Increasing Fat Metabolism: Identification of a New Pathway in Adipose Tissue
During fasting, adipose lipid stores are mobilized to provide fatty acids for use as a metabolic energy source.
Modulating Gluconeogenesis: Indirect Phosphorylation of TORC2 from Insulin.
Glucose levels are maintained within a narrow range in humans through counter-regulatory effects of pancreatic hormones on hepatic gluconeogenesis, including insulin.
Protein Kinase B/AKT Modulators and Methods of Use Thereof
A protein, TRB3, found to be overexrpessed in response to diabetes and fasting is an attractive drug target in the treatment of type II diabetes.
TORC1 (Crtc1) knock-out mice