Salk Institute

Technologies Available for Licensing

Inventors: Ronald Mark Evans, Michael B. McKeown, Anthony Eugene Oro, William A. Segraves, Tso-Pang Yao
Potential Uses: Gene Expression

Novel combinations of various members of the steroid/thyroid superfamily of receptor proteins

In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.

Salk No: S95010
Patent Status: U.S. Patent No. 6,281,330 issued August 28, 2001
Publications:
License Terms: Exclusive or Nonexclusive licenses available
Contact: Michelle Booden, Ph.D., Director of Licensing, 858.453.4100 x1612, mbooden@salk.edu

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