Salk Institute

Technologies Available for Licensing

Corticotropin-Releasing Factor Overproducing Transgenic Mice

Inventors: Wylie Vale, Mary Stenzel-Poore, George Koob, Stephen Heinrichs
Potential Uses: CNS, Drug Discovery and Development
Transgenic mouse useful to screen compounds that modulate corticotropin-releasing factor levels

This invention relates to a transgenic mouse model exhibiting chronic CRF hypersecretion. These animals express high levels of ACTH and corticosterone throughout their life span and develop phenotypic changes consistent with Cushing's disease and anxiety due to excess glucocorticoid production. Consequently, the invention transgenic mice are useful for a variety of applications, e.g., to screen for compounds that can modulate in-vivo CRF levels, and the like.

Salk No: S93011
Patent Status: U.S. Patent No. 6,023,011 issued February 8, 2000
U.S. Patent No. 6,166,287 issued December 20, 2000
Publications: Endocrinology 130: 3378-3386 (1992)
J. Neuroscience 14: 2579-2584 (1994)
License Terms: Nonexclusive license negotiable
Contact: Michelle Booden, Ph.D., Director of Licensing, 858.453.4100 x1612, mbooden@salk.edu

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