Salk Institute

Technologies Available for Licensing

Plant steroid 5 alpha Reductase, DET 2

Inventors: Joanne Chory and Jianming Li
Potential Uses: Plant Biology, Agriculture, Horticulture
Increased plant yield using a novel gene, DET2 involved in brassinolide synthesis.

The invention describes a novel steroid 5alpha-reductase, DET2, which is involved in the synthesis of the plant steroid hormone, brassinolide. Overexpression of DET2 reductase in transgenic plants causes such plants to become significantly larger and more robust than their wild-type counterparts, thus increasing plant growth, crop growth and/or increased biomass. The invention provides for methods to produce a genetically modified plant characterized as having increased yield as compared to a wild-type plants. The method can include transferring a copy of a DET2-encoding polynucleotide operably associated with a promoter to a plant cell to obtain a transformed plant cell and producing a plant from the transformed plant cell. Also provided is a method of contacting a plant with a native DET2 gene operably linked to its native promoter, with a promoter-inducing amount of an agent which induces DET2 gene expression.

Salk No: S96011
Patent Status: U.S. Patent No. 6,352,846 issued March 5, 2002 U.S. Patent No. 6,143,950 issued November 7, 2000
Publications: Science 272(5260):398-401 (April 1996)
S96011PNAS 94(8):3554-9 (April 1997)
Plant Cell 9(11):1951-62 (November 1997)
S96011Plant Physiol 120(3):833-40 (July 1999)
License Terms: Non-exclusive and Exclusive by Field of Use Licenses Negotiable
Contact: Michelle Booden, Ph.D., Director of Licensing, 858.453.4100 x1612,

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