Salk Institute

Technologies Available for Licensing

Kainate Receptor Subunit GluR7 Polymorphisms for Diagnosing Predisposition and for Therapy of Mood Disorders

Inventors: Hans Schiffer and Stephen Heinemann
Potential Uses: CNS, Mood Disorders, Diagnostic, Therapeutic, Drug Discovery
The Kainate Receptor Subunit GluR7 Gene is Associated with Mood Disorders

Mood disorders rank among the top ten causes of disability worldwide. Despite intensive research efforts, the specific genes involved in mood disorder pathology remain to be identified. Thus, it would be useful to identify the genes involved in mood disorders so as to improve diagnosis and therapy. The invention includes methods for determining the predisposition of a subject to a mood disorder by determining the presence of a kainate receptor subunit GluR7 allelic genotype or allelic phenotype. The invention also includes a method of treating or preventing a mood disorder and methods for identifying a compound useful for treatment. Transgenic non-human animals that express only a particular human GluR7 allele also are provided as a model of a human mood disorder.

Salk No: S00007
Patent Status: U.S. Patent Number 6,664,055 issued December 16, 2003
Publications: The Journal of Neuroscience 20(24):9025-9033 (December 2000)
License Terms: Exclusive or Nonexclusive licenses available
Contact: Michelle Booden, Ph.D., Director of Licensing, 858.453.4100 x1612,

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