New Tumor Mouse Models Using CRE Inducible Lentiviral Vectors
Inventors: Yasushi Soda, Tomotoshi Marumoto, & Inder Verma
Potential Uses: Use of Cre-loxP-controlled lentiviral vectors to generate a mouse cancer model(s) in a region- and cell type-specific manner in adult mice. Such models can be used for drug development & biological analysis of tumor development.
Cre recombinase-dependent expression of the recombinant oncogene (Flag H-RasV12) expessed with green fluorescent protein (Green Image) in the hippocampus of GFAP-Cre mice.
Patent Status: Published PCT Application WO28109127
U.S. Patent Application published as 2008/0292591
Publications: Nature Medicine 15, 110 - 116 (2008)
Press Release: Salk researchers develop novel glioblastoma mouse model
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