert's team has identified a potent compound, J147, that shows strong therapeutic potential for Alzheimer's by slowing the disease's progression and rapidly improving memory.

The audience was riveted throughout Prior's presentation, and an animated question and answer session followed.