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Discovery of brain's natural resistance to drugs may offer clues to treating addiction

The left image shows GABA inhibitory neurons (labeled green) in the brain's reward pathway.

The right panel shows electrical activity of GABA inhibitory neuron in a Saline-injected or methamphetamine (METH)-injected mouse.

Activation of the GABA type B receptor normally silences electrical activity, but has no effect in a mouse 24 hours after a single injection of methamphetamine Image: Courtesy of Kelly Tan and Claire Padgett, Salk Institute for Biological Studies

Michaelanne Munoz, UCSD graduate student and Paul Slesinger, Associate Professor, Clayton Foundation Laboratories for Peptide Biology. Image: Courtesy of the Salk Institute for Biological Studies