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From feast to famine: A metabolic switch that may help diabetes treatment http://www.salk.edu/news/pressrelease_details.php?press_id=557
The Salk researchers discovered that mice lacking a protein known as fibroblast growth factor 1 (FGF1) were unable to store and use fat normally.
When these mice were switched from a high-fat diet to a normal diet, they developed uneven lumps of fat (seen in white in the above image) in their body tissues, suggesting that their fat metabolism mechanisms had gone awry.
Image: Courtesy of Jae Myoung Suh, research associate, Gene Expression Laboratory
Ronald M. Evans, Professor, Gene Expression Laboratory
Ron Evans, Professor Gene Expression Laboratory, Michael Downes, Senior Staff Scientist and Jae Myoung Suh, Postdoctoral Research Associate.
Images: Courtesy of the Salk Institute for Biological Studies