Salk Institute

Technologies Available for Licensing

Receptor Kinase, BIN1

Inventors: Joanne Chory and Jianming Li
Potential Uses: Plant Biology, Agriculture, Horticulture
Genetic modification of plants to increase BIN1 expression results in a variety of useful phenotypes such as increased yield, enhanced disease resistance, and increased biomass

The brassinosteroids are a unique class of biologically active natural products that possess plant steroidal hormone activity. The brassionosteroids can be used as plant protectants from both pesticide and environmental adversity and appear to be useful in insect control. Further, brassionsteroids can regulate some stage of the reproductive cycle of plants, thereby providing means to increase or decrease the reproductive process. They also appear to stimulate root growth. Historically brasinosteriods have not been used in actual agricultural applications due to the expense of producing them and difficulties in purification. The invention describes a novel steroid receptor kinase, Bin1, which is involved in the pathway for synthesis of the plant brassiosteroid, brassinolide. Overexpresiion of Bin1 in transgenic plants provides plants characterized as having enhanced disease resistance, increased plant yield or vegetative biomass and increased seed yield.

Salk No: S97020
Patent Status: U.S. Patent No. 6,765,085 issued July 20, 2004
U.S. Patent No. 6,245,969 issued June 12, 2001
Publications: Li et al., Cell, vol. 90, 929-938,1997
License Terms: Exclusive and Non-Exclusive Licenses Available
Contact: Michelle Booden, Ph.D., Director of Licensing, 858.453.4100 x1612,

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