Formulations Useful for Modulating Expression of Exogenous Genes in Mammalian Systems, and Products Related Thereto

Inventors: Ronald Mark Evans, Enrique Saez
Potential Uses: Drug Discovery and Development

Methods and products for modulation of the expression of exogenous genes in mammalian systems

In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in a mammalian subject employing modified ecdysone receptors. Also provided are modified ecdysone receptors, as well as homomeric and heterodimeric receptors containing same, nucleic acids encoding invention modified ecdysone receptors, modified hormone response elements, gene transfer vectors, recombinant cells, and transgenic animals containing nucleic acids encoding invention modified ecdysone receptor.