Salk Institute

Technologies Available for Licensing

Transcription Factor Regulating FGF-2 and Variants Thereof

Inventors: Fred H. Gage and Tetsuya Ueba
Potential Uses: Oncology, Diagnostic, Drug Discovery
Genes which encode polypeptides that are FGF-2 regulators of transcription

This invention is based on the discovery of genes which encode polypeptides that are FGF-2 regulators of transcription (RFT). RFT-A, a negative regulator of transcription and RFT-A' and RFT-B, positive regulators of FGF-2 transcription are provided. The invention also relates to methods for diagnosis of prognosis for a subject having or at risk of having a disorder associated with FGF-2 and for treatment of cell proliferative disorders associated with FGF-2, such as neoplasia, atrocytoma, glioma, glioblastoma, medulloblastoma, colon cancer, lung cancer, renal cancer, leukemia, testicular cancer, breast cancer, prostate cancer, endometrial cancer and neuroblastoma. Screening methods for identifying a compound which affects RFT-A polypeptide or a variant of RFT-A polypeptide and for identifying proteins that bind to RFT-A polypeptide or a variant of RFT-A are also provided.

Salk No: S98015
Patent Status: U.S. Patent No. 6,326,484 issued December 4, 2001
Publications: J Biol Chem 274(15): 10382-7 (April 1999)
License Terms: Exclusive, Partial Exclusive or Nonexclusive license negotiable
Contact: Michelle Booden, Ph.D., Director of Licensing, 858.453.4100 x1612, mbooden@salk.edu

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