Salk Institute

Technologies Available for Licensing

IsK Knockout Mouse

Inventors: Steve Heinemann
Potential Uses: Molecular Neurobiology, CNS, Drug Discovery and Development
Mouse model for waltzer syndrome exhibiting hyperactivity, head tilt and bobbing

The IsK gene encodes a small protein of 129-130 amino acids that spans the cell membrane only once and gives rise to slowly activating, voltage dependent K+ conductances. The IsK gene is expressed in the kidney, heart and inner ear. Gene targeting techniques were used in mouse embryonic stem cells to produce mice with a null mutation of the IsK gene. A standard replacement vector was created and used to delete the entire coding sequence of the IsK gene. These IsK knockout mice, which express aberrant behavior due to the K+ channel defect, are models for the waltzer syndrome exhibiting hyperactivity, bi-directional circling, head tilt and bobbing.

Salk No: ISK
Patent Status: No Application filed
Publications: Workshop on Inner Ear Biology, August 31 - September 3, 1996, Utrecht, The Netherlands
Nature 384: News and Views (1996)
J. Membr. Biol. 146: 283-291 (1995) and 147: 263-273 (1995)
Neuron 17: 1251-1264 (1996)
License Terms: Nonexclusive license negotiable
Contact: Michelle Booden, Ph.D., Director of Licensing, 858.453.4100 x1612, mbooden@salk.edu

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