Salk Institute
Scientists and Research
Wolfgang  Fischer

Wolfgang Fischer

Senior Staff Scientist
Clayton Foundation Laboratories for Peptide Biology

Research in Dr. Fischer’s laboratory is conducted in two major areas, the functional analysis of growth factor signaling and the characterization of proteins by mass spectrometry. The investigation of growth factors focuses on activin, a member of the TGF- b superfamily of growth and differentiation factors. The aim of the investigation is a detailed understanding of the events that lead to specificity of receptor binding and signal transduction.

In addition to his research projects, Dr. Fischer directs the Vincent J. Coates Foundation Center for Mass Spectrometry at the Salk Institute. The Center employs state-of-the-art mass spectrometry to identify proteins involved in biological processes. Besides protein identification, the characterization of posttranslational modifications is a major research focus.

Education

  • Ph.D., Biochemistry, RWTH Aachen, Germany
  • Postdoctoral Fellow, The Salk Institute, La Jolla

Awards and Honors

  • Ph.D. Fellowship, German National Merit Foundation
  • Borchers Medal, RWTH Aachen
  • Postdoctoral Fellowship, Boehringer Ingelheim Foundation

Selected Publications

  • Witherden DA, Watanabe M, Garijo O, Rieder SE, Sarkisyan G, Cronin SJ, Verdino P, Wilson IA, Kumanogoh A, Kikutani H, Teyton L, Fischer WH, Havran WL 2012 The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal gammadelta T cell function. Immunity 37:314-325
  • Wang Y, Li G, Goode J, Paz JC, Ouyang K, Screaton R, Fischer WH, Chen J, Tabas I, Montminy M 2012 Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature 485:128-132
  • Wang B, Moya N, Niessen S, Hoover H, Mihaylova MM, Shaw RJ, Yates JR, 3rd, Fischer WH, Thomas JB, Montminy M 2011 A hormone-dependent module regulating energy balance. Cell 145:596-606
  • Chiron S, Wei Z, Chen Y, Zhang K, Wen G, Fischer WH, Mahata SK, O'Connor DT 2011 Proteomic analysis yields an unexpected trans-acting point in control of the human sympathochromaffin phenotype. Circ Cardiovasc Genet 4:437-445
  • Muenster U, Korupolu R, Rastogi R, Read J, Fischer WH 2011 Antagonism of activin by activin chimeras. Vitam Horm 85:105-128
  • Witherden DA, Verdino P, Rieder SE, Garijo O, Mills RE, Teyton L, Fischer WH, Wilson IA, Havran WL 2010 The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science 329:1205-1210
  • Wang Y, Vera L, Fischer WH, Montminy M 2009 The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460:534-537
  • Herrera F, Chen Q, Fischer WH, Maher P, Schubert DR 2009 Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome. Cell Death Differ 16:910-920
  • Schubert D, Herrera F, Cumming R, Read J, Low W, Maher P, Fischer WH 2009 Neural cells secrete a unique repertoire of proteins. J Neurochem 109:427-435
  • Blount AL, Schmidt K, Justice NJ, Vale WW, Fischer WH, Bilezikjian LM 2009 FoxL2 and Smad3 coordinately regulate follistatin gene transcription. J Biol Chem 284:7631-7645
  • Korupolu RV, Muenster U, Read JD, Vale W, Fischer WH 2008 Activin A/bone morphogenetic protein (BMP) chimeras exhibit BMP-like activity and antagonize activin and myostatin. J Biol Chem 283:3782-3790
  • Shani G, Fischer WH, Justice NJ, Kelber JA, Vale W, Gray PC 2008 GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol 28:666-677

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