Salk Institute

Technologies Available for Licensing

Inventors: Ronald Mark Evans, Michael B. McKeown, Anthony Eugene Oro, William A. Segraves, Tso-Pang Yao
Potential Uses: Drug Discovery and Development

Methods for using combinations of various members of the steroid/thyroid superfamily of receptor proteins to modulate expression of exogenous genes

In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.

Salk No: S95034
Patent Status: U.S. Patent No. 7,119,077 issued October 10, 2006
Publications: No publications to date
License Terms: Exclusive or Nonexclusive license negotiable
Contact: Michelle Booden, Ph.D., Director of Licensing, 858.453.4100 x1612, mbooden@salk.edu

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