Technologies Available for Licensing
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Search Technologies | ||
S03008: Boynton
Surface Segmentation from Luminance and Color Differences
A Bayesian model used to automatically segment scenes based on the luminance and color statistics of a particular image set.
S00014: Bushman
Method of Rapidly Identifying Inhibitors of Topoisomerase DNA Religation
High throughput screen for compounds that modulate topoisomerase activity
S97022B: Bushman
Assay for Integration Inhibitors Using Pre-Integration Complexes
A screen for viral integrase inhibitors
S06007: Callaway
Understanding Neural Networks: Identifying Monosynaptic Connections
Technology that enables specific labeling and/or manipulation of neural networks
S04009B: Choe
Compositions and Methods for Producing Recombinant Membrane-Associated Proteins
A 'partner' molecule called Mistic makes widespread production of large quantities of membrane proteins possible for the first time, allowing scientists to determine their atomic structure and design drugs that interfere with disease processes involving crucial proteins such as ion channels and GPCRs.
S08013: Chory
A Zinc Protein That Controls Morning-specific Growth in Plants
Growth in plants is modulated by a complex interplay between internal signals and external cues.
S06016: Chory
Compositions, Cells, and Plants that Include BK11, A Negative Regulator of BRI1-Mediated BR Signaling
The BRI1 gene encodes a receptor serine/threonine kinase. Loss-of-function mutations in BRI1 result in dwarf plants that resemble steroid-deficient plants.
S02023: Chory
Modulation of Flowering Time by the PFT1 Locus
A gene useful in protecting crops from shade-avoidance resulting in increased yields
S01015: Chory
DAS5, a P450 Protein Involved in the Brassinosteroid Biosynthesis Pathway of Plants
Genetic modifications of plants to increase the expression of DAS5 results in a variety of useful phenotypes such as increased fresh weight and increased overall plant size.
S01014: Chory
Genes Involved in Brassinosteroid Hormone Action in Plants
Methods of altering plant phenotypes including plant size by altering the genes encoding the Brassinozole Resistant 1 (BZR1) Polypeptide.
S00015: Chory
Expression of Flavin-Containing Monooxygenases in Plants
A gene to increase plant growth and yield by increasing endogenous auxin levels.
S97020: Chory
Receptor Kinase, BIN1
Genetic modification of plants to increase BIN1 expression results in a variety of useful phenotypes such as increased yield, enhanced disease resistance, and increased biomass
S96011: Chory
Plant steroid 5 alpha Reductase, DET 2
Increased plant yield using a novel gene, DET2 involved in brassinolide synthesis.
S01009: Ecker
Methods and Compositions to Modulate Ethylene Sensitivity
Novel transcription factors affecting ethylene sensitivity in plants
S01008: Ecker
Ethylene Insensitive Plants
Mutants conferring ethylene insensitivity on plants
S01002: Ecker
Genetic Control of Organ Abscission (NEVERSHED)
Mutation in the NEVERSHED family resulting in decreased plant organ abscission. NEV provides opportunities to increase crop yield and to control shedding.
S08001: Emerson
Epigenetic Silencing of Tumor Suppressor Genes
Epigenetic silencing of tumor suppressor genes occurs through loss of CTCF binding and chromatin boundaries
S00004: Emerson
Method of Regulating Transcription in a Cell and Methods of Modulating Gene Expression
Chromatin based technology to define novel and highly specific protein targets for selective gene modulation
S09026: Evans
Adipose-derived Induced Pluripotent Stem Cells
Model system for studying the molecular mechanisms of feeder-free iPS generation and maintenance
S98002: Evans
Formulations Useful for Modulating Expression of Exogenous Genes in Mammalian Systems, and Products Related There
In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in a mammalian subject employing modified ecdysone receptors.
S98001: Evans
Products Useful for Modulating Expression of Exogenous Genes in Mammalian Systems
Modulation of exogenous gene expression in mammalian and other systems using modified ecdysone receptors
S96028: Evans
Use of RAR Antagonists as Modulators of Hormone Mediated Processes
RAR Antagonists are capable of modulating processes mediated by other members of the steroid/thyroid hormone receptor superfamily, including permissive receptors such as PPARs.
S96024A: Evans
Treatment of Disease States which Result from Neoplastic Cell Proliferation Using PPAR-gamma Activators and Compositions Useful Therefor
Administration of PPAR-gamma agonists, optionally in combination with RXR specific agonists, can block neoplastic cell proliferation
S96023A: Evans
Treatment of Liposarcomas Using a Combination of Thiazolidinediones and Retinoid X Receptor Selective Agonists
Compositions useful for the treatment of liposarcomas
S95034: Evans
Methods of Modulating the Expression of Genes Using Ultraspiracle Receptor Inventors
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species.
S95031: Evans
Selective Modulators of PPAR-gamma and Methods for the Use Thereof
Use of PPAR-gamma-selective compounds for the treatment of obesity and diabetes.
S95010: Evans
Multimeric Forms of Members of the Steroid/Thyroid Superfamily of Receptors with the Ultraspiracle Receptor
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species.
S91020: Evans
Bioassays for Identifying Antagonists of Receptors of the Steroid/ Thyroid Superfamily
The present invention relates to bioassays for evaluating compounds as potential antagonists for members of the steroid hormone superfamily of receptor protein(s).
S97047B: Evans
Transgenic Mice Expressing a Human SXR Receptor Polypeptide (Alb-hSXR-Tg and FABP-hSXR-Tg mice available)
S09023: Gage
A New Diagnostic Assay: Measuring Retrotransposition in Man
L1 retrotransposition in human neural progenitor cells
S09001: Gage
Computational Model of Neurogenesis
Role of Neurogenesis in Pattern Separation Neural Networks
S08017: Gage
Pluripotent Stem Cells from Neuronal Cells
Transcriptional analysis of virus-free human induced pluripotent cells
S08014: Gage
Human Cell Assay for Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative adult disease characterized by fatal paralysis in both the brain and spinal cord motor neurons due to motor neuron death.
S04010: Gage
A Molecular Switch Regulating Neurogenesis
A "master switch" that determines whether the genetic program that mediates neural differentiation is repressed or activated
S98035: Gage
Regulation of Tyrosine Hydroxylase Expression
Nurr1 polypeptide upregulates tyrosine hydroxylase activity and promotes expression of DOPA, norepinenephrine and epinephrine.
S98032: Gage
Hormone Receptor Functional Dimers and Methods of Use
S98015: Gage
Transcription Factor Regulating FGF-2 and Variants Thereof
Genes which encode polypeptides that are FGF-2 regulators of transcription
S97001: Gage
Modified Lepidopteran Receptors and Hybrid Multifunctional Proteins for Use in Transcription and Regulation of Transgene Expression
This invention relates to nuclear receptor proteins isolated from the silk moth bombyx mori (bR) which are useful for the regulation of transgene expression.
S96013: Gage
Modular Assembly Retroviral Vectors and Uses Therefor
Gene transfer vectors with the capacity for prolonged or modulated transgene expression
S00007: Heinemann
Kainate Receptor Subunit GluR7 Polymorphisms for Diagnosing Predisposition and for Therapy of Mood Disorders
The Kainate Receptor Subunit GluR7 Gene is Associated with Mood Disorders
S97031: Hope
Stimulation of Transgene Expression by RNA Export Elements
Enhance transgene expression by promoting correct processing and transport of RNA from the cell nucleus to the cytoplasm.
S09011: Izpisua Belmonte
Increased Reprogramming for Generating Pluripotent Stem Cells
Induced pluripotent stem (iPS) cell generation using two factors and p53 inactivation
S09007: Izpisua Belmonte
A Step Toward Safe Derivation of Clinically Relevant Human Induced Pluripotent Stem Cells
A single plasmid construct that expresses four transcription factors from one polycistronic unit
S08024: Izpisua Belmonte
Production of Induced Pluripotent Stem Cells: Generation from a Single Hair
Induced Pluripotent Stem Cells and Methods of Use
S97041: Jones
Cyclin T, A New HIV Target
Materials and methods useful for identifying compounds that prevent binding of Cyclin T to HIV Tat, thus disrupting HIV's infection cycle.
S96006: Lamb
Method of Increasing Growth and Yield in Plants (Cyclin)
CYC1 Cyclin gene, which promotes increased root mass, shoot and fruit growth
S02016A: Landau
Alpha-Complementation Viral Fusion Assay
A rapid and quantitative assay to detect HIV and other viral mediated fusion to screen for inhibitors
S05002: Lee
Nerve Regeneration: Compositions and Methods
Methods and compositions for promoting nerve growth and/or regeneration, including what is believed to be the first demonstration of locomotor functional recovery following a complete spinal cord transection.
S08022: Lemke
A Novel Animal Model for Studying Anticoagulants: Protein S Deficient Mice
Protein S (ProS) is a blood anticoagulant, and ProS deficiencies are associated with venous thrombosis, stroke, and autoimmunity.
S03003: Makeig
Complex Spectral Domain ICA, a New Dimension in Biosignal Analysis
An improved complex signal separation method capable of opening a new window into the dynamics of EEG activity.
S06002: Montminy
Increasing Fat Metabolism: Identification of a New Pathway in Adipose Tissue
During fasting, adipose lipid stores are mobilized to provide fatty acids for use as a metabolic energy source.
S04005: Montminy
Modulating Gluconeogenesis: Indirect Phosphorylation of TORC2 from Insulin.
Glucose levels are maintained within a narrow range in humans through counter-regulatory effects of pancreatic hormones on hepatic gluconeogenesis, including insulin.
S02011: Montminy
Protein Kinase B/AKT Modulators and Methods of Use Thereof
A protein, TRB3, found to be overexrpessed in response to diabetes and fasting is an attractive drug target in the treatment of type II diabetes.
S06006: Noel
Metabolic engineering of lipid metabolism by improving fatty acid binding and transport
Metabolic pathway engineering of lipids in plants; protein crystallography and design.
S04008B: Noel
Novel Aromatic Prenyltransferases, Nucleic Acids Encoding Same and Uses Therefor
Enzyme that transfers a prenyl group is found to be unexpectedly promiscuous
S00010B: Noel
Modulation of Mevalonate-Independent Isoprenoid Biosynthetic Pathway
Templates for the design of novel antibacterial and antiparasitic drugs
S08010: OLeary
Controlling Axon Growth and Mapping in the Visual System
Axonal connections in the mature nervous system are extraordinarily precise.
S96032: Rivier
Corticotropin-Releasing Factor (CRF) Antagonists
Drugs to activate CRF receptors based on peptide antagonists
S96027: Rivier
Gonadotropin Releasing Hormone (GnRH) Analogs
Potent GnRH antagonists with significantly increased duration of action, useful for applications including fertility regulation, endometriosis, hormone-dependent tumors, and precocious puberty.
S05006: Sefton
Methods of Inhibiting Poxvirus Growth
Targets for the development of anti-smallpox drugs
S07015: Sejnowski
Miniature Acousto-Optic 3D Scanning Microscope
Miniature, lightweight wearable multiphoton microscope with microsecond 3D random access capable of deep tissue imaging
S05003: Sejnowski
Multi-Photon Objective
Hybrid reflecting micoscope objectives for deep-tissue functional two-photon imaging
S09022: Shaw
Imaging and Treatment of Intestinal Cancer: Peutz-Jeghers Syndrome
Gastrointestinal Disease or Disorder Imaging and Treatment
S06017: Slesinger
Kir Channel Modulators
Methods and materials for modulating Kir channel activity and identification of related compounds.
S08023: Thomas
Non-Mammalian Animal Models with Glioma for Cancer Discovery
Gliomas, neoplasms of glial cells and their precursors, are the most common malignant tumors of the central nervous system (CNS).
S96012: Vale
Urocortin
A native mammalian peptide with potent hypotensive activity used as a therapeutic or target
S93011: Vale
Corticotropin-Releasing Factor Overproducing Transgenic Mice
Transgenic mouse useful to screen compounds that modulate corticotropin-releasing factor levels
S08005: Verma
IKK2: A Central Player in Allergic Reactions
Methods of identifying IKK2 activators or inhibitors for regulation of mast cell degranulation
S07006B: Verma
New Tumor Mouse Models Using Lentiviral Vectors
Cre recombinase-dependent expression of the recombinant oncogene (Flag H-RasV12) expessed with green fluorescent protein (Green Image) in the hippocampus of GFAP-Cre mice.
S02015B: Verma
Compositions and Methods for Tissue Specific Targeting
Lentiviral targeting vectors capable of being targeted to any desired cell or tissue that contains an identifying cell surface marker.
S97022A: Verma
Retroviral Packaging Cell Line
Produces high titers of pseudotyped retroviral particles capable of transducing nondividing cells.
pCL: Verma
pCL Vector System: Rapid Production of Helper-Free, High-Titer, Recombinant Retroviruses
Maximize recombinant-retrovirus titers in a simple, robust, and flexible experimental system.
S97025: Wahl
Site-Specific Recombination in Eukaryotes and Constructs Useful Therefor
A fusion of the protamine 1 gene promoter with the Cre recombinase gene for efficient manipulation of chromosomal sequences in mammalian systems
S95048: Wahl
FLP-Mediated Gene Modification in Mammalian Cells, and Compositions and Cells Useful Therefor
Rapid and precise site-specific recombination in mammalian cells
S09008: Wang
Increasing Unnatural Amino Acid Incorporation 5-Fold in Mammalian Cells
Improved orthogonal tRNA-synthetase recognition for efficient unnatural amino acid incorporation and application in mammalian cells
S07007: Wang
Methods of Genetically Encoding Unnatural Amino Acids in Eukaryotic Cells Using Orthogonal TRNA/Synthetase Pairs
Genetic encoding of novel amino acids in mammalian cells, high-yield production of unnatural amino acids and novel proteins.
S97038: Weigel
Flowering Locus T (FT) and Genetically Modified Plants having Modulated Flower Development
A novel gene that modulates the flowering time of plants.
S94047: Weigel
Genetically Modified Plants Having Modulated Flower Development
Inducing early flowering or sterility in plants
S07014: Young
Non-Nucleoside Reverse Transcriptase Inhibitors
Novel NNRTIs, compounds and pharmaceutical compositions for reducing HIV infection and replication.
S07001: Young
A Novel Antitoxin and Vaccine Platform Based on Nodavirus VLPS
A novel, chimeric virus-like particle (VLP) capable of multivalent display of PA shows significant advantages over existing monovalent PA immunogens for anthrax toxin. Studies indicate VLP-PA complex may eliminate the need for lengthy immunization schedules by providing immunity after a single injection, and has potential to generate effective vaccines against other pathogens, including combination vaccines immunizing against multiple toxins.
