Salk Institute

Technologies Available for Licensing


T09010: Evans

VgEcR/RXR expressing mice


S09026: Evans

Adipose-derived Induced Pluripotent Stem Cells
Model system for studying the molecular mechanisms of feeder-free iPS generation and maintenance


T09009: Evans

TLX null; b-gal knock-in mice


S98002: Evans

Formulations Useful for Modulating Expression of Exogenous Genes in Mammalian Systems, and Products Related There
In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in a mammalian subject employing modified ecdysone receptors.


S98001: Evans

Products Useful for Modulating Expression of Exogenous Genes in Mammalian Systems
Modulation of exogenous gene expression in mammalian and other systems using modified ecdysone receptors


T09008: Evans

PPARd-null ES cells


T09007: Evans

PPARd floxed mice


S96028: Evans

Use of RAR Antagonists as Modulators of Hormone Mediated Processes
RAR Antagonists are capable of modulating processes mediated by other members of the steroid/thyroid hormone receptor superfamily, including permissive receptors such as PPARs.


T09005: Evans


S96024A: Evans

Treatment of Disease States which Result from Neoplastic Cell Proliferation Using PPAR-gamma Activators and Compositions Useful Therefor
Administration of PPAR-gamma agonists, optionally in combination with RXR specific agonists, can block neoplastic cell proliferation


S96023A: Evans

Treatment of Liposarcomas Using a Combination of Thiazolidinediones and Retinoid X Receptor Selective Agonists
Compositions useful for the treatment of liposarcomas


T09004: Evans

PPARg-null ES cells


T09003: Evans

PPARg Transgenic Mice (PPARg-VP16 Tg)


S95034: Evans

Methods of Modulating the Expression of Genes Using Ultraspiracle Receptor Inventors
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species.


S95031: Evans

Selective Modulators of PPAR-gamma and Methods for the Use Thereof
Use of PPAR-gamma-selective compounds for the treatment of obesity and diabetes.


T09002: Evans

PPARg floxed mice


T09001: Evans

PPARg null; b-gal knock-in mice


S95010: Evans

Multimeric Forms of Members of the Steroid/Thyroid Superfamily of Receptors with the Ultraspiracle Receptor
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species.


T09000: Evans

mCAR-VP16 Tg mice


S91020: Evans

Bioassays for Identifying Antagonists of Receptors of the Steroid/ Thyroid Superfamily
The present invention relates to bioassays for evaluating compounds as potential antagonists for members of the steroid hormone superfamily of receptor protein(s).


S97047B: Evans

Transgenic Mice Expressing a Human SXR Receptor Polypeptide (Alb-hSXR-Tg and FABP-hSXR-Tg mice available)


T09006: Evans

PPARd null; b-gal knock-in mice


S00021: Evans

Novel Histone Deacetylase and Uses Therefor
The histone deacetylases are involved in cell-cycle regulation and differentiation and have been implicated in repression of gene expression.


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