Transcription Factor Regulating FGF-2 and Variants Thereof

Inventors: Fred H. Gage and Tetsuya Ueba
Potential Uses: Oncology, Diagnostic, Drug Discovery
Genes which encode polypeptides that are FGF-2 regulators of transcription

This invention is based on the discovery of genes which encode polypeptides that are FGF-2 regulators of transcription (RFT). RFT-A, a negative regulator of transcription and RFT-A' and RFT-B, positive regulators of FGF-2 transcription are provided. The invention also relates to methods for diagnosis of prognosis for a subject having or at risk of having a disorder associated with FGF-2 and for treatment of cell proliferative disorders associated with FGF-2, such as neoplasia, atrocytoma, glioma, glioblastoma, medulloblastoma, colon cancer, lung cancer, renal cancer, leukemia, testicular cancer, breast cancer, prostate cancer, endometrial cancer and neuroblastoma. Screening methods for identifying a compound which affects RFT-A polypeptide or a variant of RFT-A polypeptide and for identifying proteins that bind to RFT-A polypeptide or a variant of RFT-A are also provided.